生态基因毒理学：个人反思。

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation Research-Reviews in Mutation Research Pub Date : 2025-01-01 DOI:10.1016/j.mrrev.2025.108535

Awadhesh N. Jha

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引用次数: 0

摘要

这篇反思性的评论提供了一个个人的发展观点，在过去的30年里，在相对较新的多学科领域“生态基因毒理学”，也被称为“遗传生态毒理学”。它旨在概述与学科历史发展相关的学科领域范围，对已取得的成就进行批判性分类，并考虑到现有信息。它还认识到现有资料的局限性和在这一具有挑战性的领域遇到的困难。在适当的情况下，本文对人类遗传毒理学和辐射生物学的进展进行了比较。本文批判性地涵盖了在该领域使用的流行和新兴工具的应用，例如组学，体外方法，建模方法和人工智能（AI）。它还确定了潜在的发展领域，并试图赞扬在这一与人类和环境健康有关的令人兴奋和具有挑战性的主题中作出的一些重要的个人贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Eco-genotoxicology: A personal reflection

This reflective commentary provides a personal viewpoint of developments, over the last 3 decades, in the relatively new, multidisciplinary field of ‘eco-genotoxicology,’ also called ‘genetic ecotoxicology’. It aims to outline the scope of the subject area in relation to the historical development of the discipline, critically categorising accomplishments made, taking into account the available information. It also recognises limitations of the existing information and difficulties encountered in this challenging field. Where appropriate, the article makes comparisons to the advances made in human genetic toxicology and radiation biology. The article critically covers the applications of prevailing and emerging tools being used in the field, such as omics, in vitro methodologies, modelling approaches, and artificial intelligence (AI). It also identifies potential areas of development and attempts to credit some of the important personal contributions made in this exciting and challenging subject in relation to human and environmental health.

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.