理解性少数青少年的自杀:对社会线索的神经反应作为调节影响。

IF 2.5 3区 医学 Q2 BEHAVIORAL SCIENCES
T H Stanley Seah, Kristen L Eckstrand, Tina Gupta, Michael P Marshal, Erika E Forbes
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引用次数: 0

摘要

性少数青年(SMY)经历了更高的自杀风险,部分原因是围绕性取向身份的耻辱。神经生物学特征可以影响对社会线索的反应(例如,感知到的喜欢或拒绝)和自杀风险。这些影响在青春期会加剧,因为青春期是对社会环境高度敏感的发育时期。在这项针对不同精神风险青少年的横断面研究中,我们研究了对社会线索的神经反应是否会缓和性少数身份与自杀意念(SI)之间的联系,以及性取向受害经历是否会进一步影响这些影响。青年75名(14-22岁);52%的男同性恋者,48%的异性恋者)报告了抑郁,SI和受害,并完成了功能性磁共振成像任务,包括在奖励和模糊的环境中观看不熟悉的面部刺激和接受社会线索。兴趣区域分析检查了神经社会区域中与任务相关的神经反应。采用线性回归进行适度分析。性少数青年报告更严重的抑郁、受害和性暴力
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding suicide in sexual minority youth: neural reactivity to social cues as a moderating influence.

Sexual minority youth (SMY) experience heightened suicide risk, partly because of stigma surrounding sexual orientation identity. Neurobiological characteristics can influence reactivity to social cues (e.g., perceived liking or rejection) and suicide risk. These effects are exacerbated during adolescence-a developmental period of heightened sensitivity to social contexts. In this cross-sectional study of youth at varying psychiatric risk, we examined whether neural reactivity to social cues moderated the link between sexual minority status and suicidal ideation (SI) and whether sexual orientation victimization experiences further influenced these effects. Seventy-five youth (aged 14-22 years; 52% SMY, 48% heterosexual) reported depression, SI, and victimization, and completed a functional magnetic resonance imaging task involving viewing of unfamiliar face stimuli and receipt of social cues in rewarding and ambiguous contexts. Regions-of-interest analyses examined task-related neural reactivity in neural social regions. Moderation analyses were conducted using linear regressions. Sexual minority youth reported more severe depression, victimization, and SI (p < .05). Left temporoparietal junction (TPJ) activation to social cues, regardless of the degree of valence and certainty, moderated the link between sexual minority status and SI, where SMY (vs. non-SMY) with dampened left TPJ activity had higher SI. Exploratory analyses indicated that these associations were not further influenced by victimization. Results indicate enhanced suicide risk in SMY with altered social processing in the TPJ-a key region of neural social systems-across contexts, regardless of victimization history. Findings suggest that individual differences in neural reactivity to social cues are critical for understanding SMY suicide risk and have potentially important clinical implications.

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来源期刊
CiteScore
5.00
自引率
3.40%
发文量
64
审稿时长
6-12 weeks
期刊介绍: Cognitive, Affective, & Behavioral Neuroscience (CABN) offers theoretical, review, and primary research articles on behavior and brain processes in humans. Coverage includes normal function as well as patients with injuries or processes that influence brain function: neurological disorders, including both healthy and disordered aging; and psychiatric disorders such as schizophrenia and depression. CABN is the leading vehicle for strongly psychologically motivated studies of brain–behavior relationships, through the presentation of papers that integrate psychological theory and the conduct and interpretation of the neuroscientific data. The range of topics includes perception, attention, memory, language, problem solving, reasoning, and decision-making; emotional processes, motivation, reward prediction, and affective states; and individual differences in relevant domains, including personality. Cognitive, Affective, & Behavioral Neuroscience is a publication of the Psychonomic Society.
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