症状性外周动脉疾病患者监督运动训练后1年功能表现和生活质量的性别差异

IF 3 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Vascular Medicine Pub Date : 2025-04-30 DOI:10.1177/1358863X251322394

Stefano Lanzi, Anina Pousaz, Luca Calanca, Lucia Mazzolai

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Functional performance (6-minute walking distance [6MWD], the stair-climbing test [SCT], and the short physical performance battery [SPPB]), and HRQoL (physical component summary [PCS] score of the Short Form-36 questionnaire) were assessed before and following SET, as well as at 6 and 12 months after SET completion.Results: Ninety patients (women: n = 30; men: n = 60) with chronic symptomatic PAD (ankle-brachial index 0.78 ± 0.22; mean age 65.4 ± 10.2 years) were included in the study. 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引用次数: 0

摘要

导论：有监督的运动训练（SET）对症状性外周动脉疾病（PAD）患者功能表现和健康相关生活质量（HRQoL）的长期影响研究甚少，尤其是在女性中。这项研究调查了SET后1年女性和男性的这些结果。方法：在这项单臂、前瞻性、非随机研究中，对参加3个月SET计划的有症状的PAD患者进行调查。功能表现（6分钟步行距离[6MWD]、爬楼梯测试[SCT]、短体能测试[SPPB]）、HRQoL（短表36问卷的体能成分总结[PCS]得分）在SET前、SET后、SET完成后6个月和12个月进行评估。结果：90例患者(女性：n = 30；男性：60例)伴有慢性症状性PAD(踝肱指数0.78±0.22；平均年龄（65.4±10.2岁）。6MWD(女：前：387.2±88.6米；后：472.4±57.0 m；12个月：469.9±57.8 m；男：前：431.7±94.0米；后：477.5±88.6 m；12个月：467.2±73.4 m)， SPPB评分(女性：术前：9.6±2.4；后：11.3±1.0；12个月：11.2±0.5；男：前：10.6±1.4；后：11.5±0.9；12个月：11.3±0.8)和SCT(女性：之前：8.6±4.4 s；后：5.6±1.6 s；12个月：5.8±1.2 s；男：前：6.2±2.3秒；后：5.0±1.9 s；12个月：5.3±1.6 s)随时间显著改善（p≤0.001），男女间无显著差异。PCS评分(女性：术前：30.3±8.0；后：38.8±8.4；12个月：35.7±7.4；男：前：32.4±10.5；后：35.7±9.5；12个月：35.4±7.6)，仅女性显著改善（p = 0.020）。结论：SET治疗一年后，PAD患者男女均表现出相似的功能获益，而HRQoL的改善仅在女性中观察到。

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Sex-based difference in functional performance and quality of life 1 year after supervised exercise training in patients with symptomatic peripheral artery disease.

Introduction: The long-term effects of supervised exercise training (SET) on functional performance and health-related quality of life (HRQoL) in symptomatic peripheral artery disease (PAD) are poorly investigated, especially in women. This study investigated these outcomes 1 year after SET in both women and men.

Methods: In this single-arm, prospective, nonrandomized study, patients with symptomatic PAD participating in the 3-month SET program were investigated. Functional performance (6-minute walking distance [6MWD], the stair-climbing test [SCT], and the short physical performance battery [SPPB]), and HRQoL (physical component summary [PCS] score of the Short Form-36 questionnaire) were assessed before and following SET, as well as at 6 and 12 months after SET completion.

Results: Ninety patients (women: n = 30; men: n = 60) with chronic symptomatic PAD (ankle-brachial index 0.78 ± 0.22; mean age 65.4 ± 10.2 years) were included in the study. The 6MWD (women: before: 387.2 ± 88.6 m; after: 472.4 ± 57.0 m; 12 months: 469.9 ± 57.8 m; men: before: 431.7 ± 94.0 m; after: 477.5 ± 88.6 m; 12 months: 467.2 ± 73.4 m), SPPB score (women: before: 9.6 ± 2.4; after: 11.3 ± 1.0; 12 months: 11.2 ± 0.5; men: before: 10.6 ± 1.4; after: 11.5 ± 0.9; 12 months: 11.3 ± 0.8), and SCT (women: before: 8.6 ± 4.4 s; after: 5.6 ± 1.6 s; 12 months: 5.8 ± 1.2 s; men: before: 6.2 ± 2.3 s; after: 5.0 ± 1.9 s; 12 months: 5.3 ± 1.6 s) significantly improved over time (p ≤ 0.001), with no significant differences between women and men. The PCS score (women: before: 30.3 ± 8.0; after: 38.8 ± 8.4; 12 months: 35.7 ± 7.4; men: before: 32.4 ± 10.5; after: 35.7 ± 9.5; 12 months: 35.4 ± 7.6) significantly improved in women only (p = 0.020).

Conclusion: One year after SET, both women and men with PAD exhibit similar functional benefits, whereas HRQoL improvements were observed exclusively in women.

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来源期刊

Vascular Medicine 医学-外周血管病

CiteScore

5.70

自引率

5.70%

发文量

158

审稿时长

>12 weeks

期刊介绍： The premier, ISI-ranked journal of vascular medicine. Integrates the latest research in vascular biology with advancements for the practice of vascular medicine and vascular surgery. It features original research and reviews on vascular biology, epidemiology, diagnosis, medical treatment and interventions for vascular disease. A member of the Committee on Publication Ethics (COPE)