Bethany C Yang, Kathleen M Sanchez, Kim M Moore, Marc L Yang, Naman K Shah
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Maximizing doses from multi-dose vaccine vials using the air bubble trapping technique.
Purpose: Vaccine shortages present significant challenges for public health, necessitating strategies such as fractional dosing and the use of adjuvants to conserve doses. However, reducing vaccine wastage remains essential. One approach is the air bubble trapping technique (ABTT), which involves trapping an air bubble to minimize dead volume loss and maximize the number of doses extracted from multi-dose vials.
Materials and methods: This study compares ABTT with standard methods using 3 syringe types. Healthcare workers prepared 0.1 mL and 0.5 mL saline doses both with and without ABTT.
Results: Results showed that ABTT produced comparable vaccine volumes to conventional techniques but required extra preparation time. ABTT reduced volume by 8.6% for 0.1 mL doses and 2.9% for 0.5 mL doses, with preparation times of 30.63 and 32.95 seconds, compared to 12.53 and 15.11 seconds without ABTT.
Conclusion: ABTT was consistent across different syringe types and levels of user experience, allowing for practical integration into vaccination workflows.
期刊介绍：
Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide
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