Second to Fourth Digit Ratio (2D:4D) and Cognitive Functioning in Bipolar Disorder.

Introduction: Bipolar Disorder(BD) involves complex mood, neuropsychological, immunological, and physiological changes, with cognitive impairments persisting even during remission.Our study aimed to investigate the relationship between the second-to-fourth digit ratio(2D:4D) and cognitive functions in BD patients.

Methods: Our cross-sectional study, which included forty-seven BD patients in remission for at least six months and forty-seven healthy volunteers, was designed to thoroughly understand the relationship between the 2D:4D and cognitive functions in BD.All participants were administered Stroop Test(ST), Wisconsin Card Sorting Test(WCST), and Trail Making Test A and B forms(TMT-A/B). The same researcher measured the 2D:4D ratio using a digital caliper, ensuring consistency and accuracy.

Results: The left 2D:4D ratio was significantly higher in the patient group than healthy controls. Additionally, there was a statistically significant difference in ST, WCST, and TMT-A/B scores between the two groups, with the BD group scoring higher and being more unsuccessful.We also observed a weak negative correlation between the completion time of the TMT A form and the right-hand 2D:4D finger ratios in the BD group.

Conclusion: The findings of our study carry significant implications.They reveal a marked difference in the 2D:4D of patients compared to healthy controls and a decline in the cognitive functions of patients even during remission.