副流感病毒2型诱导的18岁健康男性患者横纹肌溶解:一个病例研究

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Mustafa K Al Nuaimi, Sara Ubosy, Hakeem A Mohammed, Kwabena Ayesu, Mario Madruga, Stephen J Carlan
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引用次数: 0

摘要

横纹肌溶解是一种以骨骼肌组织细胞分解为特征的疾病,导致基本肌肉成分释放到血液中。据报道有多种病因,包括涉及骨骼肌细胞的感染。引起横纹肌溶解的最常见的感染类型之一是源于病毒。临床上,患者通常表现为短暂的潜伏期,包括全身不适,随后出现肌肉酸痛、肌痛,甚至出现疼痛性步态。骨骼肌损伤程度越高,血清肌红蛋白水平越高。当肌红蛋白的水平超过蛋白质结合能力时,该分子可在肾小球滤过过程中沉淀并损害肾脏。病例报告一名18岁的健康男性患者,在经历了5天的全身不适和2天的逐渐衰弱的骨骼肌疼痛和功能障碍,导致无法行走后,被送到急诊室(ED)。他的症状消失了,直到不能走动为止。到达急诊科时,他的肌酸激酶(CK)水平升高至6859 U/L(参考值10-70 U/L),鼻咽呼吸聚合酶链反应小组鉴定为2型副流感病毒。给予对乙酰氨基酚、甲氨基酚、利尿等对症治疗。第5天出院,发病第12天CK恢复正常。结论副流感病毒是一种罕见的导致横纹肌溶解的原因。如果普通“感冒或流感”引起的肌痛发展为肌肉肿胀和压痛,特别是在下肢,并影响行动,应考虑紧急医疗评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rhabdomyolysis Induced by Parainfluenza 2 Virus in a Healthy 18-Year-Old Male Patient: A Case Study.

BACKGROUND Rhabdomyolysis is a medical condition characterized by the cellular breakdown of skeletal muscle tissue, leading to the release of basic muscle components into the bloodstream. Multiple causes have been reported, including infections that involve skeletal muscle cells. One of the most common classes of infections causing rhabdomyolysis is viral in origin. Clinically, the patient usually reports a short latency period consisting of malaise followed by muscle soreness, myalgia, and even an antalgic gait. Higher degrees of skeletal muscle damage result in higher levels of serum myoglobin. When the levels of myoglobin exceed the protein binding capacity, the molecule can precipitate during glomerular filtration and damage the kidneys. CASE REPORT An 18-year-old healthy, active male patient was brought to the Emergency Department (ED) after experiencing 5 days of generalized malaise and 2 days of progressively debilitating skeletal muscle pain and malfunction, leading to the inability to walk. He had dismissed the symptoms until he was non-ambulatory. On arrival at the ED, his creatine kinase (CK) level was elevated at 6859 U/L (reference, 10-70 U/L), and parainfluenza type 2 virus was identified by a nasopharyngeal respiratory polymerase chain reaction panel. He received symptomatic treatment including acetaminophen, methocarbamol, and diuresis. He was discharged on day 5, and his CK level returned to normal by day 12 of his disease. CONCLUSIONS Parainfluenza virus is a rare cause of rhabdomyolysis. If the myalgia of a common "cold or flu" progresses to muscle swelling and tenderness, especially in the lower extremities, and impairs ambulation, urgent medical evaluation should be considered.

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来源期刊
American Journal of Case Reports
American Journal of Case Reports Medicine-Medicine (all)
CiteScore
1.80
自引率
0.00%
发文量
599
期刊介绍: American Journal of Case Reports is an international, peer-reviewed scientific journal that publishes single and series case reports in all medical fields. American Journal of Case Reports is issued on a continuous basis as a primary electronic journal. Print copies of a single article or a set of articles can be ordered on demand.
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