{"title":"抗血管痉挛肥大细胞稳定剂：一种治疗过敏性反应引起的急性冠状动脉综合征的新方法。","authors":"Itsuro Kazama","doi":"10.7774/cevr.2025.14.e16","DOIUrl":null,"url":null,"abstract":"<p><p>Kounis syndrome is an acute myocardial infarction caused by severe allergic reactions or anaphylaxis following vaccination and other triggers, with the associated release of chemical mediators from mast cells causing coronary artery vasospasm. However, treatment with adrenaline is controversial as it paradoxically aggravates cardiac ischemia. Among the many a<sub>1</sub>-adrenergic receptor blockers, calcium channel blockers, endogenous vasodilators, and antioxidants that can ameliorate coronary artery vasospasm are some (e.g., prazosin, verapamil, diltiazem, magnesium and vitamin C) that can also stabilize mast cells. Given their dual pharmacological efficacies, these substances may be valuable treatments for Kounis syndrome following coronavirus disease 2019 and other vaccinations.</p>","PeriodicalId":51768,"journal":{"name":"Clinical and Experimental Vaccine Research","volume":"14 2","pages":"185-188"},"PeriodicalIF":2.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046083/pdf/","citationCount":"0","resultStr":"{\"title\":\"Anti-vasospastic mast cell stabilizers: a novel therapeutic approach to anaphylaxis-induced acute coronary syndrome.\",\"authors\":\"Itsuro Kazama\",\"doi\":\"10.7774/cevr.2025.14.e16\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Kounis syndrome is an acute myocardial infarction caused by severe allergic reactions or anaphylaxis following vaccination and other triggers, with the associated release of chemical mediators from mast cells causing coronary artery vasospasm. However, treatment with adrenaline is controversial as it paradoxically aggravates cardiac ischemia. Among the many a<sub>1</sub>-adrenergic receptor blockers, calcium channel blockers, endogenous vasodilators, and antioxidants that can ameliorate coronary artery vasospasm are some (e.g., prazosin, verapamil, diltiazem, magnesium and vitamin C) that can also stabilize mast cells. Given their dual pharmacological efficacies, these substances may be valuable treatments for Kounis syndrome following coronavirus disease 2019 and other vaccinations.</p>\",\"PeriodicalId\":51768,\"journal\":{\"name\":\"Clinical and Experimental Vaccine Research\",\"volume\":\"14 2\",\"pages\":\"185-188\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046083/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Vaccine Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7774/cevr.2025.14.e16\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Vaccine Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7774/cevr.2025.14.e16","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Anti-vasospastic mast cell stabilizers: a novel therapeutic approach to anaphylaxis-induced acute coronary syndrome.
Kounis syndrome is an acute myocardial infarction caused by severe allergic reactions or anaphylaxis following vaccination and other triggers, with the associated release of chemical mediators from mast cells causing coronary artery vasospasm. However, treatment with adrenaline is controversial as it paradoxically aggravates cardiac ischemia. Among the many a1-adrenergic receptor blockers, calcium channel blockers, endogenous vasodilators, and antioxidants that can ameliorate coronary artery vasospasm are some (e.g., prazosin, verapamil, diltiazem, magnesium and vitamin C) that can also stabilize mast cells. Given their dual pharmacological efficacies, these substances may be valuable treatments for Kounis syndrome following coronavirus disease 2019 and other vaccinations.
期刊介绍：
Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
