抗血管痉挛肥大细胞稳定剂:一种治疗过敏性反应引起的急性冠状动脉综合征的新方法。

IF 2.1 Q4 IMMUNOLOGY
Clinical and Experimental Vaccine Research Pub Date : 2025-04-01 Epub Date: 2025-03-25 DOI:10.7774/cevr.2025.14.e16
Itsuro Kazama
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引用次数: 0

摘要

Kounis综合征是一种急性心肌梗死,由疫苗接种和其他诱因引起的严重过敏反应或过敏反应引起,肥大细胞释放化学介质引起冠状动脉血管痉挛。然而,肾上腺素治疗是有争议的,因为它矛盾地加重了心脏缺血。在许多能改善冠状动脉血管痉挛的a1-肾上腺素受体阻滞剂、钙通道阻滞剂、内源性血管扩张剂和抗氧化剂中,有一些(如普拉唑嗪、维拉帕米、地尔硫卓、镁和维生素C)也能稳定肥大细胞。鉴于其双重药理功效,这些物质可能是2019冠状病毒病和其他疫苗接种后库尼斯综合征的有价值的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-vasospastic mast cell stabilizers: a novel therapeutic approach to anaphylaxis-induced acute coronary syndrome.

Kounis syndrome is an acute myocardial infarction caused by severe allergic reactions or anaphylaxis following vaccination and other triggers, with the associated release of chemical mediators from mast cells causing coronary artery vasospasm. However, treatment with adrenaline is controversial as it paradoxically aggravates cardiac ischemia. Among the many a1-adrenergic receptor blockers, calcium channel blockers, endogenous vasodilators, and antioxidants that can ameliorate coronary artery vasospasm are some (e.g., prazosin, verapamil, diltiazem, magnesium and vitamin C) that can also stabilize mast cells. Given their dual pharmacological efficacies, these substances may be valuable treatments for Kounis syndrome following coronavirus disease 2019 and other vaccinations.

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来源期刊
CiteScore
3.70
自引率
3.70%
发文量
29
审稿时长
8 weeks
期刊介绍: Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide
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