非高密度脂蛋白与高密度脂蛋白胆固醇比率作为糖尿病视网膜病变风险的预测性生物标志物：一项基于美国成年人的人群分析

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2025-01-01 Epub Date: 2025-04-14 DOI:10.1159/000545816

Zhirui Zhang, Changxing Liu, Lingying Zhao, Xufang Tan, Ximing Yu, Jiadi Wang, Jing Yao

{"title":"非高密度脂蛋白与高密度脂蛋白胆固醇比率作为糖尿病视网膜病变风险的预测性生物标志物：一项基于美国成年人的人群分析","authors":"Zhirui Zhang, Changxing Liu, Lingying Zhao, Xufang Tan, Ximing Yu, Jiadi Wang, Jing Yao","doi":"10.1159/000545816","DOIUrl":null,"url":null,"abstract":"Introduction: Diabetic retinopathy (DR) is a severe complication of diabetes, and lipid imbalances play a key role in its progression. The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) has been identified as a predictor of cardiovascular diseases, but its link to DR remains unclear. This study aimed to assess the association between NHHR and DR risk in diabetic patients.Methods: Data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Multivariate logistic regression models were used to evaluate the relationship between NHHR and DR. Nonlinear associations were assessed using restricted cubic spline analysis.Results: Of the 4,935 participants, 1,193 had DR. Higher NHHR was strongly associated with increased DR risk. Each unit rise in NHHR increased the risk by 19% (OR = 1.19, 95% CI: 1.07-1.31, p < 0.05). In quartile analysis, participants in the highest NHHR quartile had nearly double the risk of DR compared to those in the lowest quartile (OR = 1.84, 95% CI: 1.62-2.06, p < 0.001). Subgroup analysis showed this association was consistent across different demographic groups, including age, gender, BMI, and smoking status.Conclusion: NHHR is significantly linked to DR risk in diabetic patients and may be a valuable biomarker for early detection and prevention strategies in clinical settings.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"301-309"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-High-Density Lipoprotein-to-High-Density Lipoprotein Cholesterol Ratio as a Predictive Biomarker for Diabetic Retinopathy Risk: A Population-Based Analysis of US Adults.\",\"authors\":\"Zhirui Zhang, Changxing Liu, Lingying Zhao, Xufang Tan, Ximing Yu, Jiadi Wang, Jing Yao\",\"doi\":\"10.1159/000545816\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Diabetic retinopathy (DR) is a severe complication of diabetes, and lipid imbalances play a key role in its progression. The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) has been identified as a predictor of cardiovascular diseases, but its link to DR remains unclear. This study aimed to assess the association between NHHR and DR risk in diabetic patients.Methods: Data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Multivariate logistic regression models were used to evaluate the relationship between NHHR and DR. Nonlinear associations were assessed using restricted cubic spline analysis.Results: Of the 4,935 participants, 1,193 had DR. Higher NHHR was strongly associated with increased DR risk. Each unit rise in NHHR increased the risk by 19% (OR = 1.19, 95% CI: 1.07-1.31, p < 0.05). In quartile analysis, participants in the highest NHHR quartile had nearly double the risk of DR compared to those in the lowest quartile (OR = 1.84, 95% CI: 1.62-2.06, p < 0.001). Subgroup analysis showed this association was consistent across different demographic groups, including age, gender, BMI, and smoking status.Conclusion: NHHR is significantly linked to DR risk in diabetic patients and may be a valuable biomarker for early detection and prevention strategies in clinical settings.\",\"PeriodicalId\":19662,\"journal\":{\"name\":\"Ophthalmic Research\",\"volume\":\" \",\"pages\":\"301-309\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000545816\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545816","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：糖尿病视网膜病变（DR）是糖尿病的严重并发症，脂质失衡在其进展中起关键作用。非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率（NHHR）已被确定为心血管疾病的预测因子，但其与DR的关系尚不清楚。目的：本研究旨在评估糖尿病患者NHHR与DR风险的关系。方法：对2005-2018年全国健康与营养检查调查（NHANES）数据进行分析。采用多变量logistic回归模型评估NHHR与dr之间的关系，非线性关联采用限制三次样条分析进行评估。结果：在4935名参与者中，1193名患有DR。较高的NHHR与DR风险增加密切相关。NHHR每升高一个单位，风险增加19% （OR = 1.19, 95% CI: 1.07 ~ 1.31, P < 0.05）。在四分位数分析中，与最低四分位数相比，最高NHHR四分位数的参与者发生DR的风险几乎是最低四分位数的两倍（OR = 1.84, 95% CI: 1.62-2.06, P < 0.001）。亚组分析显示，这种关联在不同的人口统计群体中是一致的，包括年龄、性别、体重指数和吸烟状况。结论：NHHR与糖尿病患者的DR风险显著相关，可能是临床早期发现和预防策略的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Non-High-Density Lipoprotein-to-High-Density Lipoprotein Cholesterol Ratio as a Predictive Biomarker for Diabetic Retinopathy Risk: A Population-Based Analysis of US Adults.

Introduction: Diabetic retinopathy (DR) is a severe complication of diabetes, and lipid imbalances play a key role in its progression. The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) has been identified as a predictor of cardiovascular diseases, but its link to DR remains unclear. This study aimed to assess the association between NHHR and DR risk in diabetic patients.

Methods: Data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Multivariate logistic regression models were used to evaluate the relationship between NHHR and DR. Nonlinear associations were assessed using restricted cubic spline analysis.

Results: Of the 4,935 participants, 1,193 had DR. Higher NHHR was strongly associated with increased DR risk. Each unit rise in NHHR increased the risk by 19% (OR = 1.19, 95% CI: 1.07-1.31, p < 0.05). In quartile analysis, participants in the highest NHHR quartile had nearly double the risk of DR compared to those in the lowest quartile (OR = 1.84, 95% CI: 1.62-2.06, p < 0.001). Subgroup analysis showed this association was consistent across different demographic groups, including age, gender, BMI, and smoking status.

Conclusion: NHHR is significantly linked to DR risk in diabetic patients and may be a valuable biomarker for early detection and prevention strategies in clinical settings.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.