Ziyue Liu, Jintao Yuan, Lan Wang, Muhammad AzharUd Din, Yiqing Tian, Fei Mao
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PLGA-hucMSC-Ex Ameliorates Colitis by Reversing Epithelial-mesenchymal Transition.
Introduction: Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Exs) have been found to exhibit therapeutic effects on inflammatory bowel disease (IBD). However, due to the harsh environment of the gastrointestinal tract, exosomes, as a type of biological drug or carrier of bio-active substances, are still delivered by tail vein injection.
Method: In this study, hucMSC-Ex were coated with poly (lactic-co-glycolic acid) (PLGA) polymer to form microparticles, PLGA-hucMSC-Ex, by double emulsion method.
Results: The oral administration of PLGA-hucMSC-Ex particles alleviated inflammation in the mice model of IBD by reversing IBD-induced epithelial-mesenchymal transition (EMT).
Conclusion: This provides an alternative to exploring IBD treatments, with potential clinical application to relieve IBD in patients.
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