{"title":"银基敷料预防手术部位感染：来自随机试验的证据。","authors":"Salma Younes, Nadin Younes, Shaden Abunasser, Faleh Tamimi, Gheyath Nasrallah","doi":"10.1016/j.jhin.2025.04.026","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Surgical site infections (SSIs) are a major cause of postoperative complications, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their antimicrobial properties, but their effectiveness in reducing SSIs remains unclear.</p><p><strong>Aim: </strong>This systematic review and meta-analysis aim to evaluate the efficacy of silver-based dressings compared to non-silver dressings in preventing SSIs in randomized controlled trials (RCTs) METHODS: A systematic search was conducted in PubMed, Cochrane Library, and Embase to identify RCTs comparing silver-based to non-silver dressings for SSI prevention. The study protocol was registered in PROSPERO (CRD42024592966). Meta-analysis using random-effects models calculated pooled risk ratios (RR) with 95% confidence intervals (CI). Heterogeneity was assessed with the I<sup>2</sup> statistic, and publication bias evaluated through funnel plots and Egger's test.</p><p><strong>Results: </strong>12 RCTs with 2,928 participants were included in the meta-analysis. Silver-based dressings significantly reduced SSI risk by 40% compared to non-silver dressings (RR: 0.60, 95% CI: 0.41-0.89, p<0.05), with moderate heterogeneity (I<sup>2</sup> = 53%) CONCLUSIONS: : Silver-based dressings significantly reduce the risk of SSIs; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Silver-Based Dressings for Surgical Site Infection Prevention: Evidence from Randomized Trials.\",\"authors\":\"Salma Younes, Nadin Younes, Shaden Abunasser, Faleh Tamimi, Gheyath Nasrallah\",\"doi\":\"10.1016/j.jhin.2025.04.026\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Surgical site infections (SSIs) are a major cause of postoperative complications, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their antimicrobial properties, but their effectiveness in reducing SSIs remains unclear.</p><p><strong>Aim: </strong>This systematic review and meta-analysis aim to evaluate the efficacy of silver-based dressings compared to non-silver dressings in preventing SSIs in randomized controlled trials (RCTs) METHODS: A systematic search was conducted in PubMed, Cochrane Library, and Embase to identify RCTs comparing silver-based to non-silver dressings for SSI prevention. The study protocol was registered in PROSPERO (CRD42024592966). Meta-analysis using random-effects models calculated pooled risk ratios (RR) with 95% confidence intervals (CI). Heterogeneity was assessed with the I<sup>2</sup> statistic, and publication bias evaluated through funnel plots and Egger's test.</p><p><strong>Results: </strong>12 RCTs with 2,928 participants were included in the meta-analysis. Silver-based dressings significantly reduced SSI risk by 40% compared to non-silver dressings (RR: 0.60, 95% CI: 0.41-0.89, p<0.05), with moderate heterogeneity (I<sup>2</sup> = 53%) CONCLUSIONS: : Silver-based dressings significantly reduce the risk of SSIs; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.</p>\",\"PeriodicalId\":54806,\"journal\":{\"name\":\"Journal of Hospital Infection\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hospital Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhin.2025.04.026\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hospital Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhin.2025.04.026","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Silver-Based Dressings for Surgical Site Infection Prevention: Evidence from Randomized Trials.
Background: Surgical site infections (SSIs) are a major cause of postoperative complications, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their antimicrobial properties, but their effectiveness in reducing SSIs remains unclear.
Aim: This systematic review and meta-analysis aim to evaluate the efficacy of silver-based dressings compared to non-silver dressings in preventing SSIs in randomized controlled trials (RCTs) METHODS: A systematic search was conducted in PubMed, Cochrane Library, and Embase to identify RCTs comparing silver-based to non-silver dressings for SSI prevention. The study protocol was registered in PROSPERO (CRD42024592966). Meta-analysis using random-effects models calculated pooled risk ratios (RR) with 95% confidence intervals (CI). Heterogeneity was assessed with the I2 statistic, and publication bias evaluated through funnel plots and Egger's test.
Results: 12 RCTs with 2,928 participants were included in the meta-analysis. Silver-based dressings significantly reduced SSI risk by 40% compared to non-silver dressings (RR: 0.60, 95% CI: 0.41-0.89, p<0.05), with moderate heterogeneity (I2 = 53%) CONCLUSIONS: : Silver-based dressings significantly reduce the risk of SSIs; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
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