Ben S Ashby, Veronika Chronholm, Daniel K Hajnal, Alex Lukyanov, Katherine MacKenzie, Aaron Pim, Tristan Pryer
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Efficient proton transport modelling for proton beam therapy and biological quantification.
In this work, we present a fundamental mathematical model for proton transport, tailored to capture the key physical processes underpinning Proton Beam Therapy (PBT). The model provides a robust and computationally efficient framework for exploring various aspects of PBT, including dose delivery, linear energy transfer, treatment planning and the evaluation of relative biological effectiveness. Our findings highlight the potential of this model as a complementary tool to more complex and computationally intensive simulation techniques currently used in clinical practice.
期刊介绍:
The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena.
Areas of biology covered include, but are not restricted to, cell biology, physiology, development, neurobiology, genetics and population genetics, population biology, ecology, behavioural biology, evolution, epidemiology, immunology, molecular biology, biofluids, DNA and protein structure and function. All mathematical approaches including computational and visualization approaches are appropriate.