儿童和青少年接受生长激素治疗的颅面改变:一项系统综述。

IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Raul Borges Nascimento, Suelly Maria Mendes Ribeiro, Nathalia Carolina Fernandes Fagundes, David Normando
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引用次数: 0

摘要

本系统综述的目的是调查儿童和青少年生长激素缺乏或特发性身材矮小(ISS)的颅面变化与生长激素(GH)治疗之间的关系。审查的所有阶段都遵循PRISMA指南。在七个数据库中进行了电子搜索,没有年份或语言限制。研究选择分两个阶段由两个校准的审查员进行。研究在儿童和青少年生长激素缺乏或ISS接受生长激素治疗颅面变化。数据提取后,使用乔安娜布里格斯研究所(JBI)关键评估工具和RoB 2.0检查表评估偏倚风险。使用GRADE工具评估证据的确定性。在4494条被引用的文献中,有7项研究符合入选标准。这些研究评估了GHs对头颅测量和牙龄的影响。即刻和延迟治疗在上颌和下颌尺寸上没有差异。所有入选文章均显示低偏倚风险。所有评估结果的证据确定性都很低。生长激素治疗似乎导致下颌尺寸的小增加,虽然没有临床意义的特点,不良反应。需要对这些患者进行临床试验和长期随访研究,以就GHs在颅面区域的影响提出准确的建议。生长激素可能导致下颌和上颌尺寸的轻微增加,对一般健康没有明显的不利影响。需要长期随访的对照干预研究来建立更精确的建议。试验注册:PROSPERO数据库(https://www.crd.york.ac.uk/prospero/): CRD42024511329。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Craniofacial Changes Among Children and Adolescents Submitted to Growth Hormone Therapy: A Systematic Review.

The aim of this systematic review was to investigate the association between craniofacial changes and growth hormone (GH) therapy among children and adolescents with GH deficiency or idiopathic short stature (ISS). The PRISMA guideline was followed to carry out all stages of this review. An electronic search was conducted in seven databases, without year or language restrictions. The study selection was carried out in two stages by two calibrated examiners. Studies exploring craniofacial changes among children and adolescents with GH deficiency or ISS undergoing GH therapy were included. After data extraction, the risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tool and the RoB 2.0 Checklist. The certainty of the evidence was assessed using the GRADE tool. Among the 4494 identified citations, seven studies met the eligibility criteria. These studies evaluated the impact of GHs on cephalometric measurements and dental age. No differences between immediate and delayed treatments were found in maxillary and mandibular dimensions. All selected articles showed a low risk of bias. A low certainty of evidence was observed for all outcomes assessed. GH therapy appears to result in a small increase in mandibular dimensions, although without clinical significance characteristic of adverse effects. Clinical trials and long-term follow-up studies of these patients are needed to develop accurate recommendations regarding the effects of GHs in the craniofacial region. Growth hormone may result in a slight increase in mandibular and maxillary dimensions, without significant adverse effects to general health. Controlled intervention studies with long-term follow-up are needed to establish more precise recommendations. Trial Registration: PROSPERO database (https://www.crd.york.ac.uk/prospero/): CRD42024511329.

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来源期刊
Orthodontics & Craniofacial Research
Orthodontics & Craniofacial Research 医学-牙科与口腔外科
CiteScore
5.30
自引率
3.20%
发文量
65
审稿时长
>12 weeks
期刊介绍: Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions. The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements. The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.
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