Salvador Domènech-Montoliu, Laura López-Diago, Isabel Aleixandre-Gorriz, Óscar Pérez-Olaso, Diego Sala-Trull, Alba Del Rio-González, Maria Rosario Pac-Sa, Manuel Sánchez-Urbano, Paloma Satorres-Martinez, Juan Casanova-Suarez, Cristina Notari-Rodriguez, Raquel Ruiz-Puig, Gema Badenes-Marques, Laura Aparisi-Esteve, Carmen Domènech-León, Maria Angeles Romeu-Garcia, Alberto Arnedo-Pena
{"title":"Borriana COVID-19队列中维生素D状况和SARS-CoV-2再感染发生率：一项基于人群的前瞻性队列研究","authors":"Salvador Domènech-Montoliu, Laura López-Diago, Isabel Aleixandre-Gorriz, Óscar Pérez-Olaso, Diego Sala-Trull, Alba Del Rio-González, Maria Rosario Pac-Sa, Manuel Sánchez-Urbano, Paloma Satorres-Martinez, Juan Casanova-Suarez, Cristina Notari-Rodriguez, Raquel Ruiz-Puig, Gema Badenes-Marques, Laura Aparisi-Esteve, Carmen Domènech-León, Maria Angeles Romeu-Garcia, Alberto Arnedo-Pena","doi":"10.3390/tropicalmed10040098","DOIUrl":null,"url":null,"abstract":"<p><p>A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this status related to SARS-CoV-2 reinfections has been studied little. Our aim was to quantify the risk of reinfections considering VitD status before reinfection.</p><p><strong>Methods: </strong>We performed a population-based prospective cohort study in Borriana (Valencia Community, Spain) during 2020-2023, measuring 25-hydroxyvitamin D [25(OH)D] levels by electrochemiluminescence. Cox proportional hazards models were employed.</p><p><strong>Results: </strong>Of a total of 644 SARS-CoV-2 cases with confirmed laboratory tests, 378 (58.9%) were included in our study, with an average age of 38.8 years; 241 were females (63.8%), and 127 reinfections occurred (33.6%). SARS-CoV-2 reinfection incidence rates per 1000 person-days by VitD status were 0.50 for a deficient status (<20 ng/mL), 0.50 for an insufficient status (20-29 ng/mL), and 0.37 for a sufficient status (≥30 ng/mL). Compared with a sufficient VitD status, adjusted hazard ratios were 1.79 (95% confidence interval [CI] 0.89-3.59) for a deficient status and 1.59 (95% CI 1.06-2.38) for an insufficient status with a significant inverse dose-response (<i>p</i> = 0.02). These results can help improve nutritional actions against SARS-CoV-2 reinfections.</p><p><strong>Conclusions: </strong>These results suggest that a VitD status lower than 30 ng/mL showed a higher risk of SARS-CoV-2 reinfection. Achieving and maintaining a sufficient VitD status is recommended to prevent reinfections.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":"10 4","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031365/pdf/","citationCount":"0","resultStr":"{\"title\":\"Vitamin D Status and Incidence of SARS-CoV-2 Reinfections in the Borriana COVID-19 Cohort: A Population-Based Prospective Cohort Study.\",\"authors\":\"Salvador Domènech-Montoliu, Laura López-Diago, Isabel Aleixandre-Gorriz, Óscar Pérez-Olaso, Diego Sala-Trull, Alba Del Rio-González, Maria Rosario Pac-Sa, Manuel Sánchez-Urbano, Paloma Satorres-Martinez, Juan Casanova-Suarez, Cristina Notari-Rodriguez, Raquel Ruiz-Puig, Gema Badenes-Marques, Laura Aparisi-Esteve, Carmen Domènech-León, Maria Angeles Romeu-Garcia, Alberto Arnedo-Pena\",\"doi\":\"10.3390/tropicalmed10040098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this status related to SARS-CoV-2 reinfections has been studied little. Our aim was to quantify the risk of reinfections considering VitD status before reinfection.</p><p><strong>Methods: </strong>We performed a population-based prospective cohort study in Borriana (Valencia Community, Spain) during 2020-2023, measuring 25-hydroxyvitamin D [25(OH)D] levels by electrochemiluminescence. Cox proportional hazards models were employed.</p><p><strong>Results: </strong>Of a total of 644 SARS-CoV-2 cases with confirmed laboratory tests, 378 (58.9%) were included in our study, with an average age of 38.8 years; 241 were females (63.8%), and 127 reinfections occurred (33.6%). SARS-CoV-2 reinfection incidence rates per 1000 person-days by VitD status were 0.50 for a deficient status (<20 ng/mL), 0.50 for an insufficient status (20-29 ng/mL), and 0.37 for a sufficient status (≥30 ng/mL). Compared with a sufficient VitD status, adjusted hazard ratios were 1.79 (95% confidence interval [CI] 0.89-3.59) for a deficient status and 1.59 (95% CI 1.06-2.38) for an insufficient status with a significant inverse dose-response (<i>p</i> = 0.02). These results can help improve nutritional actions against SARS-CoV-2 reinfections.</p><p><strong>Conclusions: </strong>These results suggest that a VitD status lower than 30 ng/mL showed a higher risk of SARS-CoV-2 reinfection. Achieving and maintaining a sufficient VitD status is recommended to prevent reinfections.</p>\",\"PeriodicalId\":23330,\"journal\":{\"name\":\"Tropical Medicine and Infectious Disease\",\"volume\":\"10 4\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031365/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tropical Medicine and Infectious Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/tropicalmed10040098\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropical Medicine and Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/tropicalmed10040098","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Vitamin D Status and Incidence of SARS-CoV-2 Reinfections in the Borriana COVID-19 Cohort: A Population-Based Prospective Cohort Study.
A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this status related to SARS-CoV-2 reinfections has been studied little. Our aim was to quantify the risk of reinfections considering VitD status before reinfection.
Methods: We performed a population-based prospective cohort study in Borriana (Valencia Community, Spain) during 2020-2023, measuring 25-hydroxyvitamin D [25(OH)D] levels by electrochemiluminescence. Cox proportional hazards models were employed.
Results: Of a total of 644 SARS-CoV-2 cases with confirmed laboratory tests, 378 (58.9%) were included in our study, with an average age of 38.8 years; 241 were females (63.8%), and 127 reinfections occurred (33.6%). SARS-CoV-2 reinfection incidence rates per 1000 person-days by VitD status were 0.50 for a deficient status (<20 ng/mL), 0.50 for an insufficient status (20-29 ng/mL), and 0.37 for a sufficient status (≥30 ng/mL). Compared with a sufficient VitD status, adjusted hazard ratios were 1.79 (95% confidence interval [CI] 0.89-3.59) for a deficient status and 1.59 (95% CI 1.06-2.38) for an insufficient status with a significant inverse dose-response (p = 0.02). These results can help improve nutritional actions against SARS-CoV-2 reinfections.
Conclusions: These results suggest that a VitD status lower than 30 ng/mL showed a higher risk of SARS-CoV-2 reinfection. Achieving and maintaining a sufficient VitD status is recommended to prevent reinfections.
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