Diagnostic Efficacy of Prostate Biopsy by Transperineal Colour Ultrasound Plus Magnetic Resonance Imaging for Prostate Cancer and Analysis of Oxidative Stress Injury in Patients.

Objective: This study aims to evaluate the diagnostic effectiveness of prostate biopsies using transperineal colour ultrasound with magnetic resonance imaging (MRI) against transrectal colour ultrasound with MRI in treating prostate cancer (PCa) and oxidative stress injuries in patients.

Methods: We conducted a backward-looking study on the medical records of 65 individuals suspected of having PCa who underwent prostate biopsies at our hospital from March 2022 to March 2024. In the transrectal prostate biopsy (TRPB) group, 32 patients underwent TRPB, whereas the transperineal prostate biopsy (TPPB) group utilised TPPB for 33 patients. Every patient received an MRI scan to verify the location of the puncture prior to it. The length of the puncture, the amount of biopsy cores collected and confirmed as positive and any negative responses postprocedure were thoroughly documented. The indices of oxidative stress injuries in both groups were assessed postpuncture, and the effectiveness levels of TPPB and TRPB in diagnosing PCa were compared.

Results: No significant statistical variance existed between the two groups in the count of biopsy and positive biopsy cores (p > 0.05). However, compared with the duration of puncture in the TRPB group, that in the TPPB group was extended (p < 0.05). No significant variance in oxidative stress damage postpuncture existed amongst the groups (p > 0.05), and the TPPB group experienced fewer negative reactions than the TRPB group (p < 0.05). In terms of diagnostic effectiveness, TPPB's sensitivity, specificity and accuracy in detecting PCa stood at 84.62%, 85.00% and 84.85%, respectively, surpassing those of TRPB in Kappa value. Additionally, the overall prostate-specific antigen levels in the TPPB group's genuinely positive patients were notably less than those in the TRPB group (p < 0.05).

Conclusions: The combination of transperineal colour ultrasound and MRI is highly efficient in PCa diagnosis and is advised as the primary option in clinical settings.