[抗逆转录病毒治疗依从性及其与抑郁、焦虑和压力的关系]。

Carla Gabriela Guzmán-Mendoza, María Del Carmen Jiménez-González, Oscar Manuel Delgado-Cuellar, Iván de Jesús Ascencio-Montiel
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引用次数: 0

摘要

背景:压力、焦虑和抑郁与HIV患者抗逆转录病毒治疗(ART)依从性低有关,但在墨西哥东南部没有这种关联的报道。目的:描述坚持抗逆转录病毒治疗的频率及其与抑郁、焦虑和压力的关系。材料与方法:采用横断面研究。对2022年8月至12月期间在恰帕斯州塔帕丘拉第一综合医院接受治疗的442名艾滋病毒阳性门诊患者进行了分析。采用简化药物依从性问卷(SMAQ)和抑郁、焦虑和压力量表-21 (DASS-21)评估抗逆转录病毒治疗的依从性。为了评估变量之间的相关性,使用多变量logistic回归模型计算校正优势比(aOR)和95%置信区间(CI)。治疗依从性在95%至100%之间的病例与治疗依从性在95%以下的病例进行比较。结果:在442名hiv阳性受试者中,344名ART依从性在95% - 100%之间,98名ART依从性低于95%。抑郁、焦虑和压力的频率分别为33%、13.3%和8.8%。观察到抗逆转录病毒治疗依从性低于95%与焦虑、抑郁和压力之间存在关联。结论:由于抗逆转录病毒治疗依从性低与艾滋病毒阳性患者的抑郁、焦虑和压力有关,早期心理健康干预可能有助于提高治疗依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[ART adherence and its association with depression, anxiety and stress].

Background: Stress, anxiety, and depression are associated with low adherence to antiretroviral therapy (ART) in HIV patients, but there are no reports of this association in southeastern Mexico.

Objective: To describe the frequency of adherence to ART and its association with depression, anxiety, and stress.

Material and methods: A cross-sectional study was conducted. 442 HIV-positive outpatients treated at General Hospital Number 1 in Tapachula, Chiapas, in the period August-December 2022 were analyzed. Adherence to ART was assessed with the Simplified Medication Adherence Questionnaire (SMAQ) and the Depression, Anxiety, and Stress Scale-21 (DASS-21) was applied. To assess the association between variables, adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated using a multivariate logistic regression model. Cases with ART adherence between 95% and 100% were compared with those with ART adherence below 95%.

Results: Of the total 442 HIV-positive subjects, 344 had ART adherence between 95% and 100%, and 98 had ART adherence below 95%. The frequencies of depression, anxiety, and stress were 33%, 13.3%, and 8.8%, respectively. Associations were observed between ART adherence below 95% and anxiety, depression, and stress.

Conclusions: Since low ART adherence was associated with depression, anxiety, and stress among HIV-positive patients, early mental health interventions may help improve therapeutic adherence.

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