{"title":"Al18F-NOTA-FAPI-04 PET/CT在强直性脊柱炎治疗中的初步探讨：一项前瞻性临床研究。","authors":"Shibo Guo, Zhehao Lyu, Chunyu Duan, Hui Wang, Peng Xu, Wei Han, Peng Fu","doi":"10.1177/15353508241270405","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the progression of disease activity and assisting in evaluating the efficacy of the treatment.</p><p><strong>Objective: </strong>The study was to evaluate the diagnostic value of aluminium-[<sup>18</sup>F]fuoride(Al<sup>18</sup>F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS.</p><p><strong>Material and methods: </strong>Twenty AS participants who met the Assessment of SpondyloArthritis international Society criteria and were in an active disease stage were included in this study from May 2022 to April 2023. Sixteen healthy controls were also inrolled. All participants underwent Al<sup>18</sup>F-NOTA-FAPI-04 PET/CT imaging after collecting clinical assessment and laboratory results. The correlation between positive joint count (PJC) and systemic joint standard uptake value ratio (SUVR, the mean SUV<sub>max</sub> of the 5 highest joints/SUV<sub>max</sub> of the uninvolved sacrum) on PET and clinical disease activity assessment and various laboratory tests were analyzed.</p><p><strong>Results: </strong>A total of 2820 joints were observed in 20 participants (median age 34.5,[21-61]range, 15 men), with a PJC of 1300 (46.7%), and 39 positive uptakes were found in 40 sacroiliac joints (97.5%). PET/CT images revealed FAPI-04 uptake in both sacroiliac joints in 2 participants without radiographic sacroiliitis in the early stages of AS and varying degrees of uptake in the sacroiliac joints and spinal joints in the remaining participants. PJC and SUVR were positively correlated with most clinical assessments and laboratory findings (<i>P </i>< .05), and SUVR of the sacroiliac joint was positively correlated with C-reactive protein (CRP) (mg/L; r = 0.498, <i>P </i>= .026).</p><p><strong>Conclusion: </strong>Al<sup>18</sup>F-NOTA-FAPI-04 PET/CT was highly sensitive to systemic arthritic changes in AS participants and correlated with clinical disease activity and laboratory tests.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"23 ","pages":"15353508241270405"},"PeriodicalIF":2.2000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995437/pdf/","citationCount":"0","resultStr":"{\"title\":\"Preliminary Exploration of Al<sup>18</sup>F-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study.\",\"authors\":\"Shibo Guo, Zhehao Lyu, Chunyu Duan, Hui Wang, Peng Xu, Wei Han, Peng Fu\",\"doi\":\"10.1177/15353508241270405\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the progression of disease activity and assisting in evaluating the efficacy of the treatment.</p><p><strong>Objective: </strong>The study was to evaluate the diagnostic value of aluminium-[<sup>18</sup>F]fuoride(Al<sup>18</sup>F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS.</p><p><strong>Material and methods: </strong>Twenty AS participants who met the Assessment of SpondyloArthritis international Society criteria and were in an active disease stage were included in this study from May 2022 to April 2023. Sixteen healthy controls were also inrolled. All participants underwent Al<sup>18</sup>F-NOTA-FAPI-04 PET/CT imaging after collecting clinical assessment and laboratory results. The correlation between positive joint count (PJC) and systemic joint standard uptake value ratio (SUVR, the mean SUV<sub>max</sub> of the 5 highest joints/SUV<sub>max</sub> of the uninvolved sacrum) on PET and clinical disease activity assessment and various laboratory tests were analyzed.</p><p><strong>Results: </strong>A total of 2820 joints were observed in 20 participants (median age 34.5,[21-61]range, 15 men), with a PJC of 1300 (46.7%), and 39 positive uptakes were found in 40 sacroiliac joints (97.5%). PET/CT images revealed FAPI-04 uptake in both sacroiliac joints in 2 participants without radiographic sacroiliitis in the early stages of AS and varying degrees of uptake in the sacroiliac joints and spinal joints in the remaining participants. PJC and SUVR were positively correlated with most clinical assessments and laboratory findings (<i>P </i>< .05), and SUVR of the sacroiliac joint was positively correlated with C-reactive protein (CRP) (mg/L; r = 0.498, <i>P </i>= .026).</p><p><strong>Conclusion: </strong>Al<sup>18</sup>F-NOTA-FAPI-04 PET/CT was highly sensitive to systemic arthritic changes in AS participants and correlated with clinical disease activity and laboratory tests.</p>\",\"PeriodicalId\":18855,\"journal\":{\"name\":\"Molecular Imaging\",\"volume\":\"23 \",\"pages\":\"15353508241270405\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995437/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15353508241270405\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15353508241270405","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
摘要
背景：强直性脊柱炎（AS）以骶髂关节炎症和成骨细胞改变为特征。正电子发射断层扫描（PET）作为一种潜在的早期评估As的成像方法，可以量化全身性疾病活动性，有利于监测疾病活动性的进展，协助评估治疗效果。目的：评价铝-[18F]氟化物（Al18F）标记成纤维细胞活化蛋白抑制剂（FAPI） PET/ CT在AS中的诊断价值，探讨其在AS发展过程中评估疾病活动性的能力。材料和方法：在2022年5月至2023年4月期间，20名符合国际脊椎关节炎评估协会（Assessment of SpondyloArthritis international Society）标准且处于活动性疾病阶段的AS参与者被纳入本研究。16名健康对照者也参与其中。在收集临床评估和实验室结果后，所有参与者都进行了Al18F-NOTA-FAPI-04 PET/CT成像。分析关节阳性计数（PJC）与全身关节标准摄取值比（SUVR， 5个最高关节的平均SUVmax /未受累骶骨SUVmax）在PET、临床疾病活动性评估和各项实验室检查中的相关性。结果：20名参与者（中位年龄34.5岁，[21-61]范围，15名男性）共观察到2820个关节，PJC为1300(46.7%)，40个骶髂关节中发现39个阳性摄取（97.5%）。PET/CT图像显示，2名早期无骶髂炎的患者骶髂关节均有FAPI-04摄取，其余患者骶髂关节和脊柱关节均有不同程度的摄取。PJC和SUVR与大多数临床评估和实验室结果呈正相关（P P = 0.026）。结论：Al18F-NOTA-FAPI-04 PET/CT对AS参与者的全身关节炎变化高度敏感，并与临床疾病活动性和实验室检查相关。
Preliminary Exploration of Al18F-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study.
Background: Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the progression of disease activity and assisting in evaluating the efficacy of the treatment.
Objective: The study was to evaluate the diagnostic value of aluminium-[18F]fuoride(Al18F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS.
Material and methods: Twenty AS participants who met the Assessment of SpondyloArthritis international Society criteria and were in an active disease stage were included in this study from May 2022 to April 2023. Sixteen healthy controls were also inrolled. All participants underwent Al18F-NOTA-FAPI-04 PET/CT imaging after collecting clinical assessment and laboratory results. The correlation between positive joint count (PJC) and systemic joint standard uptake value ratio (SUVR, the mean SUVmax of the 5 highest joints/SUVmax of the uninvolved sacrum) on PET and clinical disease activity assessment and various laboratory tests were analyzed.
Results: A total of 2820 joints were observed in 20 participants (median age 34.5,[21-61]range, 15 men), with a PJC of 1300 (46.7%), and 39 positive uptakes were found in 40 sacroiliac joints (97.5%). PET/CT images revealed FAPI-04 uptake in both sacroiliac joints in 2 participants without radiographic sacroiliitis in the early stages of AS and varying degrees of uptake in the sacroiliac joints and spinal joints in the remaining participants. PJC and SUVR were positively correlated with most clinical assessments and laboratory findings (P < .05), and SUVR of the sacroiliac joint was positively correlated with C-reactive protein (CRP) (mg/L; r = 0.498, P = .026).
Conclusion: Al18F-NOTA-FAPI-04 PET/CT was highly sensitive to systemic arthritic changes in AS participants and correlated with clinical disease activity and laboratory tests.
Molecular ImagingBiochemistry, Genetics and Molecular Biology-Biotechnology
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3.60%
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21
期刊介绍：
Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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