{"title":"通过肠道微生物来源的胆汁酸和血小板活化对血栓形成的看法。","authors":"Cristina Menni, Ana M. Valdes","doi":"10.1038/s44161-025-00634-0","DOIUrl":null,"url":null,"abstract":"Cardiovascular arterial thrombosis poses a major health burden, despite intensive antiplatelet therapy, and platelet hyper-reactivity drives thrombus formation, yet its molecular mechanisms remain unknown. A study now shows that gut microbiota–derived deoxycholic acid modulates platelet activity and thrombosis risk in coronary artery disease.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"505-507"},"PeriodicalIF":10.8000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation\",\"authors\":\"Cristina Menni, Ana M. Valdes\",\"doi\":\"10.1038/s44161-025-00634-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cardiovascular arterial thrombosis poses a major health burden, despite intensive antiplatelet therapy, and platelet hyper-reactivity drives thrombus formation, yet its molecular mechanisms remain unknown. A study now shows that gut microbiota–derived deoxycholic acid modulates platelet activity and thrombosis risk in coronary artery disease.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 5\",\"pages\":\"505-507\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00634-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00634-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation
Cardiovascular arterial thrombosis poses a major health burden, despite intensive antiplatelet therapy, and platelet hyper-reactivity drives thrombus formation, yet its molecular mechanisms remain unknown. A study now shows that gut microbiota–derived deoxycholic acid modulates platelet activity and thrombosis risk in coronary artery disease.
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