波斯尼亚和黑塞哥维那联邦在四波大流行期间的SARS-CoV-2变体概述。

IF 1.8 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Ivana Čeko, Naida Mulahuseinović, Selma Durgut, Lana Salihefendić, Adna Ašić, Dino Pećar, Nejira Handžić, Sabina Šegalo, Lejla Lasić, Rijad Konjhodžić
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引用次数: 0

摘要

由SARS-CoV-2引起的covid -19大流行对全球卫生产生了深远影响,包括在波斯尼亚和黑塞哥维那,由于检测有限和死亡率高,该国面临着独特的挑战。该分析旨在识别突变并检测四波大流行中不同的SARS-CoV-2谱系。方法收集波斯尼亚和黑塞哥维那联邦患者的127份SARS-CoV-2样本并进行测序,全面了解该地区的病毒遗传多样性。使用Ion Torrent和Illumina两个测序平台,其中37个样品在Ion Torrent平台上测序,其余样品在Illumina平台上测序。本研究对波斯尼亚和黑塞哥维那联邦在2020年3月至2023年4月的四次不同大流行浪潮中流行的SARS-CoV-2变体进行了基因组分析。对这些波的基因组变异的检查揭示了与传播和潜在毒力相关的关键突变。结论这些关于波斯尼亚和黑塞哥维那联邦SARS-CoV-2进化的基因组见解强调了持续监测对了解病毒进化和加强公共卫生应对未来大流行的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Overview of SARS-CoV-2 variants in the federation of Bosnia and Herzegovina throughout four waves of the pandemic.

AimCOVID-19 pandemic, caused by SARS-CoV-2, has had a profound impact on global health, including in Bosnia and Herzegovina, which faced unique challenges due to limited testing and high mortality rates. This analysis aimed to identify mutations and detect different SARS-CoV-2 lineages across four pandemic waves.MethodologyA total of 127 SARS-CoV-2 samples were collected and sequenced from patients from the Federation of Bosnia and Herzegovina, providing a comprehensive overview of the viral genetic diversity in this region. Two sequencing platforms, Ion Torrent and Illumina, were used, whereby 37 samples were sequenced on the Ion Torrent platform, while others were sequenced on the Illumina platform.ResultsThis study presents a genomic analysis of SARS-CoV-2 variants circulating in the Federation of Bosnia and Herzegovina over four distinct pandemic waves, spanning from March 2020 to April 2023. Examination of genomic variations across these waves revealed key mutations associated with transmission and potential virulence.ConclusionThese genomic insights into SARS-CoV-2 evolution in Federation of Bosnia and Herzegovina emphasizes the importance of continuous surveillance to understand viral evolution and strengthen public health responses to future pandemics.

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来源期刊
Technology and Health Care
Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL
CiteScore
2.10
自引率
6.20%
发文量
282
审稿时长
>12 weeks
期刊介绍: Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered: 1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables. 2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words. Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics. 4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors. 5.Letters to the Editors: Discussions or short statements (not indexed).
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