肌动蛋白捆绑蛋白,筋膜蛋白-1,作为骨关节炎进展的靶标。

Rylee E King, Marin Herrick, Justin Parreno
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引用次数: 0

摘要

骨关节炎发病的细胞机制尚不完全清楚。然而,最近的体内和体外研究表明,肌动蛋白细胞骨架重组在骨关节炎的进展中起着关键作用。已有研究表明,靶向抑制肌动蛋白捆绑蛋白(fastin)是重组肌动蛋白和防止骨关节炎中发生的软骨细胞去分化的有利途径。在骨关节炎的外科模型中,靶向筋膜蛋白可减少软骨退化和疾病严重程度。这些发现突出了靶向筋膜蛋白治疗骨关节炎的潜力。未来的研究将进一步了解肌动蛋白和肌动蛋白网络分子在骨关节炎中的关键作用,这可能会导致基于肌动蛋白的治疗疾病进展的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Actin-Bundling Protein, Fascin-1, as a Target of Osteoarthritis Progression.

The cellular mechanisms underlying osteoarthritis pathogenesis are not fully understood. However, recent in vivo and in vitro studies show that actin cytoskeletal reorganization plays a critical role in the progression of osteoarthritis. It has been shown that targeting the inhibition of actin-bundling protein, fascin, is a favorable way to reorganize actin and prevent chondrocyte dedifferentiation that occurs in osteoarthritis. In a surgical model of osteoarthritis, targeting fascin reduces cartilage degradation and disease severity. These findings highlight the therapeutic potential of targeting fascin in osteoarthritis. Future research to develop a further mechanistic understanding on the critical role actin and actin network molecules play in osteoarthritis may lead to the development of actin-based therapies against disease progression.

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