{"title":"凝血生物标志物对成人胶质母细胞瘤患者生存结局的影响。","authors":"Rahmi Atıl Aksoy, Timur Koca, Yasemin Şengün, Ece Atak, Aylin Fidan Korcum","doi":"10.3390/medicina61040756","DOIUrl":null,"url":null,"abstract":"<p><p><i>Background and Objectives</i>: Glioblastoma presents a significant challenge in oncology due to its aggressive nature and poor prognosis, despite advancements in treatment. This study aims to comprehensively evaluate the prognostic significance of coagulation biomarkers, including the novel albumin/D-dimer ratio, in adult glioblastoma patients. <i>Material and Methods</i>: This retrospective study included 74 adult glioblastoma patients who underwent Stupp protocol treatment. Blood samples were collected before radiotherapy to measure biomarkers, including prothrombin time (PT), activated partial thromboplastin time (aPTT), albumin, D-dimer, and the albumin/D-dimer ratio. The prognostic significance of these biomarkers for progression-free survival (PFS) and overall survival (OS) was assessed using both univariate and multivariate Cox regression analyses. <i>Results</i>: The median follow-up time was 12.2 months (range, 1-77.4 months). Univariate analysis revealed that ECOG performance status (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.03), and albumin (<i>p</i> = 0.001) were significant prognostic factors for PFS. Multivariate analysis identified albumin (<i>p</i> = 0.02) as an independent prognostic biomarker for PFS. For OS, univariate analysis showed that age (<i>p</i> = 0.004), ECOG performance status (<i>p</i> = 0.001), tumor volume (<i>p</i> = 0.007), extent of resection (<i>p</i> = 0.01), radiotherapy dose (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.02), albumin (<i>p</i> = 0.001), albumin/D-dimer ratio (<i>p</i> = 0.02), and PT (<i>p</i> = 0.002) were significant prognostic factors. Multivariate analysis revealed age (<i>p</i> = 0.04), extent of resection (<i>p</i> = 0.02), and PT (<i>p</i> = 0.04) as independent prognostic factors for OS. <i>Conclusions</i>: Our findings highlight the prognostic significance of coagulation biomarkers, particularly PT, D-dimer, albumin, and the albumin/D-dimer ratio, in glioblastoma. These biomarkers may serve as valuable tools for prognostic assessment and personalized treatment strategies, warranting further exploration in larger prospective studies.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029277/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma.\",\"authors\":\"Rahmi Atıl Aksoy, Timur Koca, Yasemin Şengün, Ece Atak, Aylin Fidan Korcum\",\"doi\":\"10.3390/medicina61040756\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Background and Objectives</i>: Glioblastoma presents a significant challenge in oncology due to its aggressive nature and poor prognosis, despite advancements in treatment. This study aims to comprehensively evaluate the prognostic significance of coagulation biomarkers, including the novel albumin/D-dimer ratio, in adult glioblastoma patients. <i>Material and Methods</i>: This retrospective study included 74 adult glioblastoma patients who underwent Stupp protocol treatment. Blood samples were collected before radiotherapy to measure biomarkers, including prothrombin time (PT), activated partial thromboplastin time (aPTT), albumin, D-dimer, and the albumin/D-dimer ratio. The prognostic significance of these biomarkers for progression-free survival (PFS) and overall survival (OS) was assessed using both univariate and multivariate Cox regression analyses. <i>Results</i>: The median follow-up time was 12.2 months (range, 1-77.4 months). Univariate analysis revealed that ECOG performance status (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.03), and albumin (<i>p</i> = 0.001) were significant prognostic factors for PFS. Multivariate analysis identified albumin (<i>p</i> = 0.02) as an independent prognostic biomarker for PFS. For OS, univariate analysis showed that age (<i>p</i> = 0.004), ECOG performance status (<i>p</i> = 0.001), tumor volume (<i>p</i> = 0.007), extent of resection (<i>p</i> = 0.01), radiotherapy dose (<i>p</i> = 0.001), D-dimer (<i>p</i> = 0.02), albumin (<i>p</i> = 0.001), albumin/D-dimer ratio (<i>p</i> = 0.02), and PT (<i>p</i> = 0.002) were significant prognostic factors. Multivariate analysis revealed age (<i>p</i> = 0.04), extent of resection (<i>p</i> = 0.02), and PT (<i>p</i> = 0.04) as independent prognostic factors for OS. <i>Conclusions</i>: Our findings highlight the prognostic significance of coagulation biomarkers, particularly PT, D-dimer, albumin, and the albumin/D-dimer ratio, in glioblastoma. These biomarkers may serve as valuable tools for prognostic assessment and personalized treatment strategies, warranting further exploration in larger prospective studies.</p>\",\"PeriodicalId\":49830,\"journal\":{\"name\":\"Medicina-Lithuania\",\"volume\":\"61 4\",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029277/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina-Lithuania\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/medicina61040756\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina-Lithuania","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/medicina61040756","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
The Impact of Coagulation Biomarkers on Survival Outcomes in Adult Glioblastoma.
Background and Objectives: Glioblastoma presents a significant challenge in oncology due to its aggressive nature and poor prognosis, despite advancements in treatment. This study aims to comprehensively evaluate the prognostic significance of coagulation biomarkers, including the novel albumin/D-dimer ratio, in adult glioblastoma patients. Material and Methods: This retrospective study included 74 adult glioblastoma patients who underwent Stupp protocol treatment. Blood samples were collected before radiotherapy to measure biomarkers, including prothrombin time (PT), activated partial thromboplastin time (aPTT), albumin, D-dimer, and the albumin/D-dimer ratio. The prognostic significance of these biomarkers for progression-free survival (PFS) and overall survival (OS) was assessed using both univariate and multivariate Cox regression analyses. Results: The median follow-up time was 12.2 months (range, 1-77.4 months). Univariate analysis revealed that ECOG performance status (p = 0.001), D-dimer (p = 0.03), and albumin (p = 0.001) were significant prognostic factors for PFS. Multivariate analysis identified albumin (p = 0.02) as an independent prognostic biomarker for PFS. For OS, univariate analysis showed that age (p = 0.004), ECOG performance status (p = 0.001), tumor volume (p = 0.007), extent of resection (p = 0.01), radiotherapy dose (p = 0.001), D-dimer (p = 0.02), albumin (p = 0.001), albumin/D-dimer ratio (p = 0.02), and PT (p = 0.002) were significant prognostic factors. Multivariate analysis revealed age (p = 0.04), extent of resection (p = 0.02), and PT (p = 0.04) as independent prognostic factors for OS. Conclusions: Our findings highlight the prognostic significance of coagulation biomarkers, particularly PT, D-dimer, albumin, and the albumin/D-dimer ratio, in glioblastoma. These biomarkers may serve as valuable tools for prognostic assessment and personalized treatment strategies, warranting further exploration in larger prospective studies.
期刊介绍：
The journal’s main focus is on reviews as well as clinical and experimental investigations. The journal aims to advance knowledge related to problems in medicine in developing countries as well as developed economies, to disseminate research on global health, and to promote and foster prevention and treatment of diseases worldwide. MEDICINA publications cater to clinicians, diagnosticians and researchers, and serve as a forum to discuss the current status of health-related matters and their impact on a global and local scale.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
