氙对系留脂质双分子层电压电流特性的影响。

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Membrane Biology Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI:10.1007/s00232-025-00346-3
Hadeel Alobeedallah, Bruce Cornell, Hans Coster
{"title":"氙对系留脂质双分子层电压电流特性的影响。","authors":"Hadeel Alobeedallah, Bruce Cornell, Hans Coster","doi":"10.1007/s00232-025-00346-3","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, we describe the effect of the noble gas, xenon on the electrical properties of tethered lipid bilayer membranes, (tBLMs), including the effect of xenon on the activation energy for electrical conduction through the tBLM. Such studies benefit from the stability of a tethered membrane given the wide range of temperatures that are scanned and the time required for these measurements. The results indicate that xenon increases the activation energy for electrical conduction through bilayers and decreases the average pore size that dominates the electrical conductance of the lipid bilayers at low voltages. Xenon possesses a high affinity for lipid membranes and is a potent general anaesthetic. Its anaesthetic potency is possibly associated with its effects on proteins embedded in the lipid membranes.</p>","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"213-224"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081542/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers.\",\"authors\":\"Hadeel Alobeedallah, Bruce Cornell, Hans Coster\",\"doi\":\"10.1007/s00232-025-00346-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this study, we describe the effect of the noble gas, xenon on the electrical properties of tethered lipid bilayer membranes, (tBLMs), including the effect of xenon on the activation energy for electrical conduction through the tBLM. Such studies benefit from the stability of a tethered membrane given the wide range of temperatures that are scanned and the time required for these measurements. The results indicate that xenon increases the activation energy for electrical conduction through bilayers and decreases the average pore size that dominates the electrical conductance of the lipid bilayers at low voltages. Xenon possesses a high affinity for lipid membranes and is a potent general anaesthetic. Its anaesthetic potency is possibly associated with its effects on proteins embedded in the lipid membranes.</p>\",\"PeriodicalId\":50129,\"journal\":{\"name\":\"Journal of Membrane Biology\",\"volume\":\" \",\"pages\":\"213-224\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081542/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Membrane Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s00232-025-00346-3\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Membrane Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00232-025-00346-3","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/28 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

在本研究中,我们描述了稀有气体氙对系系脂质双分子层膜(tBLMs)电学性能的影响,包括氙对通过tBLM的电传导活化能的影响。考虑到扫描的温度范围和测量所需的时间,这些研究得益于系绳膜的稳定性。结果表明,在低电压下,氙增加了脂质双分子层导电的活化能,减小了脂质双分子层导电的平均孔径。氙对脂质膜有很高的亲和力,是一种有效的全身麻醉剂。它的麻醉效力可能与它对嵌入脂质膜的蛋白质的作用有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers.

In this study, we describe the effect of the noble gas, xenon on the electrical properties of tethered lipid bilayer membranes, (tBLMs), including the effect of xenon on the activation energy for electrical conduction through the tBLM. Such studies benefit from the stability of a tethered membrane given the wide range of temperatures that are scanned and the time required for these measurements. The results indicate that xenon increases the activation energy for electrical conduction through bilayers and decreases the average pore size that dominates the electrical conductance of the lipid bilayers at low voltages. Xenon possesses a high affinity for lipid membranes and is a potent general anaesthetic. Its anaesthetic potency is possibly associated with its effects on proteins embedded in the lipid membranes.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Membrane Biology
Journal of Membrane Biology 生物-生化与分子生物学
CiteScore
4.80
自引率
4.20%
发文量
63
审稿时长
6-12 weeks
期刊介绍: The Journal of Membrane Biology is dedicated to publishing high-quality science related to membrane biology, biochemistry and biophysics. In particular, we welcome work that uses modern experimental or computational methods including but not limited to those with microscopy, diffraction, NMR, computer simulations, or biochemistry aimed at membrane associated or membrane embedded proteins or model membrane systems. These methods might be applied to study topics like membrane protein structure and function, membrane mediated or controlled signaling mechanisms, cell-cell communication via gap junctions, the behavior of proteins and lipids based on monolayer or bilayer systems, or genetic and regulatory mechanisms controlling membrane function. Research articles, short communications and reviews are all welcome. We also encourage authors to consider publishing ''negative'' results where experiments or simulations were well performed, but resulted in unusual or unexpected outcomes without obvious explanations. While we welcome connections to clinical studies, submissions that are primarily clinical in nature or that fail to make connections to the basic science issues of membrane structure, chemistry and function, are not appropriate for the journal. In a similar way, studies that are primarily descriptive and narratives of assays in a clinical or population study are best published in other journals. If you are not certain, it is entirely appropriate to write to us to inquire if your study is a good fit for the journal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信