发布求助
文献互助 智能选刊 最新文献

mRNA疫苗：基于mirna的可控生物分布和定向佐剂。

IF 13.1 1区 医学 Q1 IMMUNOLOGY
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI:10.1016/j.it.2025.03.004
Byron Brook, Morgan Goetz, Valerie Duval, Romain Micol, David J Dowling
{"title":"mRNA疫苗：基于mirna的可控生物分布和定向佐剂。","authors":"Byron Brook, Morgan Goetz, Valerie Duval, Romain Micol, David J Dowling","doi":"10.1016/j.it.2025.03.004","DOIUrl":null,"url":null,"abstract":"<p><p>The development of ionizable mRNA-lipid nanoparticle (mRNA-LNP) nucleic acid carriers facilitated the clinical translation of the Coronavirus 2019 (COVID-19) mRNA vaccines BNT162b2 and mRNA-1273. Here, we discuss insights into rational improvements to mRNA vaccines, focusing on LNP modifications for mRNA-LNP biodistribution control, miRNA-based biodistribution control of encoded transcripts, and precision adjuvantation strategies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"357-360"},"PeriodicalIF":13.1000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.\",\"authors\":\"Byron Brook, Morgan Goetz, Valerie Duval, Romain Micol, David J Dowling\",\"doi\":\"10.1016/j.it.2025.03.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The development of ionizable mRNA-lipid nanoparticle (mRNA-LNP) nucleic acid carriers facilitated the clinical translation of the Coronavirus 2019 (COVID-19) mRNA vaccines BNT162b2 and mRNA-1273. Here, we discuss insights into rational improvements to mRNA vaccines, focusing on LNP modifications for mRNA-LNP biodistribution control, miRNA-based biodistribution control of encoded transcripts, and precision adjuvantation strategies.</p>\",\"PeriodicalId\":54412,\"journal\":{\"name\":\"Trends in Immunology\",\"volume\":\"46 5\",\"pages\":\"357-360\"},\"PeriodicalIF\":13.1000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.it.2025.03.004\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.it.2025.03.004","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

可电离mRNA-脂质纳米颗粒（mRNA- lnp）核酸载体的开发促进了2019冠状病毒（COVID-19） mRNA疫苗BNT162b2和mRNA-1273的临床翻译。在这里，我们讨论了合理改进mRNA疫苗的见解，重点是LNP修饰mRNA-LNP生物分布控制，基于mirna的编码转录物生物分布控制以及精确调节策略。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
分享
查看原文 本刊更多论文
mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.

The development of ionizable mRNA-lipid nanoparticle (mRNA-LNP) nucleic acid carriers facilitated the clinical translation of the Coronavirus 2019 (COVID-19) mRNA vaccines BNT162b2 and mRNA-1273. Here, we discuss insights into rational improvements to mRNA vaccines, focusing on LNP modifications for mRNA-LNP biodistribution control, miRNA-based biodistribution control of encoded transcripts, and precision adjuvantation strategies.

求助全文
通过发布文献求助，成功后即可免费获取论文全文。 去求助
来源期刊
Trends in Immunology
Trends in Immunology 医学-免疫学
CiteScore
25.10
自引率
0.60%
发文量
130
审稿时长
6-12 weeks
期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信