PERMA-based psychological intervention in glioma rehabilitation: An RCT on affective distress, treatment adherence, and neuro-oncological outcomes.

ObjectivePostoperative glioma patients often experience negative emotions, affecting their treatment adherence and prognosis. The PERMA intervention (focusing on Positive emotions, Engagement, Relationship, Meaning, and Accomplishment) seeks to enhance psychological well-being and quality of life (QoL). This study examines its effects on negative emotions, treatment adherence, and prognosis in postoperative glioma patients.MethodsA total of 124 postoperative glioma patients from January 2022 to February 2024 were randomly assigned to an intervention group (n = 62) or a control group (n = 62). The control group received routine postoperative care, while the intervention group received additional PERMA psychological intervention for 1 month. Assessments included anxiety symptoms (SAS), depressive symptoms (SDS), treatment adherence, complications, and QoL. Prognosis was analyzed using Kaplan-Meier (KM) survival curves.ResultsBaseline characteristics were comparable between groups (P > 0.05). After intervention, both groups showed significant improvements in SAS and SDS scores (P < 0.05), furthermore, post-intervention SAS and SDS scores in the intervention group were significantly lower than those in the control group (P < 0.0001). Treatment adherence was significantly higher, and complication rates were lower in the intervention group compared to control group (P < 0.05). QoL was improved in both groups (P < 0.05), notably, post-intervention, the intervention group scored significantly higher than control group across all QoL domains (P < 0.0001). KM analysis revealed a significant association between the PERMA-based intervention and better prognosis (P < 0.05).ConclusionPERMA-based psychological intervention effectively reduces anxiety and depression, enhances treatment adherence, lowers complication risks, and improves QoL in postoperative glioma patients.