多维多基因睡眠健康评分和睡眠生活方式指数与疾病结局的关联及其在临床生物库中的相互作用

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Sleep Health Pub Date : 2025-06-01 DOI:10.1016/j.sleh.2025.02.009

Valentina Paz MSc , Hannah Wilcox BSc , Matthew Goodman PhD , Heming Wang PhD , Victoria Garfield PhD , Richa Saxena PhD , Hassan S. Dashti PhD

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引用次数: 0

摘要

目的：睡眠是一种复杂的行为，受影响疾病结局的遗传和环境因素的调节。然而，包含多个睡眠维度的多维睡眠对常见疾病，特别是精神健康障碍的影响尚未得到充分阐明。利用麻省总医院布里格姆生物银行，我们检查了多维睡眠与疾病结果的关联，并调查了睡眠行为是否调节了不利睡眠对心理健康疾病的遗传易感。方法：我们使用先前确定的单核苷酸多态性生成了多基因睡眠健康评分，并基于自我报告的问题和电子健康记录构建了睡眠生活方式指数；测试他们的联系；在这些指标与临床表型之间进行全现象相关性分析；并分析其与流行心理疾病的相互作用。共有15884名参与者被纳入分析(平均年龄54.4岁；58.6%的女性)。结果：多基因睡眠健康评分与睡眠生活方式指数相关（β=0.050, 95% CI=0.032, 0.068），并与12种疾病组的114种疾病结局相关，包括肥胖、睡眠和物质使用疾病结局（p-5）。睡眠生活方式指数与17组458种疾病结果相关，包括睡眠、情绪和焦虑疾病结果（p-5）。共有108种疾病结局与这两个指标相关，涵盖12个疾病组。心理健康疾病指标间无交互作用。结论：良好的睡眠行为和健康睡眠的遗传倾向可能独立地预防疾病，强调多维睡眠对人群健康的影响以及关注健康睡眠习惯的预防策略的必要性。

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Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank

Objectives

Sleep is a complex behavior regulated by genetic and environmental factors impacting disease outcomes. However, the effect of multidimensional sleep encompassing several sleep dimensions on common diseases, specifically mental health disorders, has yet to be fully elucidated. Using the Mass General Brigham Biobank, we examined the association of multidimensional sleep with disease outcomes and investigated whether sleep behaviors modulate genetic predisposition to unfavorable sleep on mental health diseases.

Methods

We generated a Polygenic Sleep Health Score using previously identified single nucleotide polymorphisms and constructed a Sleep Lifestyle Index based on self-reported questions and electronic health records; tested their association; performed phenome-wide association analyses between these indexes and clinical phenotypes; and analyzed their interaction on prevalent mental health diseases. A total of 15,884 participants were included in the analysis (mean age 54.4; 58.6% female).

Results

The Polygenic Sleep Health Score was associated with the Sleep Lifestyle Index (β = 0.050, 95% CI = 0.032, 0.068) and with 114 disease outcomes spanning 12 disease groups, including obesity, sleep, and substance use disease outcomes (p < 3.3 × 10⁻⁵). The Sleep Lifestyle Index was associated with 458 disease outcomes spanning 17 groups, including sleep, mood, and anxiety disease outcomes (p < 5.1 × 10⁻⁵). A total of 108 disease outcomes were associated with both indexes, spanning 12 disease groups. No interactions were found between the indexes on mental health diseases.

Conclusions

Favorable sleep behaviors and genetic predisposition to healthy sleep may independently protect against disease, underscoring the impact of multidimensional sleep on population health and the need for prevention strategies focused on healthy sleep habits.

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来源期刊

Sleep Health CLINICAL NEUROLOGY-

CiteScore

6.30

自引率

9.80%

发文量

114

审稿时长

54 days

期刊介绍： Sleep Health Journal of the National Sleep Foundation is a multidisciplinary journal that explores sleep''s role in population health and elucidates the social science perspective on sleep and health. Aligned with the National Sleep Foundation''s global authoritative, evidence-based voice for sleep health, the journal serves as the foremost publication for manuscripts that advance the sleep health of all members of society.The scope of the journal extends across diverse sleep-related fields, including anthropology, education, health services research, human development, international health, law, mental health, nursing, nutrition, psychology, public health, public policy, fatigue management, transportation, social work, and sociology. The journal welcomes original research articles, review articles, brief reports, special articles, letters to the editor, editorials, and commentaries.