Ngoc-Niem Bui, Shih-Chiang Huang, Thi Nhu Le Tran, Ngoc Hien Nguyen, Hang Nga Do, Ya-Fang Chiu, Chih-Ho Lai
{"title":"幽门螺杆菌和eb病毒合并感染与胃癌风险的关系：一项系统综述和荟萃分析","authors":"Ngoc-Niem Bui, Shih-Chiang Huang, Thi Nhu Le Tran, Ngoc Hien Nguyen, Hang Nga Do, Ya-Fang Chiu, Chih-Ho Lai","doi":"10.1093/qjmed/hcaf092","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Co-infection with Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) has been demonstrated in clinical studies; however, its association with gastric cancer (GC) remains uncertain.</p><p><strong>Aims: </strong>This study aims to assess and establish evidence linking H. pylori and EBV co-infection to an increased risk of GC development.</p><p><strong>Methods: </strong>We conducted a meta-analysis study to investigate the pooled odds ratios (OR) for individual infections and co-infections, and their association with the risk of GC development.</p><p><strong>Results: </strong>EBV infection was more frequent in patients with GC than in non-GC patients (OR 4.98, 95% confidence interval (CI) 3.17-7.85, p < 0.0001). H. pylori infection was associated with a significantly increased GC risk compared with a control group excluding gastritis cases (OR 1.42, 95% CI 1.02-1.99, p = 0.03). Nevertheless, the random-effects model revealed that the pooled odds of co-infection were significantly elevated (OR 2.57, 95% CI 1.65-4.01, p < 0.0001).</p><p><strong>Conclusions: </strong>Both H. pylori and EBV infections increase the risk of developing GC. The co-infection of H. pylori and EBV was linked to a 2.57-fold higher risk of GC, indicating the significance of incorporating both infections into diagnostic and treatment approaches for GC.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Helicobacter pylori and Epstein-Barr virus co-infection and gastric cancer risk: A systematic review and meta-analysis.\",\"authors\":\"Ngoc-Niem Bui, Shih-Chiang Huang, Thi Nhu Le Tran, Ngoc Hien Nguyen, Hang Nga Do, Ya-Fang Chiu, Chih-Ho Lai\",\"doi\":\"10.1093/qjmed/hcaf092\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Co-infection with Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) has been demonstrated in clinical studies; however, its association with gastric cancer (GC) remains uncertain.</p><p><strong>Aims: </strong>This study aims to assess and establish evidence linking H. pylori and EBV co-infection to an increased risk of GC development.</p><p><strong>Methods: </strong>We conducted a meta-analysis study to investigate the pooled odds ratios (OR) for individual infections and co-infections, and their association with the risk of GC development.</p><p><strong>Results: </strong>EBV infection was more frequent in patients with GC than in non-GC patients (OR 4.98, 95% confidence interval (CI) 3.17-7.85, p < 0.0001). H. pylori infection was associated with a significantly increased GC risk compared with a control group excluding gastritis cases (OR 1.42, 95% CI 1.02-1.99, p = 0.03). Nevertheless, the random-effects model revealed that the pooled odds of co-infection were significantly elevated (OR 2.57, 95% CI 1.65-4.01, p < 0.0001).</p><p><strong>Conclusions: </strong>Both H. pylori and EBV infections increase the risk of developing GC. The co-infection of H. pylori and EBV was linked to a 2.57-fold higher risk of GC, indicating the significance of incorporating both infections into diagnostic and treatment approaches for GC.</p>\",\"PeriodicalId\":20806,\"journal\":{\"name\":\"QJM: An International Journal of Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"QJM: An International Journal of Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/qjmed/hcaf092\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"QJM: An International Journal of Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/qjmed/hcaf092","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Association between Helicobacter pylori and Epstein-Barr virus co-infection and gastric cancer risk: A systematic review and meta-analysis.
Background: Co-infection with Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) has been demonstrated in clinical studies; however, its association with gastric cancer (GC) remains uncertain.
Aims: This study aims to assess and establish evidence linking H. pylori and EBV co-infection to an increased risk of GC development.
Methods: We conducted a meta-analysis study to investigate the pooled odds ratios (OR) for individual infections and co-infections, and their association with the risk of GC development.
Results: EBV infection was more frequent in patients with GC than in non-GC patients (OR 4.98, 95% confidence interval (CI) 3.17-7.85, p < 0.0001). H. pylori infection was associated with a significantly increased GC risk compared with a control group excluding gastritis cases (OR 1.42, 95% CI 1.02-1.99, p = 0.03). Nevertheless, the random-effects model revealed that the pooled odds of co-infection were significantly elevated (OR 2.57, 95% CI 1.65-4.01, p < 0.0001).
Conclusions: Both H. pylori and EBV infections increase the risk of developing GC. The co-infection of H. pylori and EBV was linked to a 2.57-fold higher risk of GC, indicating the significance of incorporating both infections into diagnostic and treatment approaches for GC.
期刊介绍：
QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles.
Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence.
In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.
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