甲状腺舌管囊肿癌的回顾性研究及文献系统回顾。

IF 3.1 3区 医学 Q1 PATHOLOGY
Virchows Archiv Pub Date : 2025-06-01 Epub Date: 2025-05-10 DOI:10.1007/s00428-025-04125-2
Vivian Thimsen, Sarina Katrin Müller, Abbas Agaimy, Konstantinos Mantsopoulos, Michael Beck, Michael Koch, Heinrich Iro, Matti Sievert
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引用次数: 0

摘要

本研究的目的是通过单中心回顾性分析分析甲状腺舌管囊肿癌(TDCC),并辅以系统的文献综述以提供治疗方法。分析了2002年至2023年间三级转诊中心诊断为TDCC的患者记录。系统评价遵循PRISMA指南,包括Medline和PubMed的研究。提取患者资料,包括人口统计学、影像学结果和组织学结果。评估的主要结局是无肿瘤和无复发生存,而其他变量包括治疗方案和随访数据。分析共发现484例TDCC,确认甲状腺乳头状癌(PTC)为主要类型(94.2%),同步甲状腺癌占34.6%。年龄范围8 ~ 76岁,中位年龄40岁。女性有62%,男性有36%。复发率为7.4%,远处转移率为1%。无论采用何种治疗方案,总生存率为99.1%。虽然罕见,但TDCC主要表现为PTC,预后良好。Sistrunk手术仍然是主要的手术方法,但对于甲状腺全切除术、颈部清扫或放射性碘消融等治疗方法的最佳管理需要仔细评估危险因素,如罕见肿瘤类型、可疑淋巴结、甲状腺结节、年龄、辐射暴露和分子模式。强调更个性化的治疗策略,我们提出了一个算法,可以帮助减少侵入性和过度治疗的风险在选定的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thyroglossal duct cyst carcinomas - a retrospective study and systematic review of the literature.

The aim of this study was to analyze thyroglossal duct cyst carcinoma (TDCC) in a single-center retrospective analysis, supplemented by a systematic literature review to inform treatment approaches. Patient records from a tertiary referral center were analyzed for individuals diagnosed with TDCC between 2002 and 2023. A systematic review followed the PRISMA guidelines, encompassing studies from Medline and PubMed. Patient data, including demographics, imaging results, and histological findings were extracted. The primary outcome assessed was tumor-free and recurrence-free survival, while additional variables included treatment regimens and follow-up data. The analysis identified a total of 484 TDCC cases, confirming papillary thyroid carcinoma (PTC) as the predominant type (94.2%), with synchronous thyroid gland carcinomas observed in 34.6%. The age range was 8 to 76 with median age of 40 years. Women were affected in 62%, men in 36%. The recurrence rate was 7.4%, with distant metastases observed in 1% of cases. The overall survival rate was 99.1%, regardless of the treatment regimen. Although rare, TDCC predominantly presents as PTC, with a favorable prognosis. Sistrunk's procedure remains the primary surgical approach, but optimal management regarding therapies such as total thyroidectomy, neck dissection, or radioiodine ablation requires careful evaluation of risk factors like rare tumor types, suspicious lymph nodes, thyroid nodules, age, radiation exposure, and molecular patterns. Emphasizing more individualized treatment strategies, we propose an algorithm that can help to reduce invasiveness and overtreatment risks in selected cases.

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来源期刊
Virchows Archiv
Virchows Archiv 医学-病理学
CiteScore
7.40
自引率
2.90%
发文量
204
审稿时长
4-8 weeks
期刊介绍: Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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