{"title":"补锌联合肠道锌吸收促进剂二果糖对难治性味觉障碍患者血清锌浓度和血管紧张素转换酶载脂蛋白/全酶活性比值的影响","authors":"Noriaki Takeda, Tsukasa Takaoka, Ichiko Takemoto, Aki Endo, Rie Tsutsumi, Hiroshi Sakaue, Yoshiaki Kitamura","doi":"10.2152/jmi.72.156","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>ACE ratio in the serum is a more sensitive indicator of zinc nutrition than serum zinc concentration. In this study, we examined the effects of zinc supplementation in combination with difructose anhydride (DFA) that enhances zinc absorption in the intestine on serum zinc concentration and ACE ratio in patients with refractory taste impairment.</p><p><strong>Methods: </strong>Twenty patients with refractory taste impairment were enrolled. The patients received 34 mg of zinc in combination with 2.0 g of DFA orally every day for three months. Taste impairment was evaluated using visual analogue scale (VAS).</p><p><strong>Results: </strong>After zinc supplementation with DFA (zinc with DFA), ACE ratio was significantly decreased, but serum zinc concentration was not increased in patiens with refractory taste impairment. Although VAS score was not changed in the patients after zinc with DFA, we divided the patients into two groups : 14 responders and 6 non-responders. ACE ratio in responders, but not in non-responders was significantly decreased after zinc with DFA. However, serum zinc concentration was not changed in both responders and non-responders after zinc with DFA.</p><p><strong>Conclusion: </strong>The present findings suggest that malabsorption of zinc in the intestine is the primary cause of zinc deficiency in patients with refractory taste impairment. J. Med. Invest. 72 : 156-160, February, 2025.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"72 1.2","pages":"156-160"},"PeriodicalIF":0.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of zinc supplementation in combination with difructose, an enhancer of intestinal zinc absorption, on serum zinc concentration and ratio of apo-/holo-activities of angiotensin-converting enzyme in patients with refractory taste impairment.\",\"authors\":\"Noriaki Takeda, Tsukasa Takaoka, Ichiko Takemoto, Aki Endo, Rie Tsutsumi, Hiroshi Sakaue, Yoshiaki Kitamura\",\"doi\":\"10.2152/jmi.72.156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>ACE ratio in the serum is a more sensitive indicator of zinc nutrition than serum zinc concentration. In this study, we examined the effects of zinc supplementation in combination with difructose anhydride (DFA) that enhances zinc absorption in the intestine on serum zinc concentration and ACE ratio in patients with refractory taste impairment.</p><p><strong>Methods: </strong>Twenty patients with refractory taste impairment were enrolled. The patients received 34 mg of zinc in combination with 2.0 g of DFA orally every day for three months. Taste impairment was evaluated using visual analogue scale (VAS).</p><p><strong>Results: </strong>After zinc supplementation with DFA (zinc with DFA), ACE ratio was significantly decreased, but serum zinc concentration was not increased in patiens with refractory taste impairment. Although VAS score was not changed in the patients after zinc with DFA, we divided the patients into two groups : 14 responders and 6 non-responders. ACE ratio in responders, but not in non-responders was significantly decreased after zinc with DFA. However, serum zinc concentration was not changed in both responders and non-responders after zinc with DFA.</p><p><strong>Conclusion: </strong>The present findings suggest that malabsorption of zinc in the intestine is the primary cause of zinc deficiency in patients with refractory taste impairment. J. Med. Invest. 72 : 156-160, February, 2025.</p>\",\"PeriodicalId\":46910,\"journal\":{\"name\":\"JOURNAL OF MEDICAL INVESTIGATION\",\"volume\":\"72 1.2\",\"pages\":\"156-160\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOURNAL OF MEDICAL INVESTIGATION\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2152/jmi.72.156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF MEDICAL INVESTIGATION","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2152/jmi.72.156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
目的：血清ACE比血清锌浓度更能反映锌营养状况。在这项研究中，我们研究了锌补充剂联合双果糖酸酐（DFA）对难治性味觉障碍患者血清锌浓度和ACE比率的影响。方法：选取20例难治性味觉障碍患者。患者每天口服34 mg锌和2.0 g DFA，持续3个月。用视觉模拟量表（VAS）评价味觉损伤。结果：难治性味觉障碍患者补充DFA锌后，ACE比值明显降低，血清锌浓度未升高。虽然锌加DFA后患者的VAS评分没有改变，但我们将患者分为两组：14例有反应者和6例无反应者。服用DFA后，反应者的ACE比率显著降低，而无反应者的ACE比率则无显著降低。然而，服用DFA后，有反应者和无反应者的血清锌浓度没有变化。结论：小肠对锌的吸收不良是难治性味觉障碍患者缺锌的主要原因。中华医学杂志，2015,32(2):559 - 561。
Effects of zinc supplementation in combination with difructose, an enhancer of intestinal zinc absorption, on serum zinc concentration and ratio of apo-/holo-activities of angiotensin-converting enzyme in patients with refractory taste impairment.
Objective: ACE ratio in the serum is a more sensitive indicator of zinc nutrition than serum zinc concentration. In this study, we examined the effects of zinc supplementation in combination with difructose anhydride (DFA) that enhances zinc absorption in the intestine on serum zinc concentration and ACE ratio in patients with refractory taste impairment.
Methods: Twenty patients with refractory taste impairment were enrolled. The patients received 34 mg of zinc in combination with 2.0 g of DFA orally every day for three months. Taste impairment was evaluated using visual analogue scale (VAS).
Results: After zinc supplementation with DFA (zinc with DFA), ACE ratio was significantly decreased, but serum zinc concentration was not increased in patiens with refractory taste impairment. Although VAS score was not changed in the patients after zinc with DFA, we divided the patients into two groups : 14 responders and 6 non-responders. ACE ratio in responders, but not in non-responders was significantly decreased after zinc with DFA. However, serum zinc concentration was not changed in both responders and non-responders after zinc with DFA.
Conclusion: The present findings suggest that malabsorption of zinc in the intestine is the primary cause of zinc deficiency in patients with refractory taste impairment. J. Med. Invest. 72 : 156-160, February, 2025.
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