{"title":"关节周围注射在全膝关节置换术后疼痛中的作用。","authors":"E Carlos Rodriguez-Merchan","doi":"10.22038/ABJS.2024.82135.3736","DOIUrl":null,"url":null,"abstract":"<p><p>Periarticular multimodal drug injection (PMDI) is better than FNB (femoral nerve block) in pain relief after total knee arthroplasty (TKA). PMDI of bupivacaine [20 mL 0.5% bupivacaine hydrochloride - HCl (100 mg) following implantation plus incisional injection of 10 mL 0.5% bupivacaine HCl (50 mg) before wound closure] is more efficacious than PMDI after implantation. PMDI leads to less postoperative pain than IAI (intraarticular injection) and IAI + PMDI. PMDI of magnesium sulfate and sodium bicarbonate added to a conventional PMDI (ropivacaine, epinephrine, and dexamethasone) prolongs analgesia. No differences exist between gonyautoxin (GTX)2/3 (40 µg GTX 2/3 diluted in 30 mL of sodium chloride 0.9%) and a combination of 300 mg of levobupivacaine, 1 mg of epinephrine, and 60 mg ketorolac diluted in 150 mL of sodium chloride 0.9%.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"13 4","pages":"229-232"},"PeriodicalIF":1.2000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050083/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of Periarticular Injections for Postoperative Pain after Total Knee Arthroplasty.\",\"authors\":\"E Carlos Rodriguez-Merchan\",\"doi\":\"10.22038/ABJS.2024.82135.3736\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Periarticular multimodal drug injection (PMDI) is better than FNB (femoral nerve block) in pain relief after total knee arthroplasty (TKA). PMDI of bupivacaine [20 mL 0.5% bupivacaine hydrochloride - HCl (100 mg) following implantation plus incisional injection of 10 mL 0.5% bupivacaine HCl (50 mg) before wound closure] is more efficacious than PMDI after implantation. PMDI leads to less postoperative pain than IAI (intraarticular injection) and IAI + PMDI. PMDI of magnesium sulfate and sodium bicarbonate added to a conventional PMDI (ropivacaine, epinephrine, and dexamethasone) prolongs analgesia. No differences exist between gonyautoxin (GTX)2/3 (40 µg GTX 2/3 diluted in 30 mL of sodium chloride 0.9%) and a combination of 300 mg of levobupivacaine, 1 mg of epinephrine, and 60 mg ketorolac diluted in 150 mL of sodium chloride 0.9%.</p>\",\"PeriodicalId\":46704,\"journal\":{\"name\":\"Archives of Bone and Joint Surgery-ABJS\",\"volume\":\"13 4\",\"pages\":\"229-232\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050083/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Bone and Joint Surgery-ABJS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/ABJS.2024.82135.3736\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Bone and Joint Surgery-ABJS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/ABJS.2024.82135.3736","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
The Role of Periarticular Injections for Postoperative Pain after Total Knee Arthroplasty.
Periarticular multimodal drug injection (PMDI) is better than FNB (femoral nerve block) in pain relief after total knee arthroplasty (TKA). PMDI of bupivacaine [20 mL 0.5% bupivacaine hydrochloride - HCl (100 mg) following implantation plus incisional injection of 10 mL 0.5% bupivacaine HCl (50 mg) before wound closure] is more efficacious than PMDI after implantation. PMDI leads to less postoperative pain than IAI (intraarticular injection) and IAI + PMDI. PMDI of magnesium sulfate and sodium bicarbonate added to a conventional PMDI (ropivacaine, epinephrine, and dexamethasone) prolongs analgesia. No differences exist between gonyautoxin (GTX)2/3 (40 µg GTX 2/3 diluted in 30 mL of sodium chloride 0.9%) and a combination of 300 mg of levobupivacaine, 1 mg of epinephrine, and 60 mg ketorolac diluted in 150 mL of sodium chloride 0.9%.
期刊介绍：
The Archives of Bone and Joint Surgery (ABJS) aims to encourage a better understanding of all aspects of Orthopedic Sciences. The journal accepts scientific papers including original research, review article, short communication, case report, and letter to the editor in all fields of bone, joint, musculoskeletal surgery and related researches. The Archives of Bone and Joint Surgery (ABJS) will publish papers in all aspects of today`s modern orthopedic sciences including: Arthroscopy, Arthroplasty, Sport Medicine, Reconstruction, Hand and Upper Extremity, Pediatric Orthopedics, Spine, Trauma, Foot and Ankle, Tumor, Joint Rheumatic Disease, Skeletal Imaging, Orthopedic Physical Therapy, Rehabilitation, Orthopedic Basic Sciences (Biomechanics, Biotechnology, Biomaterial..).
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