{"title":"血液系统恶性肿瘤患者刚地弓形虫抗体血清阳性率分析。","authors":"Y Yang, Q Wang, L Xiang, Y Meng, C Zhang, J Fu","doi":"10.16250/j.32.1915.2025044","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the seroprevalence of antibody against <i>Toxoplasma gondii</i> among patients with hematological malignancies, and compare it with that among health individuals, so as to provide insights into unraveling the pathogenesis of hematological malignancies.</p><p><strong>Methods: </strong>A total of 225 patients with hematological malignancies in Department of Hematology, Xuzhou Central Hospital and 300 healthy individuals in the same hospital were enrolled from 2017 to 2024. Blood samples were collected from all subjects, and the serum IgG and IgM antibodies against <i>T. gondii</i> were detected using chemiluminescent immunoassay. Demographic and clinical features were collected from patients with hematological malignancies, including gender, age, contact with cats, consumption of raw or undercooked meat, type of malignancy, clinical symptoms, blood transfusion and treatment, and the seroprevalence of anti-<i>T. gondii</i> antibody was compared among patients with different characteristics.</p><p><strong>Results: </strong>The age (<i>t</i> = 0.72, <i>P</i> > 0.05) and gender (χ<sup>2</sup> = 0.93, <i>P</i> > 0.05) were compared between patients with hematological malignancies and healthy individuals. The seroprevalence of <i>T. gondii</i> infection was 20.89% among patients with hematological malignancies and 4.33% among healthy individuals (χ<sup>2</sup> = 34.81, <i>P</i> < 0.01), and the seroprevalence of anti-<i>T. gondii</i> IgG antibody was 20.89% among patients with hematological malignancies and 4.33% among healthy individuals (χ<sup>2</sup> = 34.81, <i>P</i> < 0.01), while there was no significant difference in the seroprevalence of anti-<i>T. gondii</i> IgM antibody between patients with hematological malignancies and healthy individuals (1.33% vs. 0; corrected χ<sup>2</sup> = 2.02, <i>P</i> > 0.05). The seroprevalence of <i>T. gondii</i> infection was 23.08% among patients with leukemia, 16.67% among patients with lymphoma, 19.23% among patients with multiple myeloma, 24.00% among patients with myeloproliferative neoplasm, and 26.09% among patients with myelodysplastic syndrome (χ<sup>2</sup> = 1.44, <i>P</i> > 0.05), and was all higher than among healthy individuals (corrected χ<sup>2</sup> = 23.92, 10.74, 13.76, 12.84 and 14.54; all <i>P</i> values < 0.01). In addition, there were no significant differences in the detection of anti-<i>T. gondii</i> antibody among patients with hematological malignancies in terms of gender, age, contact with cats, consumption of raw or undercooked meat, chemotherapy or blood transfusion (χ<sup>2</sup> = 0.76, 1.97, 0, 2.81, 2.38 and 0.66; all <i>P</i> values > 0.05).</p><p><strong>Conclusions: </strong>There is a high risk of <i>T. gondii</i> infection among patients with hematological malignancies, and intensified surveillance of <i>T. gondii</i> infection is recommended among patients with hematological malignancies.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 1","pages":"93-97"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Seroprevalence of antibody against <i>Toxoplasma gondii</i> among patients with hematological malignancies].\",\"authors\":\"Y Yang, Q Wang, L Xiang, Y Meng, C Zhang, J Fu\",\"doi\":\"10.16250/j.32.1915.2025044\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the seroprevalence of antibody against <i>Toxoplasma gondii</i> among patients with hematological malignancies, and compare it with that among health individuals, so as to provide insights into unraveling the pathogenesis of hematological malignancies.</p><p><strong>Methods: </strong>A total of 225 patients with hematological malignancies in Department of Hematology, Xuzhou Central Hospital and 300 healthy individuals in the same hospital were enrolled from 2017 to 2024. Blood samples were collected from all subjects, and the serum IgG and IgM antibodies against <i>T. gondii</i> were detected using chemiluminescent immunoassay. Demographic and clinical features were collected from patients with hematological malignancies, including gender, age, contact with cats, consumption of raw or undercooked meat, type of malignancy, clinical symptoms, blood transfusion and treatment, and the seroprevalence of anti-<i>T. gondii</i> antibody was compared among patients with different characteristics.</p><p><strong>Results: </strong>The age (<i>t</i> = 0.72, <i>P</i> > 0.05) and gender (χ<sup>2</sup> = 0.93, <i>P</i> > 0.05) were compared between patients with hematological malignancies and healthy individuals. The seroprevalence of <i>T. gondii</i> infection was 20.89% among patients with hematological malignancies and 4.33% among healthy individuals (χ<sup>2</sup> = 34.81, <i>P</i> < 0.01), and the seroprevalence of anti-<i>T. gondii</i> IgG antibody was 20.89% among patients with hematological malignancies and 4.33% among healthy individuals (χ<sup>2</sup> = 34.81, <i>P</i> < 0.01), while there was no significant difference in the seroprevalence of anti-<i>T. gondii</i> IgM antibody between patients with hematological malignancies and healthy individuals (1.33% vs. 0; corrected χ<sup>2</sup> = 2.02, <i>P</i> > 0.05). The seroprevalence of <i>T. gondii</i> infection was 23.08% among patients with leukemia, 16.67% among patients with lymphoma, 19.23% among patients with multiple myeloma, 24.00% among patients with myeloproliferative neoplasm, and 26.09% among patients with myelodysplastic syndrome (χ<sup>2</sup> = 1.44, <i>P</i> > 0.05), and was all higher than among healthy individuals (corrected χ<sup>2</sup> = 23.92, 10.74, 13.76, 12.84 and 14.54; all <i>P</i> values < 0.01). In addition, there were no significant differences in the detection of anti-<i>T. gondii</i> antibody among patients with hematological malignancies in terms of gender, age, contact with cats, consumption of raw or undercooked meat, chemotherapy or blood transfusion (χ<sup>2</sup> = 0.76, 1.97, 0, 2.81, 2.38 and 0.66; all <i>P</i> values > 0.05).</p><p><strong>Conclusions: </strong>There is a high risk of <i>T. gondii</i> infection among patients with hematological malignancies, and intensified surveillance of <i>T. gondii</i> infection is recommended among patients with hematological malignancies.</p>\",\"PeriodicalId\":38874,\"journal\":{\"name\":\"中国血吸虫病防治杂志\",\"volume\":\"37 1\",\"pages\":\"93-97\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国血吸虫病防治杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.16250/j.32.1915.2025044\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国血吸虫病防治杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.16250/j.32.1915.2025044","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的:了解恶性血液病患者血清刚地弓形虫抗体的阳性率,并与健康人群进行比较,为揭示恶性血液病的发病机制提供依据。方法:选取2017 - 2024年徐州市中心医院血液科恶性血液病患者225例和该医院健康人群300例。采集所有受试者血样,采用化学发光免疫法检测血清中抗弓形虫IgG和IgM抗体。收集血液学恶性肿瘤患者的人口统计学和临床特征,包括性别、年龄、与猫的接触、食用生肉或未煮熟的肉、恶性肿瘤类型、临床症状、输血和治疗,以及抗t抗体的血清阳性率。比较不同特征患者的弓形虫抗体。结果:血液病患者与健康人的年龄(t = 0.72, P < 0.05)、性别(χ2 = 0.93, P < 0.05)差异有统计学意义。血液系统恶性肿瘤患者弓形虫感染的血清阳性率为20.89%,健康人群为4.33% (χ2 = 34.81, P < 0.01);恶性血液病患者弓形虫IgG抗体阳性率为20.89%,健康人为4.33% (χ2 = 34.81, P < 0.01),血清抗t抗体阳性率差异无统计学意义。恶性血液病患者与健康人群间弓形虫IgM抗体阳性率(1.33% vs. 0;χ2 = 2.02, P < 0.05)。血清弓形虫感染阳性率在白血病、淋巴瘤、多发性骨髓瘤、骨髓增生性肿瘤和骨髓增生异常综合征患者中分别为23.08%、16.67%、19.23%、24.00%和26.09% (χ2 = 1.44, P < 0.05),均高于健康人群(χ2校正后分别为23.92、10.74、13.76、12.84、14.54;P值均< 0.01)。此外,两组在抗t抗体检测上也无显著差异。恶性血液病患者的性别、年龄、与猫接触、食用生肉或未煮熟的肉、化疗或输血的弓形虫抗体水平(χ2 = 0.76、1.97、0、2.81、2.38、0.66;P值均为> 0.05)。结论:血液系统恶性肿瘤患者中弓形虫感染的风险较高,建议加强对血液系统恶性肿瘤患者弓形虫感染的监测。
[Seroprevalence of antibody against Toxoplasma gondii among patients with hematological malignancies].
Objective: To investigate the seroprevalence of antibody against Toxoplasma gondii among patients with hematological malignancies, and compare it with that among health individuals, so as to provide insights into unraveling the pathogenesis of hematological malignancies.
Methods: A total of 225 patients with hematological malignancies in Department of Hematology, Xuzhou Central Hospital and 300 healthy individuals in the same hospital were enrolled from 2017 to 2024. Blood samples were collected from all subjects, and the serum IgG and IgM antibodies against T. gondii were detected using chemiluminescent immunoassay. Demographic and clinical features were collected from patients with hematological malignancies, including gender, age, contact with cats, consumption of raw or undercooked meat, type of malignancy, clinical symptoms, blood transfusion and treatment, and the seroprevalence of anti-T. gondii antibody was compared among patients with different characteristics.
Results: The age (t = 0.72, P > 0.05) and gender (χ2 = 0.93, P > 0.05) were compared between patients with hematological malignancies and healthy individuals. The seroprevalence of T. gondii infection was 20.89% among patients with hematological malignancies and 4.33% among healthy individuals (χ2 = 34.81, P < 0.01), and the seroprevalence of anti-T. gondii IgG antibody was 20.89% among patients with hematological malignancies and 4.33% among healthy individuals (χ2 = 34.81, P < 0.01), while there was no significant difference in the seroprevalence of anti-T. gondii IgM antibody between patients with hematological malignancies and healthy individuals (1.33% vs. 0; corrected χ2 = 2.02, P > 0.05). The seroprevalence of T. gondii infection was 23.08% among patients with leukemia, 16.67% among patients with lymphoma, 19.23% among patients with multiple myeloma, 24.00% among patients with myeloproliferative neoplasm, and 26.09% among patients with myelodysplastic syndrome (χ2 = 1.44, P > 0.05), and was all higher than among healthy individuals (corrected χ2 = 23.92, 10.74, 13.76, 12.84 and 14.54; all P values < 0.01). In addition, there were no significant differences in the detection of anti-T. gondii antibody among patients with hematological malignancies in terms of gender, age, contact with cats, consumption of raw or undercooked meat, chemotherapy or blood transfusion (χ2 = 0.76, 1.97, 0, 2.81, 2.38 and 0.66; all P values > 0.05).
Conclusions: There is a high risk of T. gondii infection among patients with hematological malignancies, and intensified surveillance of T. gondii infection is recommended among patients with hematological malignancies.
期刊介绍:
Chinese Journal of Schistosomiasis Control (ISSN: 1005-6661, CN: 32-1374/R), founded in 1989, is a technical and scientific journal under the supervision of Jiangsu Provincial Health Commission and organised by Jiangsu Institute of Schistosomiasis Control. It is a scientific and technical journal under the supervision of Jiangsu Provincial Health Commission and sponsored by Jiangsu Institute of Schistosomiasis Prevention and Control. The journal carries out the policy of prevention-oriented, control-oriented, nationwide and grassroots, adheres to the tenet of scientific research service for the prevention and treatment of schistosomiasis and other parasitic diseases, and mainly publishes academic papers reflecting the latest achievements and dynamics of prevention and treatment of schistosomiasis and other parasitic diseases, scientific research and management, etc. The main columns are Guest Contributions, Experts‘ Commentary, Experts’ Perspectives, Experts' Forums, Theses, Prevention and Treatment Research, Experimental Research, The main columns include Guest Contributions, Expert Commentaries, Expert Perspectives, Expert Forums, Treatises, Prevention and Control Studies, Experimental Studies, Clinical Studies, Prevention and Control Experiences, Prevention and Control Management, Reviews, Case Reports, and Information, etc. The journal is a useful reference material for the professional and technical personnel of schistosomiasis and parasitic disease prevention and control research, management workers, and teachers and students of medical schools.
The journal is now included in important domestic databases, such as Chinese Core List (8th edition), China Science Citation Database (Core Edition), China Science and Technology Core Journals (Statistical Source Journals), and is also included in MEDLINE/PubMed, Scopus, EBSCO, Chemical Abstract, Embase, Zoological Record, JSTChina, Ulrichsweb, Western Pacific Region Index Medicus, CABI and other international authoritative databases.