细菌性脑膜炎血清和脑脊液c反应蛋白诊断试验的准确性:系统评价和荟萃分析

IF 2.8 Q2 INFECTIOUS DISEASES
Shreya Singh, Kamleshwar Mahto, Amit Kumar, Pramod Kumar, Satish Kumar, Manoj Kumar Prasad
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引用次数: 0

摘要

背景:细菌性脑膜炎是一种严重的感染,由于诊断和治疗的延误,每年导致发病率和死亡率增加。以前的文献表明,脑脊液降钙素原比血清降钙素原更能诊断中枢神经系统(CNS)细菌感染。本荟萃分析旨在探讨血清和脑脊液c反应蛋白(CRP)对细菌性脑膜炎的诊断准确性。材料和方法:检索PubMed、谷歌Scholar、Cochrane Library和谷歌数据库,检索时间为1980年1月1日至2022年6月30日。我们检索了关注c反应蛋白作为成人细菌性脑膜炎生物标志物的前瞻性或回顾性观察性研究。与血清和CSF CRP诊断细菌性脑膜炎相关的文章分别由两位独立专家从电子搜索引擎中可获得的已发表研究中进行探索和检索。采用QUADAS-2评估偏倚风险和研究的学术质量。结果:共识别文章637篇,入选研究22篇。CSF CRP比血清CRP具有更好的诊断价值。CSF CRP的综合敏感性为0.89(95%可信区间[CI], 0.81-0.94),特异性为0.96 (95% CI, 0.92-0.97),曲线下面积(AUC)为0.98 (95% CI, 0.96-0.99),诊断优势比(DOR)为175 (95% CI, 74-410),阳性似然比(PLR)为20 (95% CI, 11.5-34.1),阴性似然比(NLR)为0.11 (95% CI, 0.06-0.21)。而血清CRP的总敏感性为0.80 (95% CI: 0.69-0.88),特异性为0.86 (95% CI, 0.74-0.93), AUC为0.89 (95% CI, 0.86-0.92), DOR为24 (95% CI, 9-62), PLR为6 (95% CI, 2.9-10.7), NLR为0.23 (95% CI, 0.15-0.37)。血清CRP的异质性高于CSF CRP。结论:我们的荟萃分析显示,与血清CRP相比,CSF CRP在确认成人细菌性脑膜炎方面具有更高的敏感性、特异性和PLR,以及更高的AUC和DOR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic Test Accuracy of Serum and Cerebrospinal Fluid C-Reactive Protein in Bacterial Meningitis: A Systematic Review and Meta-Analysis.

Background: Bacterial meningitis is a serious infection leading to increased morbidity and mortality every year due to delayed diagnosis and treatment. Previous literatures had shown that cerebrospinal fluid (CSF) procalcitonin outweighs serum procalcitonin to diagnose bacterial infections of the central nervous system (CNS). Current meta-analysis aims to find the diagnostic accuracy of serum and CSF C-reactive protein (CRP) to diagnose bacterial meningitis.

Material and methods: PubMed, Google Scholar, Cochrane Library and Google databases were searched from 1st January 1980 to 30th June 2022. Observational studies, prospective or retrospective focusing on C-reactive protein as a biomarker for bacterial meningitis in adult patients were searched. The articles related to serum and CSF CRP for diagnosing bacterial meningitis were explored and retrieved separately, by two independent experts from the published studies available in the electronic search engines. The risk of bias and scholarly quality of studies were evaluated by QUADAS-2.

Results: Altogether 637 articles were recognized, out of which 22 studies selected. CSF CRP has shown better diagnostic value than serum CRP. Pooled sensitivity of CSF CRP was 0.89 (95% confidence interval [CI], 0.81-0.94), specificity 0.96 (95% CI, 0.92-0.97), area under the curve (AUC) 0.98 (95% CI, 0.96-0.99), diagnostic odds ratio (DOR) 175 (95% CI, 74-410), positive likelihood ratio (PLR) 20 (95% CI, 11.5-34.1) and negative likelihood ratio (NLR) 0.11 (95% CI, 0.06-0.21). While, pooled sensitivity of serum CRP was 0.80 (95% CI: 0.69-0.88), specificity 0.86 (95% CI, 0.74-0.93), AUC 0.89 (95% CI, 0.86-0.92), DOR 24 (95% CI, 9-62), PLR 6 (95% CI, 2.9-10.7) and NLR 0.23 (95% CI, 0.15-0.37). Heterogeneity was higher for serum CRP than CSF CRP.

Conclusion: Our meta-analysis shows that CSF CRP had higher pooled sensitivity, specificity and PLR along with higher AUC and DOR for confirming bacterial meningitis in adults than serum CRP.

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来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
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