Dongwook Kim, Abraham Puig, Faranak Rabiei, Erial J Hawkins, Talia F Hernandez, Chang K Sung
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Our study aimed to identify the conditions under which SOX2 expression level, viral infection, and replication can reduce or eradicate the glioblastoma stem cells. Analytic work on the existence and stability conditions of equilibrium points with respect to the basic reproduction number are provided. Numerical results were in good agreement with analytic solutions. Our results show that critical threshold levels of both SOX2 and viral replication, which change the stability of equilibrium points through population dynamics such as transcritical and Hopf bifurcations, were observed. These critical thresholds provide the optimal conditions for SOX2 expression levels and viral bursting sizes to enhance therapeutic efficacy of Zika virotherapy against glioblastoma stem cells. This study provides critical insights into optimizing Zika virus-based treatment for glioblastoma by highlighting the essential role of SOX2 in viral infection and replication.</p>","PeriodicalId":48874,"journal":{"name":"Symmetry-Basel","volume":"16 9","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061075/pdf/","citationCount":"0","resultStr":"{\"title\":\"Optimization of SOX2 Expression for Enhanced Glioblastoma Stem Cell Virotherapy.\",\"authors\":\"Dongwook Kim, Abraham Puig, Faranak Rabiei, Erial J Hawkins, Talia F Hernandez, Chang K Sung\",\"doi\":\"10.3390/sym16091186\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Zika virus has been shown to infect glioblastoma stem cells via the membrane receptor <math> <mrow><msub><mi>α</mi> <mi>v</mi></msub> <msub><mi>β</mi> <mn>5</mn></msub> </mrow> </math> , which is activated by the stem-specific transcription factor SOX2. 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These critical thresholds provide the optimal conditions for SOX2 expression levels and viral bursting sizes to enhance therapeutic efficacy of Zika virotherapy against glioblastoma stem cells. 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引用次数: 0
摘要
寨卡病毒已被证明通过膜受体α v β 5感染胶质母细胞瘤干细胞,该受体被干细胞特异性转录因子SOX2激活。由于SOX2的表达水平是病毒治疗成功的重要预测指标,因此了解SOX2在癌症干细胞和寨卡病毒动力学中作用的基本机制非常重要。在本文中,我们建立了一个数学ODE模型来研究SOX2表达水平对寨卡病毒治疗胶质母细胞瘤干细胞的影响。我们的研究旨在确定SOX2表达水平、病毒感染和复制能够减少或根除胶质母细胞瘤干细胞的条件。给出了平衡点关于基本再现数的存在性和稳定性条件的解析工作。数值结果与解析解吻合较好。我们的研究结果表明,SOX2和病毒复制的临界阈值水平,通过跨临界和Hopf分岔等群体动力学改变平衡点的稳定性,被观察到。这些临界阈值为SOX2表达水平和病毒爆发大小提供了最佳条件,以提高寨卡病毒治疗胶质母细胞瘤干细胞的疗效。该研究通过强调SOX2在病毒感染和复制中的重要作用,为优化基于寨卡病毒的胶质母细胞瘤治疗提供了重要见解。
Optimization of SOX2 Expression for Enhanced Glioblastoma Stem Cell Virotherapy.
The Zika virus has been shown to infect glioblastoma stem cells via the membrane receptor , which is activated by the stem-specific transcription factor SOX2. Since the expression level of SOX2 is an important predictive marker for successful virotherapy, it is important to understand the fundamental mechanisms of the role of SOX2 in the dynamics of cancer stem cells and Zika viruses. In this paper, we develop a mathematical ODE model to investigate the effects of SOX2 expression levels on Zika virotherapy against glioblastoma stem cells. Our study aimed to identify the conditions under which SOX2 expression level, viral infection, and replication can reduce or eradicate the glioblastoma stem cells. Analytic work on the existence and stability conditions of equilibrium points with respect to the basic reproduction number are provided. Numerical results were in good agreement with analytic solutions. Our results show that critical threshold levels of both SOX2 and viral replication, which change the stability of equilibrium points through population dynamics such as transcritical and Hopf bifurcations, were observed. These critical thresholds provide the optimal conditions for SOX2 expression levels and viral bursting sizes to enhance therapeutic efficacy of Zika virotherapy against glioblastoma stem cells. This study provides critical insights into optimizing Zika virus-based treatment for glioblastoma by highlighting the essential role of SOX2 in viral infection and replication.
期刊介绍:
Symmetry (ISSN 2073-8994), an international and interdisciplinary scientific journal, publishes reviews, regular research papers and short notes. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided, so that results can be reproduced.