术中使用血管生成抑制剂对增殖性糖尿病视网膜病变手术治疗结果和并发症发生率的影响。

Q3 Medicine
D V Petrachkov, V M Filippov, S Sh Balkar
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引用次数: 0

摘要

增殖性糖尿病视网膜病变(PDR)并发症的治疗,如玻璃体出血和牵引性视网膜脱离,以及黄斑受累,仍然是一个复杂的多因素挑战。血管生成抑制剂(AIs)在患者管理的不同阶段的使用正在研究中。特别是,术中使用人工智能似乎是病理合理的。目的:探讨术中给药对PDR手术治疗结局及并发症发生率的影响。材料和方法:对两组因PDR并发症接受手术的患者进行解剖和功能结果以及术后并发症发生率的比较分析:一组患者术中使用人工智能(60例,60眼),一组患者未使用人工智能(109例,109眼)。在术后早期(1个月)和长期(6个月)随访时进行评估。结果:AIs的使用与术后随访期间较高的术后视力和术后1个月较低的视网膜中央厚度(CRT)显著相关。未使用人工智能系统组的并发症发生率在数字上更高,玻璃体出血和前段新生血管的发生率有临界统计学意义(p=0.079和p=0.096)。两组间糖尿病性黄斑水肿(DME)或玻璃体出血需要翻修手术的发生率无统计学差异。结论:鉴于PDR临床表现的高度可变性,在不同治疗阶段使用ai是合理的。该研究为术中给药人工智能对解剖和功能结果以及并发症发生率的影响提供了有希望的见解。考虑到细胞因子特征,进一步研究AIs效应可能与个性化治疗策略的选择有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The effects of intraoperative use of angiogenesis inhibitors on outcomes and complication rates in the surgical treatment of proliferative diabetic retinopathy].

Treatment of proliferative diabetic retinopathy (PDR) complications, such as vitreous haemorrhage and tractional retinal detachment, as well as macular involvement, remains a complex multifactorial challenge. The use of angiogenesis inhibitors (AIs) at different stages of patient management is being investigated. In particular, intraoperative use of AIs appears to be pathogenetically justified.

Purpose: This study evaluates the effect of intraoperative administration of AIs on the outcomes and complication rates in the surgical treatment of PDR.

Material and methods: A comparative analysis of anatomical and functional outcomes, as well as postoperative complication rates, was performed in two comparable groups of patients who underwent surgery for PDR complications: one with intraoperative AI use (60 cases, 60 eyes), and one without it (109 cases, 109 eyes). The evaluation was conducted at the early (1 month) and long-term (6 months) postoperative follow-ups.

Results: The use of AIs was significantly correlated with higher postoperative visual acuity at all follow-up periods and with lower central retinal thickness (CRT) at 1 month after surgery. The complication rate was numerically higher in the group without AIs use, with borderline statistical significance noted for vitreous hemorrhage and anterior segment neovascularization (p=0.079 and p=0.096, respectively). No statistically significant differences were observed between the groups in the incidence of diabetic macular edema (DME) or cases of vitreous hemorrhage requiring revision surgery.

Conclusion: Given the high variability in clinical presentation of PDR, the use of AIs at different stages of treatment is justified. The study provides promising insights into the effects of intraoperative AIs administration on anatomical and functional outcomes, as well as complication rates. Further research into AIs effects taking into account the cytokine profile may be relevant for the personalized selection of treatment strategies.

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来源期刊
Vestnik oftalmologii
Vestnik oftalmologii Medicine-Ophthalmology
CiteScore
0.80
自引率
0.00%
发文量
129
期刊介绍: The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.
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