Kimberly P Lam, Deborah A Keys, Richard J McMullen
{"title":"马免疫介导性角膜炎的紫花青绿光动力治疗。","authors":"Kimberly P Lam, Deborah A Keys, Richard J McMullen","doi":"10.1111/vop.70027","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To describe infracyanine green-based photodynamic therapy (InfraCG-PDT) and evaluate outcomes in horses with immune-mediated keratitis (IMMK).</p><p><strong>Animals studied: </strong>Medical records from 2014 to 2020 from the Equine Clinic Munich-Riem, Germany, and Auburn University Equine Ophthalmology Service identified horses diagnosed with IMMK following ophthalmic examination that had undergone InfraCG-PDT.</p><p><strong>Procedures: </strong>Multiple intrastromal injections of EmunDo (InfraCG, A.R.C. Laser, Nuernberg, Germany) within an affected quadrant or the entire cornea were treated with diffuse diode laser energy (FOX A.R.C., Laser, Nuernberg, Germany, 500 mW at 30s cycles) irradiation between 75 J (J, quadrant) and 300 J (entire cornea).</p><p><strong>Results: </strong>Fifty-one eyes (22 OS, 19 OD, 10 OU) from 47 horses were included (22 geldings, 20 mares, and 5 stallions) from 15 breeds aged between 4 and 29 years (median 14 years). Individual quadrants (28/51 eyes, 54.9%) or the entire cornea (23/51 eyes, 45.1%) were treated. Complications were defined as immediate: intrastromal fracture (4/51 eyes, 7.8%), intracameral InfraCG (7/51 eyes, 13.7%), and an epithelial blister (1/51 eyes, 1.9%) or short term: prolonged dye retention (51/51 eyes, 100%, with gradual reduction over a 12-week period) and superficial corneal ulceration (15/51 eyes, 29.4%). Globe threatening ulcers (3/51 eyes, 5.9%) resolved without significant complications. IMMK remained inactive (controlled or managed with improvement in ocular lesions) in 31/40 horses (77.5%) during follow-up (mean 223.0 ± 269.3 days; range 14-1095 days), 4/40 horses (10.0%) required additional treatment, and 5/40 horses (12.5%) were lost to follow-up.</p><p><strong>Conclusions: </strong>InfraCG-PDT may be an effective treatment for horses with IMMK. Further studies are needed to optimize this treatment modality.</p>","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Infracyanine Green-Based Photodynamic Therapy for Immune-Mediated Keratitis in Horses.\",\"authors\":\"Kimberly P Lam, Deborah A Keys, Richard J McMullen\",\"doi\":\"10.1111/vop.70027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To describe infracyanine green-based photodynamic therapy (InfraCG-PDT) and evaluate outcomes in horses with immune-mediated keratitis (IMMK).</p><p><strong>Animals studied: </strong>Medical records from 2014 to 2020 from the Equine Clinic Munich-Riem, Germany, and Auburn University Equine Ophthalmology Service identified horses diagnosed with IMMK following ophthalmic examination that had undergone InfraCG-PDT.</p><p><strong>Procedures: </strong>Multiple intrastromal injections of EmunDo (InfraCG, A.R.C. Laser, Nuernberg, Germany) within an affected quadrant or the entire cornea were treated with diffuse diode laser energy (FOX A.R.C., Laser, Nuernberg, Germany, 500 mW at 30s cycles) irradiation between 75 J (J, quadrant) and 300 J (entire cornea).</p><p><strong>Results: </strong>Fifty-one eyes (22 OS, 19 OD, 10 OU) from 47 horses were included (22 geldings, 20 mares, and 5 stallions) from 15 breeds aged between 4 and 29 years (median 14 years). Individual quadrants (28/51 eyes, 54.9%) or the entire cornea (23/51 eyes, 45.1%) were treated. Complications were defined as immediate: intrastromal fracture (4/51 eyes, 7.8%), intracameral InfraCG (7/51 eyes, 13.7%), and an epithelial blister (1/51 eyes, 1.9%) or short term: prolonged dye retention (51/51 eyes, 100%, with gradual reduction over a 12-week period) and superficial corneal ulceration (15/51 eyes, 29.4%). Globe threatening ulcers (3/51 eyes, 5.9%) resolved without significant complications. IMMK remained inactive (controlled or managed with improvement in ocular lesions) in 31/40 horses (77.5%) during follow-up (mean 223.0 ± 269.3 days; range 14-1095 days), 4/40 horses (10.0%) required additional treatment, and 5/40 horses (12.5%) were lost to follow-up.</p><p><strong>Conclusions: </strong>InfraCG-PDT may be an effective treatment for horses with IMMK. Further studies are needed to optimize this treatment modality.</p>\",\"PeriodicalId\":23836,\"journal\":{\"name\":\"Veterinary ophthalmology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary ophthalmology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1111/vop.70027\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary ophthalmology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vop.70027","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Infracyanine Green-Based Photodynamic Therapy for Immune-Mediated Keratitis in Horses.
Objective: To describe infracyanine green-based photodynamic therapy (InfraCG-PDT) and evaluate outcomes in horses with immune-mediated keratitis (IMMK).
Animals studied: Medical records from 2014 to 2020 from the Equine Clinic Munich-Riem, Germany, and Auburn University Equine Ophthalmology Service identified horses diagnosed with IMMK following ophthalmic examination that had undergone InfraCG-PDT.
Procedures: Multiple intrastromal injections of EmunDo (InfraCG, A.R.C. Laser, Nuernberg, Germany) within an affected quadrant or the entire cornea were treated with diffuse diode laser energy (FOX A.R.C., Laser, Nuernberg, Germany, 500 mW at 30s cycles) irradiation between 75 J (J, quadrant) and 300 J (entire cornea).
Results: Fifty-one eyes (22 OS, 19 OD, 10 OU) from 47 horses were included (22 geldings, 20 mares, and 5 stallions) from 15 breeds aged between 4 and 29 years (median 14 years). Individual quadrants (28/51 eyes, 54.9%) or the entire cornea (23/51 eyes, 45.1%) were treated. Complications were defined as immediate: intrastromal fracture (4/51 eyes, 7.8%), intracameral InfraCG (7/51 eyes, 13.7%), and an epithelial blister (1/51 eyes, 1.9%) or short term: prolonged dye retention (51/51 eyes, 100%, with gradual reduction over a 12-week period) and superficial corneal ulceration (15/51 eyes, 29.4%). Globe threatening ulcers (3/51 eyes, 5.9%) resolved without significant complications. IMMK remained inactive (controlled or managed with improvement in ocular lesions) in 31/40 horses (77.5%) during follow-up (mean 223.0 ± 269.3 days; range 14-1095 days), 4/40 horses (10.0%) required additional treatment, and 5/40 horses (12.5%) were lost to follow-up.
Conclusions: InfraCG-PDT may be an effective treatment for horses with IMMK. Further studies are needed to optimize this treatment modality.
期刊介绍：
Veterinary Ophthalmology is a peer-reviewed, international journal that welcomes submission of manuscripts directed towards academic researchers of veterinary ophthalmology, specialists and general practitioners with a strong ophthalmology interest. Articles include those relating to all aspects of:
Clinical and investigational veterinary and comparative ophthalmology;
Prospective and retrospective studies or reviews of naturally occurring ocular disease in veterinary species;
Experimental models of both animal and human ocular disease in veterinary species;
Anatomic studies of the animal eye;
Physiological studies of the animal eye;
Pharmacological studies of the animal eye.
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