羟基磷灰石的新进展:促进可持续和多功能种植体的发展。

IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Odontology Pub Date : 2025-10-01 Epub Date: 2025-04-10 DOI:10.1007/s10266-025-01096-3
Komal Gupta, Niranjan Kaushik, Vikram Sharma, Amit Singh
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引用次数: 0

摘要

生物材料在医疗需求和老龄化人口护理方面的日益相关性导致了这些材料的开发和改性取得了重大进展。羟基磷灰石(HAp)是一种模拟骨矿物组成的生物相容性陶瓷,以其卓越的性能脱颖而出。它在体液中的稳定性和与骨骼结合而不引起毒性或炎症的能力使其成为生物医学应用的主要候选者,特别是在齿科和骨科方面。牙种植体需要与颌骨有一个强大的界面来有效地支撑假体装置,而像HAp这样的磷酸钙基材料涂层可以增强牙种植体的功能。这加强了骨整合,确保了牢固的结合和种植体的使用寿命。HAp既可以人工合成,也可以从哺乳动物骨骼、海洋贝壳和植物等天然来源合成,每种来源都提供独特的微量元素,可以提高其生物活性。HAp的合成涉及不同的技术,包括化学沉淀法和水热技术,每一种技术都会影响材料的最终性能。天然来源的使用尤其有希望,提供了一种可持续的、具有成本效益的替代品,同时保留了基本的生物相容性。因此,本文旨在探讨羟基磷灰石(hydroxyapatite, HAp)的合成、性质及其在生物医学上的应用,并重点介绍羟基磷灰石在提高种植体性能和耐久性方面的作用。它还解决了制造和生物相容性方面的挑战,为该领域的未来发展提供了见解。通过解决当前在制造和生物相容性方面的挑战,HAp为更有效和持久的牙科治疗铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review on innovations in hydroxyapatite: advancing sustainable and multifunctional dental implants.

The increasing relevance of biomaterials in medical curements and the care of aging populations has led to significant advancements in the development and modification of these materials. Hydroxyapatite (HAp), a biocompatible ceramic that mimics the composition of bone mineral, stands out for its remarkable abilities. Its stability in body fluids and ability to integrate with bone without causing toxicity or inflammation made it a prime candidate for biomedical utilization, particularly in odontology and orthopedics. Dental implants, which necessitate a strong interface with the jawbone to effectively support prosthetic devices, are enhanced by coatings of calcium phosphate-based materials like HAp. This enhances osseointegration, ensuring a strong bond and longevity of the implant. HAp may be synthesized both synthetically and from natural sources like mammalian bones, marine shells, and plants, each offering unique trace elements that improve its bioactivity. The synthesis of HAp involves differential technique, including chemical precipitation, and hydrothermal techniques, each impacting the final abilities of the material. The use of natural sources is especially promising, providing a sustainable, cost-effective alternative that retains essential biocompatibility. Hence, this article aims to explore the synthesis, properties, and biomedical applications of hydroxyapatite (HAp), with a special emphasis on its role in improving the performance and durability of dental implants. It also addresses the challenges in manufacturing and biocompatibility, offering insights into future advancements in this field. By addressing current challenges in manufacturing and biocompatibility, HAp paves the way for more effective and long-lasting dental treatments.

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来源期刊
Odontology
Odontology 医学-牙科与口腔外科
CiteScore
5.30
自引率
4.00%
发文量
91
审稿时长
>12 weeks
期刊介绍: The Journal Odontology covers all disciplines involved in the fields of dentistry and craniofacial research, including molecular studies related to oral health and disease. Peer-reviewed articles cover topics ranging from research on human dental pulp, to comparisons of analgesics in surgery, to analysis of biofilm properties of dental plaque.
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