综述：设计新一代人偏肺病毒（HMPV）疫苗。

IF 2.1 Q4 IMMUNOLOGY

Clinical and Experimental Vaccine Research Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI:10.7774/cevr.2025.14.e12

Mohammed Ibrahim Saeed

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引用次数: 0

摘要

最近流行的人偏肺病毒（HMPV）是一种严重的呼吸道感染，影响免疫功能低下的人、老人和儿童。HMPV感染可引起显著的发病率，包括肺炎、细支气管炎，并使慢性呼吸道疾病恶化。尽管有临床负担，但仍然没有获得许可的HMPV疫苗。这篇简短的综述探讨了下一代HMPV疫苗的机制、所涉及的基因、重要的表位、它们引发的免疫反应以及对群体免疫的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Minireview: Designing next generation human metapneumovirus (HMPV) vaccine.

The recently circulating human metapneumovirus (HMPV) is a serious respiratory infection that affects immunocompromised persons, the elderly, and children. HMPV infections can cause significant morbidity, including pneumonia, bronchiolitis, and worsen chronic respiratory diseases. Despite the clinical burden, there is still no licensed HMPV vaccine. This short review examines the mechanisms underpinning next generation HMPV vaccines, the gene involved, the significant epitopes, the immunological responses they elicit, and the potential impact on herd immunity.

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来源期刊

Clinical and Experimental Vaccine Research IMMUNOLOGY-

CiteScore

3.70

自引率

3.70%

发文量

审稿时长

8 weeks

期刊介绍： Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide