{"title":"中国2型糖尿病患者SADI-S与BMI 2的1年预后：一项单中心回顾性研究","authors":"Zheng Zhang, Tao Jiang","doi":"10.1007/s11695-025-07872-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence on the efficacy and safety of single anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in treating type 2 diabetes mellitus (T2DM) in patients with body mass index (BMI) < 35 kg/m<sup>2</sup>.</p><p><strong>Methods: </strong>This study included clinical data from 22 T2DM patients with BMI < 35 kg/m<sup>2</sup> who received SADI-S treatment. Changes in diabetes-related indicators, weight-related indicators, and patient nutritional outcomes were analyzed.</p><p><strong>Results: </strong>SADI-S was successfully performed in all 22 cases, with no conversions to laparotomy or resulting deaths. The incidence of surgical complications was 4.54% (1/22). One-year postsurgery, there was a significant decrease in BMI from 32.42 ± 2.18 to 22.11 ± 1.86 kg/m<sup>2</sup> (P < 0.05) and a significant decrease in mean HbA1c from 8.76 ± 1.74 to 5.25 ± 0.76% (P < 0.05). The %EWL and %TWL were 145.78 ± 35.97% and 31.60 ± 6.34% respectively at 1 year. The remission rate for T2DM was 94.7% (18/19) at 1 year. Following SADI-S, the incidence rates of zinc deficiency and vitamin D deficiency at 1 year were 38.46% (5/13) and 30.77% (4/13), respectively, significantly higher than presurgery.</p><p><strong>Conclusions: </strong>SADI-S is considered an efficient, safe, and feasible surgical approach for patients with T2DM and a BMI < 35 kg/m<sup>2</sup>. Nevertheless, additional research, including potentially multi-center collaborative studies, is warranted to assess the procedure's long-term outcomes.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":"2142-2149"},"PeriodicalIF":2.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129869/pdf/","citationCount":"0","resultStr":"{\"title\":\"One-Year Outcomes of SADI-S in Chinese Patients with Type 2 Diabetes and BMI < 35 kg/m<sup>2</sup>: A Single-Center Retrospective Study.\",\"authors\":\"Zheng Zhang, Tao Jiang\",\"doi\":\"10.1007/s11695-025-07872-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is limited evidence on the efficacy and safety of single anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in treating type 2 diabetes mellitus (T2DM) in patients with body mass index (BMI) < 35 kg/m<sup>2</sup>.</p><p><strong>Methods: </strong>This study included clinical data from 22 T2DM patients with BMI < 35 kg/m<sup>2</sup> who received SADI-S treatment. Changes in diabetes-related indicators, weight-related indicators, and patient nutritional outcomes were analyzed.</p><p><strong>Results: </strong>SADI-S was successfully performed in all 22 cases, with no conversions to laparotomy or resulting deaths. The incidence of surgical complications was 4.54% (1/22). One-year postsurgery, there was a significant decrease in BMI from 32.42 ± 2.18 to 22.11 ± 1.86 kg/m<sup>2</sup> (P < 0.05) and a significant decrease in mean HbA1c from 8.76 ± 1.74 to 5.25 ± 0.76% (P < 0.05). The %EWL and %TWL were 145.78 ± 35.97% and 31.60 ± 6.34% respectively at 1 year. The remission rate for T2DM was 94.7% (18/19) at 1 year. Following SADI-S, the incidence rates of zinc deficiency and vitamin D deficiency at 1 year were 38.46% (5/13) and 30.77% (4/13), respectively, significantly higher than presurgery.</p><p><strong>Conclusions: </strong>SADI-S is considered an efficient, safe, and feasible surgical approach for patients with T2DM and a BMI < 35 kg/m<sup>2</sup>. Nevertheless, additional research, including potentially multi-center collaborative studies, is warranted to assess the procedure's long-term outcomes.</p>\",\"PeriodicalId\":19460,\"journal\":{\"name\":\"Obesity Surgery\",\"volume\":\" \",\"pages\":\"2142-2149\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129869/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11695-025-07872-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11695-025-07872-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/26 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
One-Year Outcomes of SADI-S in Chinese Patients with Type 2 Diabetes and BMI < 35 kg/m2: A Single-Center Retrospective Study.
Background: There is limited evidence on the efficacy and safety of single anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in treating type 2 diabetes mellitus (T2DM) in patients with body mass index (BMI) < 35 kg/m2.
Methods: This study included clinical data from 22 T2DM patients with BMI < 35 kg/m2 who received SADI-S treatment. Changes in diabetes-related indicators, weight-related indicators, and patient nutritional outcomes were analyzed.
Results: SADI-S was successfully performed in all 22 cases, with no conversions to laparotomy or resulting deaths. The incidence of surgical complications was 4.54% (1/22). One-year postsurgery, there was a significant decrease in BMI from 32.42 ± 2.18 to 22.11 ± 1.86 kg/m2 (P < 0.05) and a significant decrease in mean HbA1c from 8.76 ± 1.74 to 5.25 ± 0.76% (P < 0.05). The %EWL and %TWL were 145.78 ± 35.97% and 31.60 ± 6.34% respectively at 1 year. The remission rate for T2DM was 94.7% (18/19) at 1 year. Following SADI-S, the incidence rates of zinc deficiency and vitamin D deficiency at 1 year were 38.46% (5/13) and 30.77% (4/13), respectively, significantly higher than presurgery.
Conclusions: SADI-S is considered an efficient, safe, and feasible surgical approach for patients with T2DM and a BMI < 35 kg/m2. Nevertheless, additional research, including potentially multi-center collaborative studies, is warranted to assess the procedure's long-term outcomes.
期刊介绍：
Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions.
Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.
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