突破快感缺乏症：氯胺酮如何重新点燃对奖励的渴望。

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-05-07 DOI:10.1016/j.neuron.2025.03.025

Colleen A McClung

引用次数: 0

摘要

在这一期的《神经元》中，Pignatelli等人发现氯胺酮可以逆转伏隔核D1表达多巴胺受体的中棘神经元（D1- msn）中兴奋性突触的应激诱导变化，这些变化对于治疗快感缺乏样行为是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Breaking through anhedonia: How ketamine reignites the drive for rewards.

In this issue of Neuron, Pignatelli et al.¹ find that ketamine reverses stress-induced changes in excitatory synapses in nucleus accumbens D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs) and that these changes are necessary for the treatment of anhedonia-like behavior.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.