布比卡因和吗啡对去势犬脑电图及术后疼痛的影响。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia Pub Date : 2025-03-15 DOI:10.1016/j.vaa.2025.03.007

Robert K. Sawicki , Kavitha Kongara , Mike A. Gieseg , Venkata S.R. Dukkipati , Craig B. Johnson

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引用次数: 0

摘要

目的：比较局部布比卡因与全身吗啡单独或联合用药对去势犬脑电图（EEG）和术后疼痛的影响。研究设计：随机盲法临床研究。动物：一组21只健康的杂交狗。方法：犬随机分为吗啡组（0.5 mg kg-1）、布比卡因组（2 mg kg-1）和布比卡因组（2 mg kg-1），每组7只。预用药为乙酰丙嗪（0.05 mg kg-1）（所有组）和吗啡（仅吗啡和联合组）皮下注射。麻醉以静脉异丙酚诱导起效，氟烷氧维持。布比卡因组和联合组手术前30分钟布比卡因在切口部位浸润。记录收缩压（SAP）、心率（HR）和血红蛋白氧饱和度（SpO2）。所有的狗都通过常规的前列腺前入路进行了开放性阉割。麻醉过程中记录脑电图。中位数频率（F50）、95%谱边缘频率（F95）和总功率（pot）由原始脑电图迹线得到。术后1、3、6和9小时使用格拉斯哥综合疼痛量表评估疼痛。分别采用广义线性混合模型和Wilcoxon-Mann-Whitney赔率宏观比较各组脑电图和疼痛评分。数据以均数±标准差表示（p < 0.05）。结果：吗啡组和布比卡因组在去势过程中F50和F95显著高于联合用药组，pto显著低于联合用药组。布比卡因组与联合用药组术后疼痛评分无显著差异；两组的疼痛评分都明显低于吗啡组。SAP、HR、SpO2组间差异不显著。结论及临床意义：手术前切口浸润布比卡因，单独或与全身阿片类药物，可减少阉割犬术中痛觉和术后疼痛。

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Effects of bupivacaine and morphine on the electroencephalogram and postoperative pain in castrated dogs

Objective

To compare the effects of locally administered bupivacaine and systemic morphine, separately or in combination, on the electroencephalogram (EEG) and postoperative pain in castrated dogs.

Study design

Randomized blinded clinical study.

Animals

A group of 21 healthy mixed-breed dogs.

Methods

Dogs were randomly assigned to one of three groups (n = 7 per group): morphine (0.5 mg kg^–1), bupivacaine (2 mg kg^–1) or a combination of both. Premedication consisted of acepromazine (0.05 mg kg^–1) (all groups) and morphine (morphine and combination groups only) administered subcutaneously. Anaesthesia was induced with intravenous propofol to effect and maintained with halothane in oxygen. Bupivacaine was infiltrated at the incision site 30 minutes prior to surgery in bupivacaine and combination groups. Systolic arterial blood pressure (SAP), heart rate (HR) and haemoglobin oxygen saturation (SpO₂) were recorded. All dogs underwent an open castration via a routine prescrotal approach. EEG was recorded throughout anaesthesia. Median frequency (F₅₀), 95% spectral edge frequency (F₉₅) and total power (P_tot) were derived from raw EEG traces. Postoperative pain was assessed at 1, 3, 6 and 9 hours using a short form of the Glasgow Composite Measure Pain Scale. EEG and pain scores were compared among groups using a generalized linear mixed model and Wilcoxon–Mann–Whitney odds macro, respectively. Data were presented as mean ± standard deviation (p < 0.05).

Results

The morphine and bupivacaine groups had a significantly higher F₅₀ and F₉₅ and a lower P_tot than the combination group during castration. Postoperative pain scores did not significantly differ between bupivacaine and combination groups; both groups had significantly lower pain scores than the morphine group. SAP, HR and SpO₂ did not differ significantly among groups.

Conclusions and clinical relevance

Presurgical incisional infiltration of bupivacaine, alone or with a systemic opioid, reduces intraoperative nociception and postoperative pain in dogs undergoing castration.

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来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.