用稳定的具有抗血栓特性的亲水性涂层敷料抗菌铂负载聚氨酯材料。

Shuai Gao, Zheng Liu, Wei Zeng, Xi Liu, Fanjun Zhang, Dimeng Wu, Yunbing Wang
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引用次数: 0

摘要

血液与医疗材料接触导致的血栓形成和感染是显著的临床并发症,这两种现象之间存在着相互加强的关系。因此,开发同时释放杀菌剂和表现出被动抗血栓特性的亲水涂层是至关重要的。在这项工作中,我们采用了一种简单、易于执行、易于放大的策略来合成含有铂配合物的抗菌聚氨酯基质,然后通过表面引发聚合在其表面构建基于磷胆碱的亲水性涂层。抗菌作用主要来自铂络合物离子的缓释机制,而磷胆碱涂层具有显著的抗血栓特性。这两种功能在材料内独立和协同运作,以提供强大的抗菌和抗血栓性能。体外和体内实验验证了该复合材料在抑制细菌生长和防止血栓形成方面的有效性。此外,组织分析和免疫检测证实了涂层材料具有良好的生物相容性和抗炎作用。因此,开发的具有高效抗菌和抗血栓作用的创新涂层显示出巨大的希望,作为一种有效的策略,可以减轻临床环境中涉及血液接触医疗设备和相关植入物的感染和血栓形成相关风险。 。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dressing antibacterial platinum loaded polyurethane materials by a stable hydrophilic coating with robust antithrombotic properties.

Thrombus formation and infection resulting from blood contact with medical materials represent significant clinical complications characterized by a mutually reinforcing relationship between the two phenomena. Consequently, the development of hydrophilic coatings that simultaneously release bactericidal agents and exhibit passive antithrombotic properties is of paramount importance. In this work, we employed a straightforward, easily executable, and amenable to scale-up strategy to synthesize an antibacterial polyurethane matrix containing platinum complex, followed by the construction of a phosphorylcholine-based hydrophilic coating on its surface via surface-initiated polymerization. The antibacterial efficacy arises from the sustained release mechanism of platinum complex ions, while the phosphorylcholine coating exhibits remarkable antithrombotic characteristics. These two functionalities operate both independently and synergistically within the material to provide robust antibacterial and antithrombotic performance.In vitroandin vivoexperiments validated the effectiveness of this composite material in inhibiting bacterial growth and preventing thrombus formation. Furthermore, histological analysis along with immunological detection confirmed that the coating material has excellent biocompatibility coupled with anti-inflammatory effects. Therefore, the developed innovative coating with efficient antibacterial and antithrombotic effects shows great promise as an effective strategy for mitigating risks associated with infections and thrombus formation in clinical settings involving blood-contacting medical devices and related implants.

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