巨噬-中性粒细胞程序驱动乳腺癌的发生。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI:10.1016/j.trecan.2025.04.001

Lukas Bolini, Simon R V Knott, Lorenzo Galluzzi

引用次数: 0

摘要

乳腺癌逃避免疫监视的分子和细胞途径仍然知之甚少。Camargo等人最近的数据表明，在导管巨噬细胞招募到肿瘤微环境时，异质中性粒细胞群体可以在维持乳腺肿瘤发生的空间壁龛内与恶性细胞建立物理接触。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A macrophage-neutrophil program drives mammary carcinogenesis.

The molecular and cellular pathways through which breast cancer evades immunosurveillance remain poorly understood. Recent data from Camargo et al. demonstrate that - on recruitment to the tumor microenvironment by ductal macrophages - a heterogeneous population of neutrophils can establish physical contacts with malignant cells within spatial niches that sustain mammary oncogenesis.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.