衰老对人类基底前脑-齿状回静息状态功能连接的影响。

IF 4.6 2区医学 Q1 GERIATRICS & GERONTOLOGY

International psychogeriatrics Pub Date : 2025-04-08 DOI:10.1016/j.inpsyc.2025.100072

Yuting Luo, Rong Lin, Yuanjiao Yan, Chenshan Huang, Xiaochun Chen, Hong Li

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引用次数: 0

摘要

基底前脑和齿状回是各种认知功能的组成部分。先前的研究已经确定了这些区域的结构变化与衰老有关。然而，基底前脑和齿状回之间的功能相互作用在整个生命周期中尚未得到很好的阐明。在这项研究中，我们分析了102名年龄在56-85岁之间的成年人的静息状态功能磁共振成像数据。我们的研究结果揭示了年龄与所有参与者的基底前脑和齿状回之间的功能连接强度之间存在显著的负相关。这些结果增强了我们对人类大脑衰老背景下基底前脑和齿状回之间相互作用的理解。

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Effect of aging on resting state functional connectivity between basal forebrain and dentate gyrus in humans.

The basal forebrain and dentate gyrus are integral to various cognitive functions. Prior research has identified structural alterations in these regions associated with aging. Nonetheless, the functional interactions between the basal forebrain and dentate gyrus over the lifespan are not well elucidated. In this study, we analyzed resting-state functional magnetic resonance imaging data from a convenience sample of 102 adults aged 56-85 years. Our findings reveal a significant negative correlation between age and the strength of functional connectivity between the basal forebrain and the dentate gyrus across all participants. These results enhance our understanding of the interaction between the basal forebrain and dentate gyrus within the context of aging in the human brain.

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来源期刊

International psychogeriatrics 医学-精神病学

CiteScore

9.10

自引率

8.60%

发文量

217

审稿时长

3-6 weeks

期刊介绍： A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.