抗疟疾药物的疗效和耐药性：来自乌干达北部的见解。

IF 1.5 4区医学 Q3 PARASITOLOGY

Parasitology International Pub Date : 2025-05-08 DOI:10.1016/j.parint.2025.103083

Toshihiro Mita

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引用次数: 0

摘要

在几乎所有地区，联合使用青蒿素是治疗恶性疟原虫疟疾的一线药物。然而，到本世纪头十年后期，在大湄公河次区域出现了部分耐药性，其特征是治疗后寄生虫清除延迟，并迅速扩大了其范围。自2013年以来，我们在乌干达北部开展了全面的疟疾耐药性监测。2014年，我们发现了体外青蒿素耐药性，到2017年，也观察到临床部分耐药。此外，我们早在2013年就发现该地区氯喹敏感性再次出现，比乌干达其他地区更早。本综述旨在总结我们在乌干达北部的研究结果，并将其与在其他地区进行的类似研究相结合。

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Antimalarial drug efficacy and resistance: Insights from northern Uganda

Artemisinin in combination is the first-line treatment for Plasmodium falciparum malaria in almost all regions. However, by the late 2000s, partial resistance, characterized by delayed parasite clearance after treatment, emerged in the Greater Mekong Subregion and rapidly expanded its range. Since 2013, we have conducted comprehensive malaria drug resistance surveillance in northern Uganda. In 2014, we identified in vitro artemisinin resistance, and by 2017, clinical partial resistance had also been observed. Additionally, we discovered the re-emergence of chloroquine sensitivity in this region as early as 2013, earlier than in the other parts of Uganda. This review aims to summarize our findings from northern Uganda, contextualizing them within similar studies conducted in other regions.

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来源期刊

Parasitology International 医学-寄生虫学

CiteScore

4.00

自引率

10.50%

发文量

140

审稿时长

61 days

期刊介绍： Parasitology International provides a medium for rapid, carefully reviewed publications in the field of human and animal parasitology. Original papers, rapid communications, and original case reports from all geographical areas and covering all parasitological disciplines, including structure, immunology, cell biology, biochemistry, molecular biology, and systematics, may be submitted. Reviews on recent developments are invited regularly, but suggestions in this respect are welcome. Letters to the Editor commenting on any aspect of the Journal are also welcome.