Kyriaki Cholidou, Nektarios Anagnostopoulos, Konstantinos Bartziokas, Konstantinos Vafeiadis, Agamemnon Bakakos, Aggelos Vontetsianos, Vasiliki Gogou, Zoi Sotiropoulou, Christina Anagnostopoulou, Anna Papasarantou, Paschalis Steiropoulos, Petros Bakakos, Andriana I Papaioannou
{"title":"平均血小板体积和红细胞分布宽度与阻塞性睡眠呼吸暂停综合征严重程度的相关性。","authors":"Kyriaki Cholidou, Nektarios Anagnostopoulos, Konstantinos Bartziokas, Konstantinos Vafeiadis, Agamemnon Bakakos, Aggelos Vontetsianos, Vasiliki Gogou, Zoi Sotiropoulou, Christina Anagnostopoulou, Anna Papasarantou, Paschalis Steiropoulos, Petros Bakakos, Andriana I Papaioannou","doi":"10.4103/lungindia.lungindia_422_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Mean platelet volume (MPV) and red blood cll distribution width (RDW) have been assosiated with sleep apnea syndrome severity.</p><p><strong>Objective: </strong>To investigate the correlation of mean platelet volume and red blood cell distribution width with obesity sleep apnoea syndrome (OSAS) severity.</p><p><strong>Methods: </strong>Ninety patients underwent PSG. Patients with an apnoea-hypopnoea index (AHI) <5 were used as controls. Patients with AHI >5 were divided into mild: 5 ≤ AHI <15, moderate: 15≤ AHI <30 and severe OSAS: AHI ≥30. Patients >65 years, with body mass index (BMI) >40, central sleep apnoea syndrome, cardiovascular or other significant comorbidities were excluded. Blood sample collection occurred one day before polysomnography (PSG).</p><p><strong>Results: </strong>Sixty-four patients were included in our study. Fifty-seven (89.1%) had OSAS (16% mild, 25% moderate and 48.4% severe) while the remaining 7 (10.1%) were used as controls. MPV was similar among groups [8.1 (7.1, 9.2) vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = .930 for control, mild, moderate and severe OSAS, respectively]. RDW did not differ between OSAS patients and control [median (IQR) 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = .950], while there was no significant difference among different stages of OSAS severity [14.0 (13.5, 16.7) vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = .517] for control, mild, moderate and severe OSAS, respectively.</p><p><strong>Conclusion: </strong>OSAS patients have elevated levels of RDW and MPV compared to controls; however, there was no association between OSAS severity and MPV or RDW.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 3","pages":"179-185"},"PeriodicalIF":1.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097666/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation of mean platelet volume and red blood cell distribution width with obstructive sleep apnoea syndrome severity.\",\"authors\":\"Kyriaki Cholidou, Nektarios Anagnostopoulos, Konstantinos Bartziokas, Konstantinos Vafeiadis, Agamemnon Bakakos, Aggelos Vontetsianos, Vasiliki Gogou, Zoi Sotiropoulou, Christina Anagnostopoulou, Anna Papasarantou, Paschalis Steiropoulos, Petros Bakakos, Andriana I Papaioannou\",\"doi\":\"10.4103/lungindia.lungindia_422_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Mean platelet volume (MPV) and red blood cll distribution width (RDW) have been assosiated with sleep apnea syndrome severity.</p><p><strong>Objective: </strong>To investigate the correlation of mean platelet volume and red blood cell distribution width with obesity sleep apnoea syndrome (OSAS) severity.</p><p><strong>Methods: </strong>Ninety patients underwent PSG. Patients with an apnoea-hypopnoea index (AHI) <5 were used as controls. Patients with AHI >5 were divided into mild: 5 ≤ AHI <15, moderate: 15≤ AHI <30 and severe OSAS: AHI ≥30. Patients >65 years, with body mass index (BMI) >40, central sleep apnoea syndrome, cardiovascular or other significant comorbidities were excluded. Blood sample collection occurred one day before polysomnography (PSG).</p><p><strong>Results: </strong>Sixty-four patients were included in our study. Fifty-seven (89.1%) had OSAS (16% mild, 25% moderate and 48.4% severe) while the remaining 7 (10.1%) were used as controls. MPV was similar among groups [8.1 (7.1, 9.2) vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = .930 for control, mild, moderate and severe OSAS, respectively]. RDW did not differ between OSAS patients and control [median (IQR) 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = .950], while there was no significant difference among different stages of OSAS severity [14.0 (13.5, 16.7) vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = .517] for control, mild, moderate and severe OSAS, respectively.</p><p><strong>Conclusion: </strong>OSAS patients have elevated levels of RDW and MPV compared to controls; however, there was no association between OSAS severity and MPV or RDW.</p>\",\"PeriodicalId\":47462,\"journal\":{\"name\":\"Lung India\",\"volume\":\"42 3\",\"pages\":\"179-185\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097666/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lung India\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/lungindia.lungindia_422_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/lungindia.lungindia_422_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
摘要
平均血小板体积（MPV）和红细胞分布宽度（RDW）与睡眠呼吸暂停综合征的严重程度相关。目的：探讨平均血小板体积和红细胞分布宽度与肥胖睡眠呼吸暂停综合征（OSAS）严重程度的相关性。方法：90例患者行PSG检查。呼吸暂停低通气指数（AHI）为5的患者分为轻度：5≤AHI 65岁，排除体重指数（BMI） bbb40、中枢性睡眠呼吸暂停综合征、心血管或其他显著合并症。血样采集于多导睡眠图（PSG）检查前一天。结果：64例患者纳入我们的研究。57例（89.1%）有OSAS（轻度16%，中度25%，重度48.4%），其余7例（10.1%）作为对照。各组间MPV相似[对照组、轻度、中度和重度OSAS分别为8.1 (7.1,9.2)vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = 0.930]。OSAS患者与对照组之间的RDW无显著差异[中位数（IQR） 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = 0.950]，而对照组、轻度、中度和重度OSAS不同严重程度阶段之间的RDW差异无显著性[14.0 (13.5,16.7)vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = 0.517]。结论：与对照组相比，OSAS患者的RDW和MPV水平升高；然而，OSAS严重程度与MPV或RDW之间没有关联。
Correlation of mean platelet volume and red blood cell distribution width with obstructive sleep apnoea syndrome severity.
Introduction: Mean platelet volume (MPV) and red blood cll distribution width (RDW) have been assosiated with sleep apnea syndrome severity.
Objective: To investigate the correlation of mean platelet volume and red blood cell distribution width with obesity sleep apnoea syndrome (OSAS) severity.
Methods: Ninety patients underwent PSG. Patients with an apnoea-hypopnoea index (AHI) <5 were used as controls. Patients with AHI >5 were divided into mild: 5 ≤ AHI <15, moderate: 15≤ AHI <30 and severe OSAS: AHI ≥30. Patients >65 years, with body mass index (BMI) >40, central sleep apnoea syndrome, cardiovascular or other significant comorbidities were excluded. Blood sample collection occurred one day before polysomnography (PSG).
Results: Sixty-four patients were included in our study. Fifty-seven (89.1%) had OSAS (16% mild, 25% moderate and 48.4% severe) while the remaining 7 (10.1%) were used as controls. MPV was similar among groups [8.1 (7.1, 9.2) vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = .930 for control, mild, moderate and severe OSAS, respectively]. RDW did not differ between OSAS patients and control [median (IQR) 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = .950], while there was no significant difference among different stages of OSAS severity [14.0 (13.5, 16.7) vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = .517] for control, mild, moderate and severe OSAS, respectively.
Conclusion: OSAS patients have elevated levels of RDW and MPV compared to controls; however, there was no association between OSAS severity and MPV or RDW.
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