Ignacio Otero Balda, Laura E Selmic, Polina Stamenova, Matthew Simpson, Victoria J Lipscomb, Anne Kummeling, Nausikaa Devriendt, Hilde de Rooster, Katarzyna M Grzywa, Michael S Tivers, Guillaume Chanoit, Adrien Maggiar, Jean-Philippe Billet, Román Soto Muñoz, Alberto Oramas, Ameet Singh, Ronan A Mullins
{"title":"单先天性门静脉分流手术后神经症状减弱的猫短期生存的预后因素","authors":"Ignacio Otero Balda, Laura E Selmic, Polina Stamenova, Matthew Simpson, Victoria J Lipscomb, Anne Kummeling, Nausikaa Devriendt, Hilde de Rooster, Katarzyna M Grzywa, Michael S Tivers, Guillaume Chanoit, Adrien Maggiar, Jean-Philippe Billet, Román Soto Muñoz, Alberto Oramas, Ameet Singh, Ronan A Mullins","doi":"10.1111/vsu.14267","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To report 30-day survival of cats that experienced postattenuation neurologic signs (PANS) after surgical attenuation of a single congenital portosystemic shunt (cPSS), and to investigate prognostic factors for short-term survival.</p><p><strong>Study design: </strong>Multi-institutional retrospective study.</p><p><strong>Sample population: </strong>A total of 59 cats with cPSS that experienced PANS.</p><p><strong>Methods: </strong>The medical records of 10 institutions were retrospectively reviewed to identify cats that underwent cPSS attenuation from January 1, 2010 through June 30, 2023 and developed PANS within 7 days postoperatively. Exclusion criteria were cats with arteriovenous malformation and cats lost-to-follow-up prior to 30 days. Logistic regression identified factors associated with 30-day survival. Odds Ratios (OR) and 95% CIs were calculated.</p><p><strong>Results: </strong>A total of 46 (78.0%) PANS-affected cats survived to 30 days. A total of 13 (50.0%) of 26 cats that experienced postattenuation seizures (PAS) survived to 30 days, with most non-surviving cats experiencing generalized PAS. Cats that experienced PAS (p < .01, OR: 0.015, 95% CI: <0.001-0.281) and treatment of PANS with propofol (p < .01, OR: 0.112, 95% CI: 0.022-0.569) were associated with decreased odds of 30-day survival.</p><p><strong>Conclusion: </strong>Most cats that experienced PANS survived to 30 days; however, short-term survival rate was worse for cats that experienced PAS.</p><p><strong>Clinical significance: </strong>The prognosis for cats that experience PANS is generally good but experiencing PAS and requiring treatment with propofol are negative prognostic factors.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic factors for short-term survival of cats that experienced postattenuation neurologic signs after surgical attenuation of single congenital portosystemic shunts.\",\"authors\":\"Ignacio Otero Balda, Laura E Selmic, Polina Stamenova, Matthew Simpson, Victoria J Lipscomb, Anne Kummeling, Nausikaa Devriendt, Hilde de Rooster, Katarzyna M Grzywa, Michael S Tivers, Guillaume Chanoit, Adrien Maggiar, Jean-Philippe Billet, Román Soto Muñoz, Alberto Oramas, Ameet Singh, Ronan A Mullins\",\"doi\":\"10.1111/vsu.14267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To report 30-day survival of cats that experienced postattenuation neurologic signs (PANS) after surgical attenuation of a single congenital portosystemic shunt (cPSS), and to investigate prognostic factors for short-term survival.</p><p><strong>Study design: </strong>Multi-institutional retrospective study.</p><p><strong>Sample population: </strong>A total of 59 cats with cPSS that experienced PANS.</p><p><strong>Methods: </strong>The medical records of 10 institutions were retrospectively reviewed to identify cats that underwent cPSS attenuation from January 1, 2010 through June 30, 2023 and developed PANS within 7 days postoperatively. Exclusion criteria were cats with arteriovenous malformation and cats lost-to-follow-up prior to 30 days. Logistic regression identified factors associated with 30-day survival. Odds Ratios (OR) and 95% CIs were calculated.</p><p><strong>Results: </strong>A total of 46 (78.0%) PANS-affected cats survived to 30 days. A total of 13 (50.0%) of 26 cats that experienced postattenuation seizures (PAS) survived to 30 days, with most non-surviving cats experiencing generalized PAS. Cats that experienced PAS (p < .01, OR: 0.015, 95% CI: <0.001-0.281) and treatment of PANS with propofol (p < .01, OR: 0.112, 95% CI: 0.022-0.569) were associated with decreased odds of 30-day survival.</p><p><strong>Conclusion: </strong>Most cats that experienced PANS survived to 30 days; however, short-term survival rate was worse for cats that experienced PAS.</p><p><strong>Clinical significance: </strong>The prognosis for cats that experience PANS is generally good but experiencing PAS and requiring treatment with propofol are negative prognostic factors.</p>\",\"PeriodicalId\":23667,\"journal\":{\"name\":\"Veterinary Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Surgery\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1111/vsu.14267\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Surgery","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vsu.14267","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Prognostic factors for short-term survival of cats that experienced postattenuation neurologic signs after surgical attenuation of single congenital portosystemic shunts.
Objective: To report 30-day survival of cats that experienced postattenuation neurologic signs (PANS) after surgical attenuation of a single congenital portosystemic shunt (cPSS), and to investigate prognostic factors for short-term survival.
Study design: Multi-institutional retrospective study.
Sample population: A total of 59 cats with cPSS that experienced PANS.
Methods: The medical records of 10 institutions were retrospectively reviewed to identify cats that underwent cPSS attenuation from January 1, 2010 through June 30, 2023 and developed PANS within 7 days postoperatively. Exclusion criteria were cats with arteriovenous malformation and cats lost-to-follow-up prior to 30 days. Logistic regression identified factors associated with 30-day survival. Odds Ratios (OR) and 95% CIs were calculated.
Results: A total of 46 (78.0%) PANS-affected cats survived to 30 days. A total of 13 (50.0%) of 26 cats that experienced postattenuation seizures (PAS) survived to 30 days, with most non-surviving cats experiencing generalized PAS. Cats that experienced PAS (p < .01, OR: 0.015, 95% CI: <0.001-0.281) and treatment of PANS with propofol (p < .01, OR: 0.112, 95% CI: 0.022-0.569) were associated with decreased odds of 30-day survival.
Conclusion: Most cats that experienced PANS survived to 30 days; however, short-term survival rate was worse for cats that experienced PAS.
Clinical significance: The prognosis for cats that experience PANS is generally good but experiencing PAS and requiring treatment with propofol are negative prognostic factors.
期刊介绍：
Veterinary Surgery, the official publication of the American College of Veterinary Surgeons and European College of Veterinary Surgeons, is a source of up-to-date coverage of surgical and anesthetic management of animals, addressing significant problems in veterinary surgery with relevant case histories and observations.
It contains original, peer-reviewed articles that cover developments in veterinary surgery, and presents the most current review of the field, with timely articles on surgical techniques, diagnostic aims, care of infections, and advances in knowledge of metabolism as it affects the surgical patient. The journal places new developments in perspective, encompassing new concepts and peer commentary to help better understand and evaluate the surgical patient.
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