肾结石和氧化应激。乳头状肾结石的类型。

IF 2 2区 医学 Q2 UROLOGY & NEPHROLOGY
F Grases, A Costa-Bauzá
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引用次数: 0

摘要

活性氧可以促进肾结石的形成,这一过程需要与肾乳头相关的细胞参与。在这里,我们提出了不同类型的肾乳头状结石的特征和可能的途径负责其形成的修订解释。我们检查了一个包含15000个结石的生物库中的肾结石,并确定了五种不同类型的乳头状结石。I型结石是一水草酸钙(COM)结石,明显有兰德尔斑块,但在石组织连接处没有肾小管。II型结石是COM型结石,在石组织连接处周围有兰德尔氏斑块和钙化的肾小管。III型结石是草酸钙二水合物(COD)结石,具有石组织连接处和钙化肾小管。IV型结石是COM型结石,含有尿酸和/或钠或钾酸盐的重要沉积物,与磷灰石一起出现在石组织连接处,也可能含有细菌印记。V型结石是小的COM型结石,在石组织交界处没有羟基磷灰石沉积。乳头状组织的氧化应激可产生异质核,促进磷酸钙和草酸钙的结晶,尿液成分决定了最终形成的乳头状结石的类型。积极的免疫反应可以通过消除组织内羟基磷灰石沉积或促进外尿上皮的再生来限制或阻止这些结石的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kidney stones and oxidative stress. Types of papillary renal calculi.

Reactive oxygen species can promote the formation of kidney stones, and this process requires the participation of cells associated with the renal papilla. Here, we present a revised interpretation of the characteristics of the different types of renal papillary stones and the possible pathways responsible for their formation. We examined kidney stones from a biobank that contains 15,000 stones and identified five different types of papillary stones. Type I stones are calcium oxalate monohydrate (COM) stones that clearly have Randall's plaque but have no renal tubules near the stone-tissue junction. Type II stones are COM stones that have Randall's plaque and calcified renal tubules around the stone-tissue junction. Type III stones are calcium oxalate dihydrate (COD) stones that have a stone-tissue junction and calcified renal tubules. Type IV stones are COM stones containing important deposits of uric acid and/or Na or K urates that occur around stone-tissue junction, together with apatite phosphate, and may also contain bacterial imprints. Type V stones are small COM calculi that have no hydroxyapatite deposits at the stone-tissue junction. Oxidative stress of papillary tissues can generate heterogeneous nucleants that promote the crystallization of calcium phosphate and calcium oxalate, and urine composition determines the type of papillary stone ultimately develops. An active immune response can limit or prevent the development of these stones by eliminating the intra-tissue hydroxyapatite deposits or promoting the regeneration of the outer uroepithelium.

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来源期刊
Urolithiasis
Urolithiasis UROLOGY & NEPHROLOGY-
CiteScore
4.50
自引率
6.50%
发文量
74
期刊介绍: Official Journal of the International Urolithiasis Society The journal aims to publish original articles in the fields of clinical and experimental investigation only within the sphere of urolithiasis and its related areas of research. The journal covers all aspects of urolithiasis research including the diagnosis, epidemiology, pathogenesis, genetics, clinical biochemistry, open and non-invasive surgical intervention, nephrological investigation, chemistry and prophylaxis of the disorder. The Editor welcomes contributions on topics of interest to urologists, nephrologists, radiologists, clinical biochemists, epidemiologists, nutritionists, basic scientists and nurses working in that field. Contributions may be submitted as full-length articles or as rapid communications in the form of Letters to the Editor. Articles should be original and should contain important new findings from carefully conducted studies designed to produce statistically significant data. Please note that we no longer publish articles classified as Case Reports. Editorials and review articles may be published by invitation from the Editorial Board. All submissions are peer-reviewed. Through an electronic system for the submission and review of manuscripts, the Editor and Associate Editors aim to make publication accessible as quickly as possible to a large number of readers throughout the world.
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