左旋多巴与营养支持：帕金森-高热综合征1例报告。

IF 2.2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition in Clinical Practice Pub Date : 2025-04-13 DOI:10.1002/ncp.11297

Ryan Burslem, Liz Ramos, Chou Chou, Carolina Szlufman, Jane Ziegler

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引用次数: 0

摘要

左旋多巴通过肠壁和血脑屏障的吸收受到氨基酸的竞争性抑制。左旋多巴急性停药增加帕金森-高热综合征的风险，这是一种以肌肉僵硬、精神状态改变、高热和自主神经不稳定为特征的危及生命的疾病。本报告讨论了帕金森病患者危重症谁发展帕金森-高热综合征，而接受肠内和肠外营养支持的情况下。当给服用左旋多巴的患者开营养支持处方时，临床医生应该意识到这种潜在的药物-营养相互作用。

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Levodopa and nutrition support: A case report of Parkinsonism-hyperpyrexia syndrome.

Levodopa is competitively inhibited by amino acids for absorption across the intestinal wall and blood-brain barrier. An acute withdrawal of levodopa increases the risk of Parkinsonism-hyperpyrexia syndrome, a life-threatening condition characterized by muscular rigidity, mental status changes, hyperthermia, and autonomic instability. This report discusses the case of a patient with Parkinson's disease who was critically ill who developed Parkinsonism-hyperpyrexia syndrome while receiving enteral and parenteral nutrition support. Clinicians should be aware of this potential drug-nutrient interaction when prescribing nutrition support to patients taking levodopa.

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来源期刊

Nutrition in Clinical Practice 医学-营养学

CiteScore

6.00

自引率

9.70%

发文量

128

审稿时长

3 months

期刊介绍： NCP is a peer-reviewed, interdisciplinary publication that publishes articles about the scientific basis and clinical application of nutrition and nutrition support. NCP contains comprehensive reviews, clinical research, case observations, and other types of papers written by experts in the field of nutrition and health care practitioners involved in the delivery of specialized nutrition support. This journal is a member of the Committee on Publication Ethics (COPE).