Bingxuan Weng, Jin Jin, Lixue Huang, Wenshu Jiao, Mengyuan Wang, Xinyue Zhang, Xunliang Tong, Yanming Li
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Patients aged over 65 years hospitalized for acute LRTIs were consecutively enrolled and underwent IC evaluations upon admission between April 15, 2021, and January 15, 2023. Outcomes included 6-month mortality and re-hospitalization. Latent class analysis identified patterns of IC deficits, and multivariable logistic regression models assessed associations between IC deficit domains/patterns and adverse outcomes.</p><p><strong>Results: </strong>A total of 1,001 older patients were included, with a mean age of 76 years (IQR: 69-84). Most of (839, 83.8%) the patients had at least one IC domain deficit. The 6-month re-hospitalization and mortality rates were 20.7% (190/933) and 7.7% (70/914). More domains of IC deficits, particularly in cognition (OR 1.873) and vitality (OR 1.737) deficits were associated with increased 6-month re-hospitalization rates. Three distinct IC deficit patterns were identified: relatively robust (73.5%), limited vitality and locomotion (18.6%), and impaired cognition, vision, and hearing group (7.9%). Compared to the relatively robust group, the limited vitality and locomotion group had a significantly higher risk of re-hospitalization (OR 2.025, 95% CI 1.388-2.932).</p><p><strong>Conclusion: </strong>IC deficits were prevalent and associated with increased re-hospitalization in older adults with LRTIs. Early detection and targeted interventions may reduce re-hospitalization rates and improve patient outcomes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"471-482"},"PeriodicalIF":3.5000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034263/pdf/","citationCount":"0","resultStr":"{\"title\":\"Intrinsic Capacity Deficits and 6-Month Outcomes in Older Adults with Acute LRTIs: A Multi-Center Study.\",\"authors\":\"Bingxuan Weng, Jin Jin, Lixue Huang, Wenshu Jiao, Mengyuan Wang, Xinyue Zhang, Xunliang Tong, Yanming Li\",\"doi\":\"10.2147/CIA.S501592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Intrinsic capacity (IC), representing an individual's physical and mental abilities, is associated with adverse outcomes. Acute lower respiratory tract infections (LRTIs) contribute to poor long-term prognosis, yet effective assessment and intervention strategies remain limited. Given the critical role of IC in the aging population, understanding its prevalence and impact in older adults with LRTIs is crucial for improving management strategies. This study aims to characterize the domains and patterns of IC deficits and assess their influence on 6-month mortality and re-hospitalization in this population.</p><p><strong>Methods: </strong>This was a multi-center prospective cohort study conducted in China. Patients aged over 65 years hospitalized for acute LRTIs were consecutively enrolled and underwent IC evaluations upon admission between April 15, 2021, and January 15, 2023. Outcomes included 6-month mortality and re-hospitalization. Latent class analysis identified patterns of IC deficits, and multivariable logistic regression models assessed associations between IC deficit domains/patterns and adverse outcomes.</p><p><strong>Results: </strong>A total of 1,001 older patients were included, with a mean age of 76 years (IQR: 69-84). Most of (839, 83.8%) the patients had at least one IC domain deficit. The 6-month re-hospitalization and mortality rates were 20.7% (190/933) and 7.7% (70/914). More domains of IC deficits, particularly in cognition (OR 1.873) and vitality (OR 1.737) deficits were associated with increased 6-month re-hospitalization rates. Three distinct IC deficit patterns were identified: relatively robust (73.5%), limited vitality and locomotion (18.6%), and impaired cognition, vision, and hearing group (7.9%). Compared to the relatively robust group, the limited vitality and locomotion group had a significantly higher risk of re-hospitalization (OR 2.025, 95% CI 1.388-2.932).</p><p><strong>Conclusion: </strong>IC deficits were prevalent and associated with increased re-hospitalization in older adults with LRTIs. Early detection and targeted interventions may reduce re-hospitalization rates and improve patient outcomes.</p>\",\"PeriodicalId\":48841,\"journal\":{\"name\":\"Clinical Interventions in Aging\",\"volume\":\"20 \",\"pages\":\"471-482\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034263/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Interventions in Aging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CIA.S501592\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Interventions in Aging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CIA.S501592","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：内在能力（IC），代表一个人的身体和心理能力，与不良后果有关。急性下呼吸道感染（LRTIs）导致较差的长期预后，但有效的评估和干预策略仍然有限。鉴于IC在老龄化人口中的关键作用，了解其在老年下呼吸道感染患者中的患病率和影响对于改善管理策略至关重要。本研究旨在描述IC缺损的领域和模式，并评估其对该人群6个月死亡率和再住院的影响。方法：这是一项在中国进行的多中心前瞻性队列研究。在2021年4月15日至2023年1月15日期间，连续入组65岁以上急性下呼吸道感染住院患者，并在入院时进行IC评估。结果包括6个月死亡率和再次住院。潜在分类分析确定了IC缺陷模式，多变量逻辑回归模型评估了IC缺陷领域/模式与不良结果之间的关联。结果：共纳入1001例老年患者，平均年龄76岁（IQR: 69-84）。大多数（839,83.8%）患者存在至少一个IC结构域缺陷。6个月再住院率和死亡率分别为20.7%（190/933）和7.7%（70/914）。更多领域的IC缺陷，特别是认知（OR 1.873）和活力（OR 1.737）缺陷与6个月再住院率增加有关。确定了三种不同的IC缺陷模式：相对健壮（73.5%），活力和运动受限（18.6%），认知、视力和听力受损组（7.9%）。与相对健壮组相比，活力和运动受限组再次住院的风险明显更高（OR 2.025, 95% CI 1.388-2.932）。结论：IC缺陷在老年下呼吸道感染患者中普遍存在并与再次住院增加相关。早期发现和有针对性的干预可以降低再住院率并改善患者的预后。
Intrinsic Capacity Deficits and 6-Month Outcomes in Older Adults with Acute LRTIs: A Multi-Center Study.
Objective: Intrinsic capacity (IC), representing an individual's physical and mental abilities, is associated with adverse outcomes. Acute lower respiratory tract infections (LRTIs) contribute to poor long-term prognosis, yet effective assessment and intervention strategies remain limited. Given the critical role of IC in the aging population, understanding its prevalence and impact in older adults with LRTIs is crucial for improving management strategies. This study aims to characterize the domains and patterns of IC deficits and assess their influence on 6-month mortality and re-hospitalization in this population.
Methods: This was a multi-center prospective cohort study conducted in China. Patients aged over 65 years hospitalized for acute LRTIs were consecutively enrolled and underwent IC evaluations upon admission between April 15, 2021, and January 15, 2023. Outcomes included 6-month mortality and re-hospitalization. Latent class analysis identified patterns of IC deficits, and multivariable logistic regression models assessed associations between IC deficit domains/patterns and adverse outcomes.
Results: A total of 1,001 older patients were included, with a mean age of 76 years (IQR: 69-84). Most of (839, 83.8%) the patients had at least one IC domain deficit. The 6-month re-hospitalization and mortality rates were 20.7% (190/933) and 7.7% (70/914). More domains of IC deficits, particularly in cognition (OR 1.873) and vitality (OR 1.737) deficits were associated with increased 6-month re-hospitalization rates. Three distinct IC deficit patterns were identified: relatively robust (73.5%), limited vitality and locomotion (18.6%), and impaired cognition, vision, and hearing group (7.9%). Compared to the relatively robust group, the limited vitality and locomotion group had a significantly higher risk of re-hospitalization (OR 2.025, 95% CI 1.388-2.932).
Conclusion: IC deficits were prevalent and associated with increased re-hospitalization in older adults with LRTIs. Early detection and targeted interventions may reduce re-hospitalization rates and improve patient outcomes.
期刊介绍：
Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.
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