从炎症到不育：氧化应激和感染如何破坏男性生殖健康。

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-04-11 DOI:10.3390/metabo15040267

Anastasios Potiris, Efthalia Moustakli, Eleni Trismpioti, Eirini Drakaki, Despoina Mavrogianni, Alkis Matsas, Athanasios Zikopoulos, Antonios Sfakianakis, Ioannis Tsakiridis, Themistoklis Dagklis, Athanasios Zachariou, Panagiotis Christopoulos, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros

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引用次数: 0

摘要

背景/目的：炎症、感染和氧化应激（OS）都对男性不育症有影响，这是一个复杂的、多方面的疾病。OS影响运动和受精能力。它通过破坏精子DNA、氧化蛋白质和触发脂质过氧化来实现这一目标。这些影响是由于活性氧（ROS）和抗氧化防御之间的不平衡而发生的。方法：通过对近期文献的梳理，综述氧化应激和炎症对男性不育症的影响。结果：促炎因子如TNF-α、IL-6干扰精子发生，促进氧化损伤。此外，由大肠杆菌和沙眼衣原体等病原体引起的感染会改变生殖微环境，导致精子功能障碍和炎症。结论：由于这些因素之间复杂的相互作用，早期发现和有针对性的治疗是必不可少的。微生物调节技术、抗菌疗法、抗炎药物和抗氧化剂是有助于减少氧化损伤和提高男性生育能力的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health.

Background/objectives: Inflammation, infections, and oxidative stress (OS) all have an impact on male infertility, which is a complicated, multifaceted illness. OS affects motility and fertilization capability. It accomplishes this through damaging sperm DNA, oxidizing proteins, and triggering lipid peroxidation. These effects occur due to an imbalance between reactive oxygen species (ROS) and antioxidant defenses.

Methods: This review aims to evaluate the impact of oxidative stress and inflammation on male infertility by assessing recent literature.

Results: Pro-inflammatory cytokines, like TNF-α and IL-6, interfere with spermatogenesis and promote oxidative damage. Additionally, infections caused by pathogens like Escherichia coli and Chlamydia trachomatis alter the reproductive microenvironment, leading to sperm dysfunction and inflammation.

Conclusions: Early detection and targeted treatment are essential due to the intricate interactions among these elements. Microbiota-modulating techniques, antimicrobial therapies, anti-inflammatory drugs, and antioxidants are therapeutic approaches that may help reduce oxidative damage and enhance male fertility.

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.