Germán Alfonso Landeros-García, Severo Manuel Abraham-Mancilla, José Oscar Juárez-Sánchez, Omar Alfredo Jiménez-García, Martha Alicia Hernández-González
{"title":"[血清维生素D与急性肾移植功能障碍的关系]。","authors":"Germán Alfonso Landeros-García, Severo Manuel Abraham-Mancilla, José Oscar Juárez-Sánchez, Omar Alfredo Jiménez-García, Martha Alicia Hernández-González","doi":"10.5281/zenodo.15178453","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a clinical entity characterized by definitive or non-reversible deterioration of the kidney's architecture and/or its functional status. Renal transplantation is the treatment of choice for CKD. New pharmacological therapies have been investigated with the aim of reducing the risk of renal graft rejection; an example of this is vitamin D. However, international evidence presents mixed results.</p><p><strong>Objective: </strong>To evaluate the relationship between serum vitamin D levels and the prevalence of acute renal graft dysfunction in renal transplant patients.</p><p><strong>Material and methods: </strong>A prospective, observational and comparative study was carried out with a population of patients who underwent renal transplantation. The patients were classified into 2 groups: group 1: patients with acute graft dysfunction, and group 2, those without acute graft dysfunction.</p><p><strong>Results: </strong>A statistically significant relationship was found between acute renal graft dysfunction and serum vitamin D levels (p = 0.003). All other characteristics did not show a statistically significant relationship with acute renal graft dysfunction.</p><p><strong>Conclusions: </strong>Low 25-hydroxyvitamin D levels showed a statistically significant association with acute renal graft dysfunction.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 3","pages":"e6448"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122061/pdf/","citationCount":"0","resultStr":"{\"title\":\"[Association of serum vitamin D and acute renal graft dysfunction].\",\"authors\":\"Germán Alfonso Landeros-García, Severo Manuel Abraham-Mancilla, José Oscar Juárez-Sánchez, Omar Alfredo Jiménez-García, Martha Alicia Hernández-González\",\"doi\":\"10.5281/zenodo.15178453\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a clinical entity characterized by definitive or non-reversible deterioration of the kidney's architecture and/or its functional status. Renal transplantation is the treatment of choice for CKD. New pharmacological therapies have been investigated with the aim of reducing the risk of renal graft rejection; an example of this is vitamin D. However, international evidence presents mixed results.</p><p><strong>Objective: </strong>To evaluate the relationship between serum vitamin D levels and the prevalence of acute renal graft dysfunction in renal transplant patients.</p><p><strong>Material and methods: </strong>A prospective, observational and comparative study was carried out with a population of patients who underwent renal transplantation. The patients were classified into 2 groups: group 1: patients with acute graft dysfunction, and group 2, those without acute graft dysfunction.</p><p><strong>Results: </strong>A statistically significant relationship was found between acute renal graft dysfunction and serum vitamin D levels (p = 0.003). All other characteristics did not show a statistically significant relationship with acute renal graft dysfunction.</p><p><strong>Conclusions: </strong>Low 25-hydroxyvitamin D levels showed a statistically significant association with acute renal graft dysfunction.</p>\",\"PeriodicalId\":94200,\"journal\":{\"name\":\"Revista medica del Instituto Mexicano del Seguro Social\",\"volume\":\"63 3\",\"pages\":\"e6448\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122061/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista medica del Instituto Mexicano del Seguro Social\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5281/zenodo.15178453\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista medica del Instituto Mexicano del Seguro Social","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5281/zenodo.15178453","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Association of serum vitamin D and acute renal graft dysfunction].
Background: Chronic kidney disease (CKD) is a clinical entity characterized by definitive or non-reversible deterioration of the kidney's architecture and/or its functional status. Renal transplantation is the treatment of choice for CKD. New pharmacological therapies have been investigated with the aim of reducing the risk of renal graft rejection; an example of this is vitamin D. However, international evidence presents mixed results.
Objective: To evaluate the relationship between serum vitamin D levels and the prevalence of acute renal graft dysfunction in renal transplant patients.
Material and methods: A prospective, observational and comparative study was carried out with a population of patients who underwent renal transplantation. The patients were classified into 2 groups: group 1: patients with acute graft dysfunction, and group 2, those without acute graft dysfunction.
Results: A statistically significant relationship was found between acute renal graft dysfunction and serum vitamin D levels (p = 0.003). All other characteristics did not show a statistically significant relationship with acute renal graft dysfunction.
Conclusions: Low 25-hydroxyvitamin D levels showed a statistically significant association with acute renal graft dysfunction.