G Yang, A He, Y Li, S Lü, M Chen, L Tian, Q Liu, L Duan, Y Lu, J Yang, S Li, X Zhou, J Wang, S Zhang
{"title":"[1990年至2021年内脏利什曼病全球负担趋势及2035年预测]。","authors":"G Yang, A He, Y Li, S Lü, M Chen, L Tian, Q Liu, L Duan, Y Lu, J Yang, S Li, X Zhou, J Wang, S Zhang","doi":"10.16250/j.32.1915.2024251","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the global burden of visceral leishmaniasis (VL) from 1990 to 2021 and predict the trends in the burden of VL from 2022 to 2035, so as to provide insights into global VL prevention and control.</p><p><strong>Methods: </strong>The global age-standardized incidence, prevalence, mortality and disability-adjusted life years (DALYs) rates of VL and their 95% uncertainty intervals (<i>UI</i>) were captured from the Global Burden of Disease Study 2021 (GBD 2021) data resources. The trends in the global burden of VL were evaluated with average annual percent change (AAPC) and 95% confidence interval (<i>CI</i>) from 1990 to 2021, and gender-, age-, country-, geographical area- and socio-demographic index (SDI)-stratified burdens of VL were analyzed. The trends in the global burden of VL were projected with a Bayesian age-period-cohort (BAPC) model from 2022 to 2035, and the associations of age-standardized incidence, prevalence, mortality, and DALYs rates of VL with SDI levels were examined with a smoothing spline model.</p><p><strong>Results: </strong>The global age-standardized incidence [AAPC = -0.25%, 95% <i>CI</i>: (-0.25%, -0.24%)], prevalence [AAPC = -0.06%, 95% <i>CI</i>: (-0.06%, -0.06%)], mortality [AAPC = -0.25%, 95% <i>CI</i>: (-0.25%, -0.24%)] and DALYs rates of VL [AAPC = -2.38%, 95% <i>CI</i>: (-2.44%, -2.33%)] all appeared a tendency towards a decline from 1990 to 2021, and the highest age-standardized incidence [2.55/10<sup>5</sup>, 95% <i>UI</i>: (1.49/10<sup>5</sup>, 4.07/10<sup>5</sup>)], prevalence [0.64/10<sup>5</sup>, 95% <i>UI</i>: (0.37/10<sup>5</sup>, 1.02/10<sup>5</sup>)], mortality [0.51/10<sup>5</sup>, 95% <i>UI</i>: (0, 1.80/10<sup>5</sup>)] and DALYs rates of VL [33.81/10<sup>5</sup>, 95% <i>UI</i>: (0.06/10<sup>5</sup>, 124.09/10<sup>5</sup>)] were seen in tropical Latin America in 2021. The global age-standardized incidence and prevalence of VL were both higher among men [0.57/10<sup>5</sup>, 95% <i>UI</i>: (0.45/10<sup>5</sup>, 0.72/10<sup>5</sup>); 0.14/10<sup>5</sup>, 95% <i>UI</i>: (0.11/10<sup>5</sup>, 0.18/10<sup>5</sup>)] than among women [0.27/10<sup>5</sup>, 95% <i>UI</i>: (0.21/10<sup>5</sup>, 0.33/10<sup>5</sup>); 0.06/10<sup>5</sup>, 95% <i>UI</i>: (0.05/10<sup>5</sup>, 0.08/10<sup>5</sup>)], and the highest mortality of VL was found among children under 5 years of age [0.24/10<sup>5</sup>, 95% <i>UI</i>: (0.08/10<sup>5</sup>, 0.66/10<sup>5</sup>)]. The age-standardized incidence (<i>r</i> = -0.483, <i>P</i> < 0.001), prevalence (<i>r</i> = -0.483, <i>P</i> < 0.001), mortality (<i>r</i> = -0.511, <i>P</i> < 0.001) and DALYs rates of VL (<i>r</i> = -0.514, <i>P</i> < 0.001) correlated negatively with SDI levels from 1990 to 2021. In addition, the global burden of VL was projected with the BAPC model to appear a tendency towards a decline from 2022 to 2035, and the age-standardized incidence, prevalence, mortality and DALYs rates were projected to be reduced to 0.11/10<sup>5</sup>, 0.03/10<sup>5</sup>, 0.02/10<sup>5</sup> and 1.44/10<sup>5</sup> in 2035, respectively.</p><p><strong>Conclusions: </strong>Although the global burden of VL appeared an overall tendency towards a decline from 1990 to 2021, the burden of VL showed a tendency towards a rise in Central Asia and western sub-Saharan African areas. The age-standardized incidence and prevalence rates of VL were relatively higher among men, and the age-standardized mortality of VL was relatively higher among children under 5 years of age. The global burden of VL was projected to continue to decline from 2022 to 2035.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 1","pages":"35-43"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Trends in global burden due to visceral leishmaniasis from 1990 to 2021 and projections up to 2035].\",\"authors\":\"G Yang, A He, Y Li, S Lü, M Chen, L Tian, Q Liu, L Duan, Y Lu, J Yang, S Li, X Zhou, J Wang, S Zhang\",\"doi\":\"10.16250/j.32.1915.2024251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the global burden of visceral leishmaniasis (VL) from 1990 to 2021 and predict the trends in the burden of VL from 2022 to 2035, so as to provide insights into global VL prevention and control.</p><p><strong>Methods: </strong>The global age-standardized incidence, prevalence, mortality and disability-adjusted life years (DALYs) rates of VL and their 95% uncertainty intervals (<i>UI</i>) were captured from the Global Burden of Disease Study 2021 (GBD 2021) data resources. The trends in the global burden of VL were evaluated with average annual percent change (AAPC) and 95% confidence interval (<i>CI</i>) from 1990 to 2021, and gender-, age-, country-, geographical area- and socio-demographic index (SDI)-stratified burdens of VL were analyzed. The trends in the global burden of VL were projected with a Bayesian age-period-cohort (BAPC) model from 2022 to 2035, and the associations of age-standardized incidence, prevalence, mortality, and DALYs rates of VL with SDI levels were examined with a smoothing spline model.</p><p><strong>Results: </strong>The global age-standardized incidence [AAPC = -0.25%, 95% <i>CI</i>: (-0.25%, -0.24%)], prevalence [AAPC = -0.06%, 95% <i>CI</i>: (-0.06%, -0.06%)], mortality [AAPC = -0.25%, 95% <i>CI</i>: (-0.25%, -0.24%)] and DALYs rates of VL [AAPC = -2.38%, 95% <i>CI</i>: (-2.44%, -2.33%)] all appeared a tendency towards a decline from 1990 to 2021, and the highest age-standardized incidence [2.55/10<sup>5</sup>, 95% <i>UI</i>: (1.49/10<sup>5</sup>, 4.07/10<sup>5</sup>)], prevalence [0.64/10<sup>5</sup>, 95% <i>UI</i>: (0.37/10<sup>5</sup>, 1.02/10<sup>5</sup>)], mortality [0.51/10<sup>5</sup>, 95% <i>UI</i>: (0, 1.80/10<sup>5</sup>)] and DALYs rates of VL [33.81/10<sup>5</sup>, 95% <i>UI</i>: (0.06/10<sup>5</sup>, 124.09/10<sup>5</sup>)] were seen in tropical Latin America in 2021. The global age-standardized incidence and prevalence of VL were both higher among men [0.57/10<sup>5</sup>, 95% <i>UI</i>: (0.45/10<sup>5</sup>, 0.72/10<sup>5</sup>); 0.14/10<sup>5</sup>, 95% <i>UI</i>: (0.11/10<sup>5</sup>, 0.18/10<sup>5</sup>)] than among women [0.27/10<sup>5</sup>, 95% <i>UI</i>: (0.21/10<sup>5</sup>, 0.33/10<sup>5</sup>); 0.06/10<sup>5</sup>, 95% <i>UI</i>: (0.05/10<sup>5</sup>, 0.08/10<sup>5</sup>)], and the highest mortality of VL was found among children under 5 years of age [0.24/10<sup>5</sup>, 95% <i>UI</i>: (0.08/10<sup>5</sup>, 0.66/10<sup>5</sup>)]. The age-standardized incidence (<i>r</i> = -0.483, <i>P</i> < 0.001), prevalence (<i>r</i> = -0.483, <i>P</i> < 0.001), mortality (<i>r</i> = -0.511, <i>P</i> < 0.001) and DALYs rates of VL (<i>r</i> = -0.514, <i>P</i> < 0.001) correlated negatively with SDI levels from 1990 to 2021. In addition, the global burden of VL was projected with the BAPC model to appear a tendency towards a decline from 2022 to 2035, and the age-standardized incidence, prevalence, mortality and DALYs rates were projected to be reduced to 0.11/10<sup>5</sup>, 0.03/10<sup>5</sup>, 0.02/10<sup>5</sup> and 1.44/10<sup>5</sup> in 2035, respectively.</p><p><strong>Conclusions: </strong>Although the global burden of VL appeared an overall tendency towards a decline from 1990 to 2021, the burden of VL showed a tendency towards a rise in Central Asia and western sub-Saharan African areas. The age-standardized incidence and prevalence rates of VL were relatively higher among men, and the age-standardized mortality of VL was relatively higher among children under 5 years of age. The global burden of VL was projected to continue to decline from 2022 to 2035.</p>\",\"PeriodicalId\":38874,\"journal\":{\"name\":\"中国血吸虫病防治杂志\",\"volume\":\"37 1\",\"pages\":\"35-43\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国血吸虫病防治杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.16250/j.32.1915.2024251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国血吸虫病防治杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.16250/j.32.1915.2024251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
[Trends in global burden due to visceral leishmaniasis from 1990 to 2021 and projections up to 2035].
Objective: To investigate the global burden of visceral leishmaniasis (VL) from 1990 to 2021 and predict the trends in the burden of VL from 2022 to 2035, so as to provide insights into global VL prevention and control.
Methods: The global age-standardized incidence, prevalence, mortality and disability-adjusted life years (DALYs) rates of VL and their 95% uncertainty intervals (UI) were captured from the Global Burden of Disease Study 2021 (GBD 2021) data resources. The trends in the global burden of VL were evaluated with average annual percent change (AAPC) and 95% confidence interval (CI) from 1990 to 2021, and gender-, age-, country-, geographical area- and socio-demographic index (SDI)-stratified burdens of VL were analyzed. The trends in the global burden of VL were projected with a Bayesian age-period-cohort (BAPC) model from 2022 to 2035, and the associations of age-standardized incidence, prevalence, mortality, and DALYs rates of VL with SDI levels were examined with a smoothing spline model.
Results: The global age-standardized incidence [AAPC = -0.25%, 95% CI: (-0.25%, -0.24%)], prevalence [AAPC = -0.06%, 95% CI: (-0.06%, -0.06%)], mortality [AAPC = -0.25%, 95% CI: (-0.25%, -0.24%)] and DALYs rates of VL [AAPC = -2.38%, 95% CI: (-2.44%, -2.33%)] all appeared a tendency towards a decline from 1990 to 2021, and the highest age-standardized incidence [2.55/105, 95% UI: (1.49/105, 4.07/105)], prevalence [0.64/105, 95% UI: (0.37/105, 1.02/105)], mortality [0.51/105, 95% UI: (0, 1.80/105)] and DALYs rates of VL [33.81/105, 95% UI: (0.06/105, 124.09/105)] were seen in tropical Latin America in 2021. The global age-standardized incidence and prevalence of VL were both higher among men [0.57/105, 95% UI: (0.45/105, 0.72/105); 0.14/105, 95% UI: (0.11/105, 0.18/105)] than among women [0.27/105, 95% UI: (0.21/105, 0.33/105); 0.06/105, 95% UI: (0.05/105, 0.08/105)], and the highest mortality of VL was found among children under 5 years of age [0.24/105, 95% UI: (0.08/105, 0.66/105)]. The age-standardized incidence (r = -0.483, P < 0.001), prevalence (r = -0.483, P < 0.001), mortality (r = -0.511, P < 0.001) and DALYs rates of VL (r = -0.514, P < 0.001) correlated negatively with SDI levels from 1990 to 2021. In addition, the global burden of VL was projected with the BAPC model to appear a tendency towards a decline from 2022 to 2035, and the age-standardized incidence, prevalence, mortality and DALYs rates were projected to be reduced to 0.11/105, 0.03/105, 0.02/105 and 1.44/105 in 2035, respectively.
Conclusions: Although the global burden of VL appeared an overall tendency towards a decline from 1990 to 2021, the burden of VL showed a tendency towards a rise in Central Asia and western sub-Saharan African areas. The age-standardized incidence and prevalence rates of VL were relatively higher among men, and the age-standardized mortality of VL was relatively higher among children under 5 years of age. The global burden of VL was projected to continue to decline from 2022 to 2035.
期刊介绍：
Chinese Journal of Schistosomiasis Control (ISSN: 1005-6661, CN: 32-1374/R), founded in 1989, is a technical and scientific journal under the supervision of Jiangsu Provincial Health Commission and organised by Jiangsu Institute of Schistosomiasis Control. It is a scientific and technical journal under the supervision of Jiangsu Provincial Health Commission and sponsored by Jiangsu Institute of Schistosomiasis Prevention and Control. The journal carries out the policy of prevention-oriented, control-oriented, nationwide and grassroots, adheres to the tenet of scientific research service for the prevention and treatment of schistosomiasis and other parasitic diseases, and mainly publishes academic papers reflecting the latest achievements and dynamics of prevention and treatment of schistosomiasis and other parasitic diseases, scientific research and management, etc. The main columns are Guest Contributions, Experts‘ Commentary, Experts’ Perspectives, Experts' Forums, Theses, Prevention and Treatment Research, Experimental Research, The main columns include Guest Contributions, Expert Commentaries, Expert Perspectives, Expert Forums, Treatises, Prevention and Control Studies, Experimental Studies, Clinical Studies, Prevention and Control Experiences, Prevention and Control Management, Reviews, Case Reports, and Information, etc. The journal is a useful reference material for the professional and technical personnel of schistosomiasis and parasitic disease prevention and control research, management workers, and teachers and students of medical schools.
The journal is now included in important domestic databases, such as Chinese Core List (8th edition), China Science Citation Database (Core Edition), China Science and Technology Core Journals (Statistical Source Journals), and is also included in MEDLINE/PubMed, Scopus, EBSCO, Chemical Abstract, Embase, Zoological Record, JSTChina, Ulrichsweb, Western Pacific Region Index Medicus, CABI and other international authoritative databases.
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